Amphiphilic 3′‐Peptidyl‐RNA Conjugates

Terenzi, Silvia; Biala, Ewa; Nguyen-Trung, Nhat Quang; Strazewski, Peter

doi:10.1002/anie.200350926

Cited by 35 publications

(34 citation statements)

References 34 publications

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“…Recent calculations show that the probability of formation is higher than previously thought (30) and that there is limited evolvability, provided that reflexively autocatalytic networks are compartmentalized (31). This option is also compatible with the view that the RNA world may have never been clean and that amino acids and peptides played some important role in the beginning: for example, in the handling of membrane permeability (32).…”

Section: Origins Of Life: Three Early Phases Of Transitions To Cellsmentioning

confidence: 63%

“…Still, before the advent of ritualized translation, amino acids and peptides could have boosted RNA protocells by enhancing catalytic potential (55,56) or regulating membrane permeability and transport (32). When speculating on the origin of translation, one should consider that a pentanucleotide (!)…”

Section: Origins Of Life: Three Early Phases Of Transitions To Cellsmentioning

confidence: 99%

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Toward major evolutionary transitions theory 2.0

Szathmáry

2015

Proc. Natl. Acad. Sci. U.S.A.

324

343

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The impressive body of work on the major evolutionary transitions in the last 20 y calls for a reconstruction of the theory although a 2D account (evolution of informational systems and transitions in individuality) remains. Significant advances include the concept of fraternal and egalitarian transitions (lower-level units like and unlike, respectively). Multilevel selection, first without, then with, the collectives in focus is an important explanatory mechanism. Transitions are decomposed into phases of origin, maintenance, and transformation (i.e., further evolution) of the higher level units, which helps reduce the number of transitions in the revised list by two so that it is less top-heavy. After the transition, units show strong cooperation and very limited realized conflict. The origins of cells, the emergence of the genetic code and translation, the evolution of the eukaryotic cell, multicellularity, and the origin of human groups with language are reconsidered in some detail in the light of new data and considerations. Arguments are given why sex is not in the revised list as a separate transition. Some of the transitions can be recursive (e.g., plastids, multicellularity) or limited (transitions that share the usual features of major transitions without a massive phylogenetic impact, such as the microand macronuclei in ciliates). During transitions, new units of reproduction emerge, and establishment of such units requires high fidelity of reproduction (as opposed to mere replication).egalitarian transitions | fraternal transitions | multilevel selection | aggregative unit formation | recursive transitions T he book The Major Transitions in Evolution was published 20 y ago (1) and popularized 16 y ago (2). The impressive work accomplished by the interested community has made time ripe for a resynthesis of the field. In this paper, I outline the revised theory for transitions research while noting that the full account can be taken only in a new book. First, I present the key points of the theory, followed by an impressionist overview of some of the transitions, highlighting (without being all-inclusive) some of the most exciting findings pertinent to the major transitions in a revised list. In doing so, I rebuild some of the foundations of the theory. A scholarly account of all relevant contributions is beyond the scope of the present paper. For lack of space, I deliberately omit discussion on the origin of animal societies (3), except humans.

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Section: Origins Of Life: Three Early Phases Of Transitions To Cellsmentioning

confidence: 63%

Section: Origins Of Life: Three Early Phases Of Transitions To Cellsmentioning

confidence: 99%

Toward major evolutionary transitions theory 2.0

Szathmáry

2015

Proc. Natl. Acad. Sci. U.S.A.

324

343

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“…Such systems are consistent with the essential role of peptidyl-pre-tRNA molecules consisting of a peptidyl moiety bound to an RNA oligomer for the origin of the genetic code [25,205]. These peptidyl-RNA conjugates may have also served as anchoring devices allowing the RNA part to be concentrated in aggregates formed by the amphiphilic peptide moiety [26,206]. This idea is consistent with the possibilities that the main utility of the first peptides was not catalysis but simply to hold together polynucleotides [207] and that they formed the primitive apparatus from which evolved both the membrane and the cytoskeleton [208].…”

Section: Scheme 37mentioning

confidence: 69%

From the Prebiotic Synthesis of α-Amino Acids Towards a Primitive Translation Apparatus for the Synthesis of Peptides

Pascal

Boiteau

Commeyras

Prebiotic Chemistry

130

149

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“…First a base-labile branched anchor-linker is coupled to the solid support. The linker carries a primary hydroxyl group protected by dimethoxytrityl, as well as a second functionality, usually a Fmoc-protected amino group [26][27][28][29][30][31][32] (Fig. ( 3)).…”

Section: Synthetic Methodologiesmentioning

confidence: 99%

Conjugates of Oligonucleotides and Analogues with Cell Penetrating Peptides as Gene Silencing Agents

Zatsepin¹,

Turner²,

Oretskaya³

et al. 2005

CPD

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The review describes key aspects of the synthesis and biological activities of conjugates of oligonucleotides and their analogues with synthetic peptides, in particular aimed towards gene silencing applications. The common methods of synthesis of oligonucleotide-peptide conjugates (OPCs) and PNA-peptide conjugates (PPCs) are described, which include both total solid-phase and fragment coupling approaches. In addition, various applications of conjugates as gene silencing agents are outlined. These include antisense and steric block applications in mammalian cells of OPCs, PPCs and phosphorodiamidate morpholinooligonucleotide (PMO)-peptide conjugates, gene silencing in bacteria, various DNA targeting applications, and recent reports of gene silencing activities of siRNA-peptide conjugates. A table listing all peptides used as oligonucleotide conjugates for gene silencing applications is also included.

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Amphiphilic 3′‐Peptidyl‐RNA Conjugates

Cited by 35 publications

References 34 publications

Toward major evolutionary transitions theory 2.0

Toward major evolutionary transitions theory 2.0

From the Prebiotic Synthesis of α-Amino Acids Towards a Primitive Translation Apparatus for the Synthesis of Peptides

Conjugates of Oligonucleotides and Analogues with Cell Penetrating Peptides as Gene Silencing Agents

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