2003
DOI: 10.1002/anie.200350926
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Amphiphilic 3′‐Peptidyl‐RNA Conjugates

Abstract: Highly amphiphilic fragments of hydrolytically stable 3′‐peptidyl transfer RNA analogues are stepwise assembled on solid support. Their secondary structure and thermal denaturation are studied by using CD and UV spectroscopy, their supramolecular assemblage by using AFM and DLS (see picture).

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Cited by 35 publications
(34 citation statements)
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“…Recent calculations show that the probability of formation is higher than previously thought (30) and that there is limited evolvability, provided that reflexively autocatalytic networks are compartmentalized (31). This option is also compatible with the view that the RNA world may have never been clean and that amino acids and peptides played some important role in the beginning: for example, in the handling of membrane permeability (32).…”
Section: Origins Of Life: Three Early Phases Of Transitions To Cellsmentioning
confidence: 63%
See 1 more Smart Citation
“…Recent calculations show that the probability of formation is higher than previously thought (30) and that there is limited evolvability, provided that reflexively autocatalytic networks are compartmentalized (31). This option is also compatible with the view that the RNA world may have never been clean and that amino acids and peptides played some important role in the beginning: for example, in the handling of membrane permeability (32).…”
Section: Origins Of Life: Three Early Phases Of Transitions To Cellsmentioning
confidence: 63%
“…Still, before the advent of ritualized translation, amino acids and peptides could have boosted RNA protocells by enhancing catalytic potential (55,56) or regulating membrane permeability and transport (32). When speculating on the origin of translation, one should consider that a pentanucleotide (!)…”
Section: Origins Of Life: Three Early Phases Of Transitions To Cellsmentioning
confidence: 99%
“…Such systems are consistent with the essential role of peptidyl-pre-tRNA molecules consisting of a peptidyl moiety bound to an RNA oligomer for the origin of the genetic code [25,205]. These peptidyl-RNA conjugates may have also served as anchoring devices allowing the RNA part to be concentrated in aggregates formed by the amphiphilic peptide moiety [26,206]. This idea is consistent with the possibilities that the main utility of the first peptides was not catalysis but simply to hold together polynucleotides [207] and that they formed the primitive apparatus from which evolved both the membrane and the cytoskeleton [208].…”
Section: Scheme 37mentioning
confidence: 69%
“…First a base-labile branched anchor-linker is coupled to the solid support. The linker carries a primary hydroxyl group protected by dimethoxytrityl, as well as a second functionality, usually a Fmoc-protected amino group [26][27][28][29][30][31][32] (Fig. ( 3)).…”
Section: Synthetic Methodologiesmentioning
confidence: 99%