Amphiphilic copolymers with pendent carboxyl groups for high-efficiency loading and controlled release of doxorubicin

Li, Youmei; Jiang, Tao; Lv, Yin; Wu, Yan; He, Feng; Zhuo, Ren‐Xi

doi:10.1016/j.colsurfb.2015.04.066

Cited by 28 publications

(22 citation statements)

References 40 publications

(44 reference statements)

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“…As an effective strategy for clinical tumor treatment, chemotherapy plays an important role in tumor suppression and elimination . Thus, the development of suitable biodegradable drug‐delivery systems for the controlled in vitro release of mainly insoluble anticancer drugs such as DOX has attracted increasing attention …”

Section: Resultsmentioning

confidence: 99%

“…After a prolonged incubation time DOX fully co‐localized with the nuclei of the HeLa cells (Figure b), which suggested successful internalization of the micelles and release of DOX within the cells. To exhibit anticancer activity, DOX must intercalate into DNA, and subsequently inhibit topoisomerase II to prevent replication within the tumor cells and induce cell death . Hence, the observed migration of DOX from the BAB 3 micelles into the nucleus is critical for its function as a therapeutic agent (Figure b).…”

Section: Resultsmentioning

confidence: 99%

“…[31] Thus, the development of suitable biodegradable drug-delivery systemsf or the controlled in vitro releaseo f mainly insoluble anticancer drugs such as DOX has attracted increasing attention. [32] Consequently,w ei nvestigated whether DOX-loaded BAB 3 micelles could be efficiently internalized into HeLa cells. If DOX is released, the viability of the cancerc ell will be decreased.…”

Section: Intracellular Dox Release and Antitumor Activitymentioning

confidence: 99%

See 2 more Smart Citations

Next Generation Multiresponsive Nanocarriers for Targeted Drug Delivery to Cancer Cells

Altenbuchner

Werz

Schöppner

et al. 2016

Chemistry A European J

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C-H bond activation of 2-methoxyethylamino-bis(phenolate)-yttrium catalysts allowed the synthesis of BAB block copolymers comprised of 2-vinylpyridine (2VP; monomer A) and diethylvinylphosphonate (DEVP; monomer B) as the A and B blocks, respectively, by rare-earth-metal-mediated group-transfer polymerization (REM-GTP). The inherent multi-stimuli-responsive character and drug-loading and -release capabilities were observed to be dependent on the chain length and monomer ratios. Cytotoxicity assays revealed the biocompatibility and nontoxic nature of the obtained micelles toward ovarian cancer (HeLa) cells. The BAB block copolymers effectively encapsulated, transported, and released doxorubicin (DOX) within HeLa cells. REM-GTP enables access to previously unattainable vinylphosphonate copolymer structures, and thereby unlocks their full potential as nanocarriers for stimuli-responsive drug delivery in HeLa cells. The self-evident consequence is the application of these new micelles as potent drug-delivery vehicles with reduced side effects in future cancer therapies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Intracellular Dox Release and Antitumor Activitymentioning

confidence: 99%

See 1 more Smart Citation

Next Generation Multiresponsive Nanocarriers for Targeted Drug Delivery to Cancer Cells

Altenbuchner

Werz

Schöppner

et al. 2016

Chemistry A European J

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“…Ring‐opening polymerization of AB 2 ‐type monomer yielded hyperbranched polycarbonates, as shown in Scheme . Allyl‐containing carbonate monomer could be employed to generate polycarbonates for post‐polymerization modification such as the transformation of pendent carboxyl groups using thioglycolic acid or hydrophobic chains using 1‐dodecanethiol by thiol‐ene reaction.…”

Section: Click Chemistry In the Synthesis Of Functional Aliphatic Polmentioning

confidence: 99%

Click Chemistry in Functional Aliphatic Polycarbonates

Dai

Zhang

Xia

2017

Macromol. Rapid Commun.

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Click chemistry, one of the most important methods in conjugation, plays an extremely significant role in the synthesis of functional aliphatic polycarbonates, which are a group of biodegradable polymers containing carbonate bonds in their main chains. To date, more than 75 articles have been reported on the topic of click chemistry in functional aliphatic polycarbonates. However, these efforts have not yet been highlighted. Six categories of click reactions (alkyne-azide reaction, thiol-ene reaction, Michael addition, epoxy-amine/thiol reaction, Diels-Alder reaction, and imine formation) that have been afforded for further post-polymerization modification of polycarbonates are reviewed. Through this review, a comprehensive understanding of functional aliphatic polycarbonates aims to afford insight on the design of polycarbonates for further post-polymerization modification via click chemistry and the expectation of the practical application.

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“…Among them, systematically studied bifunctional (EO) x -(PO) y -(EO) x block copolymers, Pluronics®, have been shown to modulate functional activity of cellular membranes and increase their permeability to different drugs [14]. Other amphiphilic polymers, including non-ionic PEG-PLA [15], charged quaternised poly(propylene imine) dendrimer [16] and thioglycolic acidmodified methoxy PEG-b-poly(5-allyloxy-1,3-dioxan-2-one) [17] were recently proposed as micellar carriers for anticancer and anti-inflammatory compounds.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive topical drug delivery to spinal cord with carboxyl-modified trifunctional copolymer of ethylene oxide and propylene oxide

Kamalov

Lavrov

Yergeshov

et al. 2016

Colloids and Surfaces B: Biointerfaces

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In this study the effect of oxidative modification on micellar and drug deliveryproperties of copolymers of ethylene oxide (EO) and propylene oxide (PO) wasinvestigated. Carboxylated trifunctional copolymers were synthesized in the reaction withchromium oxide (VI). We found that carboxylation significantly improved the uniformityand stability of polymeric micelles by inhibiting the microphase transition. Thecytotoxicity of copolymers was studied in relation to their aggregative state on two celltypes (cancer line vs. primary fibroblasts). The accumulation of rhodamine 123 inneuroblastoma SH-SY5Y cells was dramatically increased in the presence of the oxidizedblock copolymer with the number of PO and EO units of 83.5 and 24.2, respectively. Thecopolymer was also tested as an enhancer for topical drug delivery to the spinal cordwhen applied subdurally. The oxidized copolymer facilitated the penetration ofrhodamine 123 across spinal cord tissues and increased its intraspinal accumulation.These results show the potential of using oxidized EO/PO based polymers for noninvasivedelivery of protective drugs after spinal cord injury

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Amphiphilic copolymers with pendent carboxyl groups for high-efficiency loading and controlled release of doxorubicin

Cited by 28 publications

References 40 publications

Next Generation Multiresponsive Nanocarriers for Targeted Drug Delivery to Cancer Cells

Next Generation Multiresponsive Nanocarriers for Targeted Drug Delivery to Cancer Cells

Click Chemistry in Functional Aliphatic Polycarbonates

Non-invasive topical drug delivery to spinal cord with carboxyl-modified trifunctional copolymer of ethylene oxide and propylene oxide

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