Amphiphilic core-shell nanoparticles: Synthesis, biophysical properties, and applications

Panday, Raju; Poudel, Abishek Jung; Li, Xiaohong; Adhikari, Manjila; Ullah, Muhammad Wajid; Yang, Guang

doi:10.1016/j.colsurfb.2018.08.019

Cited by 39 publications

(26 citation statements)

References 127 publications

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“…The core-shell nanocarriers based on amphiphilic copolymers have attracted great attention as a potential agents for cancer chemotherapy since the hydrophilic shell can ensure prolonged circulation of the carrier in blood, whereas the hydrophobic core can enhance drug loading efficiency [103,104]. Core-shell NPs from aliphatic polyesters are extensively used as promising materials for drug and gene delivery due to its useful properties, biocompatibility and excellent degradability [105,106].…”

Section: Polymeric Drug Delivery Systems From Cyclodextrin and Poly(εmentioning

confidence: 99%

Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

et al. 2020

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Cyclodextrins (CD) are a group of cyclic oligosaccharides with a cavity/specific structure that enables to form inclusion complexes (IC) with a variety of molecules through non-covalent host-guest interactions. By an elegant combination of CD with biocompatible, synthetic and natural polymers, different types of universal drug delivery systems with dynamic/reversible properties have been generated. This review presents the design of nano- and micro-carriers, hydrogels, and fibres based on the polymer/CD supramolecular systems highlighting their possible biomedical applications. Application of the most prominent hydrophobic aliphatic polyesters that exhibit biodegradability, represented by polylactide and polycaprolactone, is described first. Subsequently, particular attention is focused on materials obtained from hydrophilic polyethylene oxide. Moreover, examples are also presented for grafting of CD on polysaccharides. In summary, we show the application of host-guest interactions in multi-component functional biomaterials for controlled drug delivery.

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Section: Polymeric Drug Delivery Systems From Cyclodextrin and Poly(εmentioning

confidence: 99%

Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

et al. 2020

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“…Soft nano-particles can be further functionalised by using core-shell structure and are of great interest nowadays due to its use in drug delivery, bioseparation etc. [55,56].…”

Section: Experimental Studies Of Nano-particle Interactionsmentioning

confidence: 99%

Interactions between nanoparticles in nanosuspension

Kovalchuk

Johnson

Соболев

et al. 2019

Advances in Colloid and Interface Science

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Where a licence is displayed above, please note the terms and conditions of the licence govern your use of this document. When citing, please reference the published version. Take down policy While the University of Birmingham exercises care and attention in making items available there are rare occasions when an item has been uploaded in error or has been deemed to be commercially or otherwise sensitive.

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“…The morphologies of hybrid nanogels may be multiple, according to the type of involved particles and to the assembly technique [23,24]. Frequently, the nanoparticles represent the core of the hybrid, surrounded by a polymer shell [25,26,27] or homogeneously embedded in the polymer network [28,29]; in other cases, instead, the polymeric structures are themselves assembled in core-layer-shell geometries [30]. The sizes may vary according to the nanohybrid type and to the dimensions of the involved particles, however, as described below, the typical overall range is between 50 and about 400 nm.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Nanogels: Stealth and Biocompatible Structures for Drug Delivery Applications

2019

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Considering nanogels, we have focused our attention on hybrid nanosystems for drug delivery and biomedical purposes. The distinctive strength of these structures is the capability to join the properties of nanosystems with the polymeric structures, where versatility is strongly demanded for biomedical applications. Alongside with the therapeutic effect, a non-secondary requirement of the nanosystem is indeed its biocompatibility. The importance to fulfill this aim is not only driven by the priority to reduce, as much as possible, the inflammatory or the immune response of the organism, but also by the need to improve circulation lifetime, biodistribution, and bioavailability of the carried drugs. In this framework, we have therefore gathered the hybrid nanogels specifically designed to increase their biocompatibility, evade the recognition by the immune system, and overcome the self-defense mechanisms present in the bloodstream of the host organism. The works have been essentially organized according to the hybrid morphologies and to the strategies adopted to fulfill these aims: Nanogels combined with nanoparticles or with liposomes, and involving polyethylene glycol chains or zwitterionic polymers.

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Amphiphilic core-shell nanoparticles: Synthesis, biophysical properties, and applications

Cited by 39 publications

References 127 publications

Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

Interactions between nanoparticles in nanosuspension

Hybrid Nanogels: Stealth and Biocompatible Structures for Drug Delivery Applications

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