Amphiphilic Block Copolymer-Guided <i>in Situ</i> Fabrication of Stable and Highly Controlled Luminescent Copper Nanoassemblies

Zhou, Tingyao; Zhu, Jiayi; Gong, Lingshan; Nong, Liting; Liu, Jinbin

doi:10.1021/jacs.8b12026

Cited by 57 publications

(39 citation statements)

References 42 publications

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“…Open Access Article. 218 Moreover, the number of the encapsulated CuNCs inside the core can be controlled by adjusting the block segments of the template. The clusters are assembled into uniform structures and held together through the cross-linking of multidentate thiol ligand.…”

Section: Nanoscale Accepted Manuscriptmentioning

confidence: 99%

Copper nanoclusters: designed synthesis, structural diversity, and multiplatform applications

2021

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Section: Nanoscale Accepted Manuscriptmentioning

confidence: 99%

Copper nanoclusters: designed synthesis, structural diversity, and multiplatform applications

2021

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“…It is worth mentioning that this strategy gives us insight into designing high-efficiency luminescent CuNCs. It has been found that many CuNCs have unique AIEE properties (Li et al 2016a;Liu et al 2018b;Zhou et al 2019).…”

Section: Solvent Effectmentioning

confidence: 99%

Highly fluorescent copper nanoclusters for sensing and bioimaging

Ren

Bick

et al. 2020

Biosensors and Bioelectronics

147

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Metal nanoclusters (NCs), typically consisting of a few to tens of metal atoms, bridge the gap between organometallic compounds and crystalline metal nanoparticles. As their size approaches the Fermi wavelength of electrons, metal NCs exhibit discrete energy levels, which in turn results in the emergence of intriguing physical and chemical (or physicochemical) properties, especially strong fluorescence. In the past few decades, dramatic growth has been witnessed in the development of different types of noble metal NCs (mainly AuNCs and AgNCs). However, compared with noble metals, copper is a relatively earth-abundant and cost-effective metal. Theoretical and experimental studies have shown that copper NCs (CuNCs) possess unique catalytic and photoluminescent properties. In this context, CuNCs are emerging as a new class of nontoxic, economic, and effective phosphors and catalysts, drawing significant interest across the life and medical sciences. To highlight these achievements, this review begins by providing an overview of a multitude of factors that play central roles in the fluorescence of CuNCs. Additionally, a critical perspective of how the aggregation of CuNCs can efficiently improve the florescent stability, tunability, and intensity is also discussed. Following, we present representative applications of CuNCs in detection and bioimaging. Finally, we outline current challenges and our perspective on the development of CuNCs.When decreasing the size of nanoparticles so that it approaches the Fermi wavelength of an electron, novel optical, electrical and magnetic properties appear (Deng et al. 2018a; Li et al. 2016b;Moghadam and Rahaie 2019;Wang et al. 2018c). Commonly termed nanoclusters (NCs), these ultra-small nanoparticles, bridging the missing link between atoms and nanocrystals, have attracted considerable attention in both fundamental research and practical applications (Bagheri et al. 2017;Basu et al. 2019;Sun et al. 2019;Wang et al. 2016b). Benefiting from the great progress in nanosynthetic chemistry, high-quality Copper NCs (CuNCs) with tailored size and good stability can be easily obtained. CuNCs, therefore, constitute an active research direction due to their unique properties, such as high luminous efficiency, long fluorescence lifetime, good optical and chemical stability, and large stokes displacement, which distinguish them as a new type of fluorescent probe for optical sensing and bioimaging/labeling (Cao et al. 2014;Wang et al. 2017).In this review, we highlight recent developments of CuNCs, with a particular emphasis on the multiple factors affecting fluorescent properties of CuNCs, as well as the aggregation-induced emission enhancement (AIEE) effect. To appreciate these advances, applications focused on the detection of ions, macromolecules and bioimaging are summarized. Lastly, we will provide a brief conclusion, and will address future challenges in the rapidly growing field of fluorescent CuNCs. Multiple factors that govern the fluorescence of CuNCsDue to the size of CuNCs falls w...

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“…The water‐soluble ultrasmall (core sizes: ≈1.8 nm) luminescent PEGlyed AuNPs with ≈600 and 800 nm emissions ( Figure A), respectively, were synthesized according to our previously reported methods (Synthetic details are also shown in Figures S1 and S2, Supporting Information). [ 16 ] The corresponding fluorescence lifetimes were all microsecond time scale (≈1.0–6.8 µs, Figure S3, Supporting Information), indicating triplet excited state is involved in the emission, [ 17 ] which is favorable for 1 O 2 production due to the enhanced chance of energy transfer between triplet electrons from the AuNPs and adjacent 3 O 2 (Figure 1B).…”

Section: Resultsmentioning

confidence: 99%

Bidirectional Regulation of Singlet Oxygen Generation from Luminescent Gold Nanoparticles through Surface Manipulation

Liu

Luo

2020

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Singlet oxygen (1O2) generation has been observed from ultrasmall luminescent gold nanoparticles (AuNPs), but regulation of 1O2 generation ability from the nanosized noble metals has remained challenging. Herein, the 1O2 generation ability of ultrasmall AuNPs (d ≈ 1.8 nm) is reported to be highly correlated to the surface factors including the amount of Au(I) species and surface charge. By taking the advantages of facile in situ PEGylation, it is discovered that a high amount of Au(I) species and surface charge results in strong ability in generation of 1O2, whereas a relative low amount of Au(I) species and surface charge leads to weak ability in 1O2 production. A feasible general strategy is then developed to controllably regulate the 1O2 generation efficiency of the AuNPs through facile ligand exchange with positively‐charged or negatively‐charged thiolated ligands. The AuNPs as nanophotosensitizer for 1O2 generation in the cellular level is also demonstrated to be highly controllable through surface ligand exchange with synergistical effects of 1O2 generation ability and subcellular distribution to lysosome or mitochondria. The strategy in the bidirectional regulation of 1O2 generation from ultrasmall AuNPs provides guidance for future design of nanosized metal nanomedicine toward specific disease diagnosis and treatment.

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Amphiphilic Block Copolymer-Guided in Situ Fabrication of Stable and Highly Controlled Luminescent Copper Nanoassemblies

Cited by 57 publications

References 42 publications

Copper nanoclusters: designed synthesis, structural diversity, and multiplatform applications

Copper nanoclusters: designed synthesis, structural diversity, and multiplatform applications

Highly fluorescent copper nanoclusters for sensing and bioimaging

Bidirectional Regulation of Singlet Oxygen Generation from Luminescent Gold Nanoparticles through Surface Manipulation

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