Amphibian Chytridiomycosis in the Oregon Spotted Frog (RANA PRETIOSA) IN WASHINGTON STATE, USA

Hayes, Marc P.; Rombough, Christopher J.; Padgett-Flohr, Gretchen E.; Hallock, Lisa; Johnson, James E.; Wagner, Róbert; Engler, Joseph D.

doi:10.1898/nwn08-28.1

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…Population declines due to fatal chytridiomycosis have been particularly severe among ranids from California and the Pacific northwest. Species in which B. dendrobatidis infection has been detected and in which fatalities due to chytridiomycosis has been observed include R. aurora (Nieto et al 2007), R. boylii (Padgett-Flohr and Hopkins 2009), R. cascadae (Garcia et al 2006), Rana draytonii (Padgett-Flohr and Hopkins 2009), Rana luteiventris (Pearl et al 2007), R. muscosa (Fellers et al 2001;Rachowicz et al 2006), Rana pretiosa (Hayes et al 2009), and Rana sierra (Morgan et al 2007). Chytridiomycosis is also prevalent in native Arizona frogs and has led to mortalities and population declines among L. yavapaiensis and Lithobates chiricahuensis (Bradley et al 2002).…”

Section: The Importance Of Dermal Antimicrobial Peptides In Protectiomentioning

confidence: 99%

The contribution of skin antimicrobial peptides to the system of innate immunity in anurans

2010

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Cationic peptides with the propensity to adopt an amphipathic α-helical conformation in a membrane-mimetic environment are synthesized in the skins of many species of anurans (frogs and toads). These peptides frequently display cytolytic activities against a range of pathogenic bacteria and fungi consistent with the idea that they play a role in the host's system of innate immunity. However, the importance of the peptides in the survival strategy of the animal is not clearly understood. It is a common misconception that antimicrobial peptides are synthesized in the skins of all anurans. In fact, the species distribution is sporadic suggesting that their production may confer some evolutionary advantage to the organism but is not necessary for survival. Although growth inhibitory activity against the chytrid fungus Batrachochytrium dendrobatidis, responsible for anuran population declines worldwide, has been demonstrated in vitro, the ability of frog skin antimicrobial peptides to protect the animal in the wild appears to be limited and there is no clear correlation between their production by a species and its resistance to fatal chytridiomycosis. The low potency of many frog skin antimicrobial peptides is consistent with the hypothesis that cutaneous symbiotic bacteria may provide the major system of defense against pathogenic microorganisms in the environment with antimicrobial peptides assuming a supplementary role in some species.

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Section: The Importance Of Dermal Antimicrobial Peptides In Protectiomentioning

confidence: 99%

The contribution of skin antimicrobial peptides to the system of innate immunity in anurans

2010

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“…This disease, caused by the chytrid fungus (Batrachochytrium dendrobatidis), is implicated in the widespread decline of anurans. The fungus and disease has been documented within the Columbia Basin (Hayes et al 2009). This disease has caused many species to be listed as threatened or endangered, and continued monitoring of populations on the Hanford Site is necessary to ensure that these populations continue to exist.…”

Section: Tablesmentioning

confidence: 99%