AmphiD1/β, a dopamine D1/β-adrenergic receptor from the amphioxus Branchiostoma floridae: evolutionary aspects of the catecholaminergic system during development

Candiani, Simona; Oliveri, Diana; Parodi, Monica; Castagnola, Patrizio; Pestarino, Mario

doi:10.1007/s00427-005-0019-6

Cited by 19 publications

(31 citation statements)

References 18 publications

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“…Such a proposal is not novel, as a similar pattern is seen in the duplication of catecholamine receptor sequences in the vertebrates. Amphioxus expresses a single catecholamine receptor of the DA D1 ␤-adrenergic type (Vincent et al, 1998;Candiani et al, 2005) (NCBI accessions CAA06536 and AAQ91625). All higher vertebrates (lamprey, hagfish and beyond) express two or more catecholamine receptors of this type.…”

Section: Discussionmentioning

confidence: 99%

Ancestry of neuronal monoamine transporters in the Metazoa

Caveney

Cladman

Verellen

et al. 2006

Journal of Experimental Biology

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SUMMARY Selective Na+-dependent re-uptake of biogenic monoamines at mammalian nerve synapses is accomplished by three types of solute-linked carrier family 6 (SLC6) membrane transporter with high affinity for serotonin(SERTs), dopamine (DATs) and norepinephrine (NETs). An additional SLC6 monoamine transporter (OAT), is responsible for the selective uptake of the phenolamines octopamine and tyramine by insect neurons. We have characterized a similar high-affinity phenoloamine transporter expressed in the CNS of the earthworm Lumbricus terrestris. Phylogenetic analysis of its protein sequence clusters it with both arthropod phenolamine and chordate catecholamine transporters. To clarify the relationships among metazoan monoamine transporters we identified representatives in the major branches of metazoan evolution by polymerase chain reaction (PCR)-amplifying conserved cDNA fragments from isolated nervous tissue and by analyzing available genomic data. Analysis of conserved motifs in the sequence data suggest that the presumed common ancestor of modern-day Bilateria expressed at least three functionally distinct monoamine transporters in its nervous system: a SERT currently found throughout bilaterian phyla, a DAT now restricted in distribution to protostome invertebrates and echinoderms and a third monoamine transporter (MAT), widely represented in contemporary Bilateria, that is selective for catecholamines and/or phenolamines. Chordate DATs, NETs,epinephrine transporters (ETs) and arthropod and annelid OATs all belong to the MAT clade. Contemporary invertebrate and chordate DATs belong to different SLC6 clades. Furthermore, the genes for dopamine and norepinephrine transporters of vertebrates are paralogous, apparently having arisen through duplication of an invertebrate MAT gene after the loss of an invertebrate-type DAT gene in a basal protochordate.

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Section: Discussionmentioning

confidence: 99%

Ancestry of neuronal monoamine transporters in the Metazoa

Caveney

Cladman

Verellen

et al. 2006

Journal of Experimental Biology

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“…We used the amino acid sequence of AmphiD1/b, a partially characterised aminergic GPCR from B. floridae Candiani et al 2005;Srivastava et al 2005a), as bait to pull out similar sequences. We then performed BLASTP searches using the NCBI database, constructed HMM models, and carried out phylogenetic analysis to initially characterise these receptors.…”

Section: Identification Of Novel Gpcrsmentioning

confidence: 99%

“…So far only a limited number of GPCRs have been identified and cloned from amphioxus. These include six homologues of rhodopsin (Koyanagi et al 2002), and the amine receptor (AmphiD1/b) (BLAJ5433) Candiani et al 2005;Srivastava et al 2005a). …”

Section: Introductionmentioning

confidence: 98%

Eleven new putative aminergic G-protein coupled receptors from Amphioxus (Branchiostoma floridae): identification, sequence analysis and phylogenetic relationship

et al. 2007

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We have identified eleven novel aminergic-like G-protein coupled receptor (GPCRs) sequences (named AmphiAmR1-11) by searching the genomic trace sequence database for the amphioxus species, Branchiostoma floridae. They share many of the structural motifs that have been used to characterize vertebrate and invertebrate aminergic GPCRs. A preliminary classification of these receptors has been carried out using both BLAST and Hidden Markov Model analyses. The amphioxus genome appears to express a number of D1-like dopamine receptor sequences, including one related to insect dopamine receptors. It also expresses a number of receptors that resemble invertebrate octopamine/tyramine receptors and others that resemble vertebrate alpha-adrenergic receptors. Amphioxus also expresses receptors that resemble vertebrate histamine receptors. Several of the novel receptor sequences have been identified in amphioxus cDNA libraries from a number of tissues.

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“…As described above, the avian D 1C was misidentified as 'D 1D ' due to its pharmacological and physiological properties which are significantly different from 'D 1C ' in amphibians and teleosts [Demchyshyn et al, 1995]. Similarly, the amphioxus 'AmphiD1/β' receptor has pharmacological properties similar to the vertebrate D 1 family, but it is phylogenetically closer to the vertebrate β-adrenergic receptors [Candiani et al, 2005;Burman et al, 2007Burman et al, , 2009. A more recently identified 'AmphiAmR1' is the amphioxus gene phylogenetically closest to the vertebrate D 1 , and is probably a D 1 ortholog [Burman et al, 2007;Yamamoto et al, 2013].…”

Section: Additional D 1 Family Dopamine Receptor Genes In Nonmammaliamentioning

confidence: 99%

Classification of Dopamine Receptor Genes in Vertebrates: Nine Subtypes in Osteichthyes

et al. 2015

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Dopamine neurotransmission regulates various brain functions, and its regulatory roles are mediated by two families of G protein-coupled receptors: the D₁ and D₂ receptor families. In mammals, the D₁ family comprises two receptor subtypes (D₁ and D₅), while the D₂ family comprises three receptor subtypes (D₂, D₃ and D₄). Phylogenetic analyses of dopamine receptor genes strongly suggest that the common ancestor of Osteichthyes (bony jawed vertebrates) possessed four subtypes in the D₁ family and five subtypes in the D₂ family. Mammals have secondarily lost almost half of the ancestral dopamine receptor genes, whereas nonmammalian species kept many of them. Although the mammalian situation is an exception among Osteichthyes, the current classification and characterization of dopamine receptors are based on mammalian features, which have led to confusion in the identification of dopamine receptor subtypes in nonmammalian species. Here we begin by reviewing the history of the discovery of dopamine receptors in vertebrates. The recent genome sequencing of coelacanth, gar and elephant shark led to the proposal of a refined scenario of evolution of dopamine receptor genes. We also discuss a current problem of nomenclature of dopamine receptors. Following the official nomenclature of mammalian dopamine receptors from D₁ to D₅, we propose to name newly identified receptor subtypes from D₆ to D₉ in order to facilitate the use of an identical name for orthologous genes among different species. To promote a nomenclature change which allows distinguishing the two dopamine receptor families, a nomenclature consortium is needed. This comparative perspective is crucial to correctly interpret data obtained in animal studies on dopamine-related brain disorders, and more fundamentally, to understand the characteristics of dopamine neurotransmission in vertebrates.

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AmphiD1/β, a dopamine D1/β-adrenergic receptor from the amphioxus Branchiostoma floridae: evolutionary aspects of the catecholaminergic system during development

Cited by 19 publications

References 18 publications

Ancestry of neuronal monoamine transporters in the Metazoa

Ancestry of neuronal monoamine transporters in the Metazoa

Eleven new putative aminergic G-protein coupled receptors from Amphioxus (Branchiostoma floridae): identification, sequence analysis and phylogenetic relationship

Classification of Dopamine Receptor Genes in Vertebrates: Nine Subtypes in Osteichthyes

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