Amphetamine stereotypy, the basal ganglia, and the “selection problem”

Wolgin, David L.

doi:10.1016/j.bbr.2011.11.003

Cited by 24 publications

(13 citation statements)

References 108 publications

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“…In contrast, hyperdopaminergic mice (a model of OCD reviewed in Section 4) perform more frequent, behaviorally rigid grooming chains (Berridge et al, 2005). Further, cocaine and amphetamine, which both increase catecholamines including dopamine, induce repetitive, stereotypic behaviors in rodents (Wolgin, 2012). This is likely via a D1 receptor-dependent process, as D1 agonists induce stereotypic movements, but D2 agonists do not (Berridge & Aldridge, 2000a, 2000b; Taylor, Rajbhandari, Berridge, & Aldridge, 2010).…”

Section: Striatal Organization and Functionmentioning

confidence: 99%

Mouse Models of Neurodevelopmental Disease of the Basal Ganglia and Associated Circuits

Pappas

Leventhal

Albin

et al. 2014

Current Topics in Developmental Biology

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This chapter focuses on neurodevelopmental diseases that are tightly linked to abnormal function of the striatum and connected structures. We begin with an overview of three representative diseases in which striatal dysfunction plays a key role—Tourette syndrome and obsessive-compulsive disorder, Rett's syndrome, and primary dystonia. These diseases highlight distinct etiologies that disrupt striatal integrity and function during development, and showcase the varied clinical manifestations of striatal dysfunction. We then review striatal organization and function, including evidence for striatal roles in online motor control/action selection, reinforcement learning, habit formation, and action sequencing. A key barrier to progress has been the relative lack of animal models of these diseases, though recently there has been considerable progress. We review these efforts, including their relative merits providing insight into disease pathogenesis, disease symptomatology, and basal ganglia function.

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Section: Striatal Organization and Functionmentioning

confidence: 99%

Mouse Models of Neurodevelopmental Disease of the Basal Ganglia and Associated Circuits

Pappas

Leventhal

Albin

et al. 2014

Current Topics in Developmental Biology

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“…In addition, QNP-treated rats also display environment-dependent perseveration in a spontaneous alternation task (Einat and Szechtman, 1995). QNP-sensitization is not associated with stereotypy of body movements such as after application of amphetamine (Wolgin, 2012), but only with path stereotypy and checking in an enriched open-field (Szechtman et al, 1998). Based on the striking similarity between QNP-sensitized behavior in rats and obsessive–compulsive symptoms in humans, it was proposed that sensitization with QNP may serve as a useful rat model of OCD.…”

Section: Introductionmentioning

confidence: 99%

Spatial Reversal Learning in Chronically Sensitized Rats and in Undrugged Sensitized Rats with Dopamine D2-Like Receptor Agonist Quinpirole

Hatalova

Radostová

Pistikova

et al. 2014

Front. Behav. Neurosci.

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Dopamine plays a role in generating flexible adaptive responses in changing environments. Chronic administration of D2-like agonist quinpirole (QNP) induces behavioral sensitization and stereotypical behaviors reminiscent of obsessive–compulsive disorder (OCD). Some of these symptoms persist even after QNP discontinuation. In QNP-sensitization, perseverative behavior has often been implicated. To test the effect of QNP-sensitization on reversal learning and its association with perseveration we selected an aversively motivated hippocampus-dependent task, active place avoidance on a Carousel. Performance was measured as the number of entrances into a to-be-avoided sector (errors). We tested separately QNP-sensitized rats in QNP-drugged and QNP-undrugged state in acquisition and reversal tasks on the Carousel. In acquisition learning there were no significant differences between groups and their respective controls. In reversal, QNP-sensitized drugged rats showed a robust but transient increase in number of errors compared to controls. QNP-sensitized rats in an undrugged state were not overtly different from the control animals but displayed an altered learning manifested by more errors at the beginning compensated by quicker learning in the second session compared to control animals. Importantly, performance was not associated with perseveration in neither QNP-sensitized drugged nor QNP-sensitized undrugged animals. The present results show that chronic QNP treatment induces robust reversal learning deficit only when the substance is continuously administered, and suggest that QNP animal model of OCD is also feasible model of cognitive alterations in this disorder.

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“…Another important limitation is that the MPH and AMPH doses employed were not equated for their level of drug-induced motor stimulation. Moreover, the dose of amphetamine use in Experiment 2 induces stereotypy (Salisbury & Wolgin, 1985;Wolgin, 2012), yet the method of analyzing motor stimulation employed (photocell beam breaks) does not allow measurement of stereotypy. It is possible, thus, that the measures of amphetamine-induced locomotion were confounded, and probably reduced, by this drug increasing stereotypy.…”

Section: Discussionmentioning

confidence: 99%

Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats

et al. 2018

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IntroductionThere has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention‐deficit hyperactivity disorder (ADHD) in these developmental stages, during which ethanol initiation and escalation often occur.MethodsThis study assessed the effects of repeated d‐amphetamine (AMPH) or methylphenidate (MPH) treatment during adolescence [male and female Wistar rats, between postnatal day (PD) 28 to PD34, approximately] on the initiation of ethanol intake during a later section of adolescence (PD35 to PD40).ResultsAmphetamine and MPH exerted reliable acute motor stimulant effects, but there was no indication of sensitized motor or anxiety responses. MPH did not affect dopamine (DA) levels, whereas AMPH significantly reduced insular levels of DA in both sexes and norepinephrine levels in females only. Repeated treatment with AMPH, but not with MPH, enhanced ethanol intake during late adolescence in male, but not in female, rats.ConclusionA short treatment with AMPH during adolescence significantly altered DA levels in the insula, both in male and females, and significantly enhanced ethanol intake in males. The present results suggest that, in adolescent males, a very brief history of AMPH exposure can facilitate the initiation of ethanol intake.

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Amphetamine stereotypy, the basal ganglia, and the “selection problem”

Cited by 24 publications

References 108 publications

Mouse Models of Neurodevelopmental Disease of the Basal Ganglia and Associated Circuits

Mouse Models of Neurodevelopmental Disease of the Basal Ganglia and Associated Circuits

Spatial Reversal Learning in Chronically Sensitized Rats and in Undrugged Sensitized Rats with Dopamine D2-Like Receptor Agonist Quinpirole

Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats

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