Amphiphilic block copolymers significantly influence functions of bacteriorhodopsin in water

Ma, Da; Wang, Yazhuo; Jia, Wang; Zhao, Yingchun; Ming, Ming; Ding, Jiandong

doi:10.1039/c0sm00344a

Cited by 11 publications

(4 citation statements)

References 78 publications

(117 reference statements)

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“…The study of vesicles with definite morphologies still remains a great challenge to supramolecular chemistry. Block‐copolymer–micelle (BCM) complexes have attracted much interest for over the last two decades due to their wide range of technical applications in many areas, such as paints, coating fluids, inks, drug delivery systems and pharmaceutical compounds (11–16). Fluorescence is a very useful tool, among many experimental techniques to study the BCM interactions, for elucidation of detailed structural aspects of the process of BCM interaction (17).…”

Section: Introductionmentioning

confidence: 99%

Photophysical Characterization of 1,8 Naphthalimide in Micelle‐diblock Copolymer Nano‐composite: A Case of Morphological Transformation and Vesicle Formation

Manna¹,

Chakravorti²

2011

Photochem & Photobiology

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This paper reports a morphological transition of the spherical colloidal structures of the sodium dodecyl sulfate-polyethylene-bpolyethylene glycol (SDS-PE-b-PEG) complex and anionic micelle (SDS) to ''rod-shaped'' colloidal structures induced by a charge transfer dye, 1,8-naphthalimide (NAPMD) (forms anions in aqueous solution by intermolecular charge transfer). The distinct steady-state results of NAPMD in the above two media point toward the formation of a new microenvironment. SDS and SDS-PE-b-PEG form unilamellar (ULV) and multilamellar vesicles (MLV), respectively, along with the rod-shaped colloidal structures as observed from transmission electron microscopy (TEM) images. This dye causes a variation in the hydrophilic ⁄ hydrophobic ratio and forms a hydrogen bond with the copolymer in the SDS-PE-b-PEG complex and subjected to electrostatic interaction with the SDS micelle in aqueous solution, which causes this morphological transformation. These vesicles show complete encapsulation of a hydrophobic dye in its interior as evident from the TEM images. ULV get ruptured at low pH, pointing toward their lower stability over MLV at low pH value. The formation of these vesicles with complete idea of its mechanism, encapsulation of bioactive molecules and its rupture at lower pH raise hope as a potential nanoscale vehicle for biologically relevant compounds and their release at low pH medium.

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Section: Introductionmentioning

confidence: 99%

Photophysical Characterization of 1,8 Naphthalimide in Micelle‐diblock Copolymer Nano‐composite: A Case of Morphological Transformation and Vesicle Formation

Manna¹,

Chakravorti²

2011

Photochem & Photobiology

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“…Subsequently, the ability to form three‐dimensional patterns based on block copolymers was demonstrated using three different methods: processing of the block copolymer and a protein–polymer conjugate in an organic solvent to form thin films,56 self‐assembly of membrane proteins within Pluronic block copolymer layers57 and micelles,58 and the use of ionic interactions to drive protein segregation into solid block copolymers using all aqueous processing (Figure 1). 59 Large protein particles, such as ferritin, can also be used in templated self‐assembly when PEGylated to drive segregation into a specific block copolymer domain 39, 60.…”

Section: Self‐assembled Globular Protein Nanostructuresmentioning

confidence: 99%

Self‐Assembly of Globular‐Protein‐Containing Block Copolymers

Olsen¹

2013

Macro Chemistry & Physics

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Self-assembly has emerged as a powerful approach to control nanostructure in materials containing globular proteins, both through templated self-assembly and direct self-assembly of globular protein-polymer conjugates or fusion proteins. The folded structures of globular proteins that are critical to their function introduce complex shapes and interactions into block copolymers that significantly alter the physics of self-assembly. This article discusses the different methods for controlling the nanostructure of globular proteins using block copolymers, highlighting efforts at understanding the physics of self-assembly in concentrated solution and solid-state bioconjugate copolymers.

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“…Due to the poor processibility of BR itself, one usually embeds BR into a polymeric matrix to obtain a functional composite "material" [5,[9][10][11][12][13][14][15][16][17]. While gelatin/BR films have been a typical kind of BR-containing materials with good mechanical properties and optical transparency [18][19][20], it is very difficult to introduce detergents or strong alkaline substances into the matrix due to the following reasons: if the films are exposed to those environments, the film integrity cannot be kept; or if those substances are added into a suspension of BR and polymer before film formation, the BR proteins are inclined to denature during dehydration to form a film.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a cross-linked gelatin/bacteriorhodopsin film and its photochromic properties

Wang

Jia

et al. 2011

Sci. China Chem.

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Amphiphilic block copolymers significantly influence functions of bacteriorhodopsin in water

Cited by 11 publications

References 78 publications

Photophysical Characterization of 1,8 Naphthalimide in Micelle‐diblock Copolymer Nano‐composite: A Case of Morphological Transformation and Vesicle Formation

Photophysical Characterization of 1,8 Naphthalimide in Micelle‐diblock Copolymer Nano‐composite: A Case of Morphological Transformation and Vesicle Formation

Self‐Assembly of Globular‐Protein‐Containing Block Copolymers

Preparation of a cross-linked gelatin/bacteriorhodopsin film and its photochromic properties

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