Amphichoterpenoids A–C, unprecedented picoline-derived meroterpenoids from the ascidian-derived fungus Amphichorda felina SYSU-MS7908

Penaloidines A and B: two unprecedented pyridine alkaloids from Penicillium sp. KYJ-6

“…The data summarized above indicate that 1 is a meroterpenoid pyridine alkaloid with a tricyclic ring system. 9,10…”

“…Pyridines are privileged scaffolds in medicinal chemistry, 5 and the nitrogen atom in pyridine plays a crucial role in the pharmacological profiles of many drugs that contain this heterocycle. 6 Thus, pyridine alkaloids display rich structural diversity and widespread bioactivity, such as antiallergic dysivillosins, 7 cardioprotective scrophularianines, 8 anti-butyrylcholinesterase terreuspyridine 9 and anti-acetylcholinesterase amphichoterpenoids, 10 which have attracted widespread attention from chemists and pharmacologists to further explore their structural diversity, biosynthesis and bioactivities. [11][12][13][14][15] Fungi have been widely recognized as a new frontier in natural product research.…”

“…The data summarized above indicate that 1 is a meroterpenoid pyridine alkaloid with a tricyclic ring system. 9,10 Further analyses of the 1 H-1 H COSY and HMBC spectra led to the elucidation of the planar structure of 1. The 1 H-1 H COSY spectrum indicated the presence of three independent spin systems, H-1/H-10, H-6/H-7/H-13 and H-11/H-12 (Fig.…”

Mono- and Dimeric Xanthones with Anti-Glioma and Anti-Inflammatory Activities from the Ascidian-Derived Fungus Diaporthe sp. SYSU-MS4722

“…In the past five years, our research group has focused on the bioactive secondary metabolites of ascidian-derived fungi collected from the South China Sea [5,[13][14][15][16]. A marine-derived fungus Diaporthe sp.…”

Genome Mining of α-Pyrone Natural Products from Ascidian-Derived Fungus Amphichordafelina SYSU-MS7908

“…Discovering novel secondary metabolites from marine-derived fungi has been our group’s long-term research interest [ 8 , 9 , 10 , 11 ]. The fungus A mphichorda felina SYSU-MS7908 was isolated from a marine ascidian Styelaplicata and fermentation under standard laboratory conditions mainly gave meroterpenoids and nonribosomal peptides [ 12 , 13 ]. To probe the biosynthetic potential of A. felina SYSU-MS7908, the genome was sequenced by Illumina second-generation sequencing, and the assembled genome was analyzed by the antibiotics and secondary metabolite analysis shell (antiSMASH) [ 14 ].…”