Amphetamine-induced modification of quinine palatability: Analysis by the taste reactivity test

Parker, Linda A.; Leeb, Kira

doi:10.1016/0091-3057(94)90137-6

Cited by 15 publications

(5 citation statements)

References 39 publications

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“…Similar effects have been found following the systemic administration of neuroleptic drugs—acting primarily on DAergic sites— which also failed to alter liking responses (Kaczmarek and Kiefer, 2000; Parker and Leeb, 1994; Pecina et al, 1997). Finally, DA burst-firing—which commonly occurs in response to unexpected rewards—ceases after the previously unexpected reward becomes predicted, despite the fact that the hedonic value of the predicted reward is presumably intact (Berridge, 2007; Schultz, 2006; Schultz et al, 1997).…”

Section: Neurobiological Bases Of Motivational and Consummatory Ansupporting

confidence: 64%

Reconsidering anhedonia in depression: Lessons from translational neuroscience

Treadway

Zald

2011

Neuroscience & Biobehavioral Reviews

1,234

986

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Anhedonia is a core symptom of major depressive disorder (MDD), the neurobiological mechanisms of which remain poorly understood. Despite decades of speculation regarding the role of dopamine (DA) in anhedonic symptoms, empirical evidence has remained elusive, with frequent reports of contradictory findings. In the present review, we argue that this has resulted from an underspecified definition of anhedonia, which has failed to dissociate between consummatory and motivational aspects of reward behavior. Given substantial preclinical evidence that DA is involved primarily in motivational aspects of reward, we suggest that a refined definition of anhedonia that distinguishes between deficits in pleasure and motivation is essential for the purposes of identifying its neurobiological substrates. Moreover, bridging the gap between preclinical and clinical models of anhedonia may require moving away from the conceptualization of anhedonia as a steady-state, mood-like phenomena. Consequently, we introduce the term “decisional anhedonia” to address the influence of anhedonia on reward decision-making. These proposed modifications to the theoretical definition of anhedonia have implications for research, assessment and treatment of MDD.

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Section: Neurobiological Bases Of Motivational and Consummatory Ansupporting

confidence: 64%

Reconsidering anhedonia in depression: Lessons from translational neuroscience

Treadway

Zald

2011

Neuroscience & Biobehavioral Reviews

1,234

986

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“…Other taste reactivity studies in the 1990s found that pharmacological blockade of dopamine neurotransmission by systemic administration of neuroleptic drugs, such as pimozide, similarly failed to shift the hedonic impact of tastes toward anhedonic 'disliking', at least, not when sensorimotor factors were controlled (Kaczmarek and Kiefer 2000;Parker and Leeb 1994;Peciña et al 1997). The final conclusion of those studies was that dopamine was not necessary for normal 'liking' reactions to sweetness.…”

Section: Analysis Of Hedonia Hypothesismentioning

confidence: 93%

The debate over dopamine’s role in reward: the case for incentive salience

2006

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“…Further, given some discrepancy in the literature regarding the role of dopamine in mediating palatability reactions (Leeb et al 1991;Parker and Leeb 1994;Pecina et al 1997;Higgs and Cooper 2000;Genn et al 2003;Pecina et al 2003;D'Aquila 2010), we also incorporated evaluation of flupenthixol's effect on reward palatability (or "liking") into the experimental design, in addition to a measure of the Pavlovian goal approach (or "wanting").…”

mentioning

confidence: 99%

Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling

Wassum¹,

Ostlund²,

Balleine³

et al. 2011

Learn. Mem.

131

150

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Here we attempted to clarify the role of dopamine signaling in reward seeking. In Experiment 1, we assessed the effects of the dopamine D(1)/D(2) receptor antagonist flupenthixol (0.5 mg/kg i.p.) on Pavlovian incentive motivation and found that flupenthixol blocked the ability of a conditioned stimulus to enhance both goal approach and instrumental performance (Pavlovian-to-instrumental transfer). In Experiment 2 we assessed the effects of flupenthixol on reward palatability during post-training noncontingent re-exposure to the sucrose reward in either a control 3-h or novel 23-h food-deprived state. Flupenthixol, although effective in blocking the Pavlovian goal approach, was without effect on palatability or the increase in reward palatability induced by the upshift in motivational state. This noncontingent re-exposure provided an opportunity for instrumental incentive learning, the process by which rats encode the value of a reward for use in updating reward-seeking actions. Flupenthixol administered prior to the instrumental incentive learning opportunity did not affect the increase in subsequent off-drug reward-seeking actions induced by that experience. These data suggest that although dopamine signaling is necessary for Pavlovian incentive motivation, it is not necessary for changes in reward experience, or for the instrumental incentive learning process that translates this experience into the incentive value used to drive reward-seeking actions, and provide further evidence that Pavlovian and instrumental incentive learning processes are dissociable.

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Amphetamine-induced modification of quinine palatability: Analysis by the taste reactivity test

Cited by 15 publications

References 39 publications

Reconsidering anhedonia in depression: Lessons from translational neuroscience

Reconsidering anhedonia in depression: Lessons from translational neuroscience

The debate over dopamine’s role in reward: the case for incentive salience

Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling

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