Amperometric sensing of sodium, calcium and potassium in biological fluids using a microhole supported liquid/gel interface

Diba, Farhana Sharmin; Lee, Hye Jin

doi:10.1016/j.jelechem.2016.02.045

Cited by 14 publications

(6 citation statements)

References 36 publications

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“…In both systems, the transfer peaks shift to more positive potentials with decreasing cation concentration, which is a typical behavior observed in potentiometric ISEs. The linear correlation between the midpoint potential ( E mid ) and ion concentration (Figure S9) exhibits a non-Nernstian slope, although it is consistent with literature reports describing facilitated ion transfer in 2-electrode systems. , …”

Section: Results and Discussionsupporting

confidence: 90%

“…The linear correlation between the midpoint potential (E mid ) and ion concentration (Figure S9) exhibits a non-Nernstian slope, although it is consistent with literature reports describing facilitated ion transfer in 2-electrode systems. 40,41 As mentioned before, we showed that the chromatography paper contains trace amounts of sodium ions. Using facilitated cation transfer, we evaluated the release of ions from the paper structure (without added electrolyte).…”

Section: ■ Results and Discussionmentioning

confidence: 64%

Section: Results and Discussionmentioning

confidence: 99%

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Ion Transfer Voltammetry with an Electrochemical Pen

et al. 2020

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We present a new electrochemical system that combines paper-based sensing and ion-transfer voltammetry, bringing the latter a step closer toward point-of-care applications. Studies at the interface between two immiscible electrolyte solutions (ITIES) are often performed to detect redox-inactive species; unfortunately, due to the inherent instability of the interface, it is rather poorly explored outside specialized laboratories. Here, we address this limitation by combining a pen-like device containing the gelled organic phase with a paper-supported aqueous phase. This combination makes the system more user-friendly, potentially low-cost, and easy to assemble. We show the applicability of the new cell to analyze both simple and ionophore-facilitated transfer of ions and proteins, preconcentration of species, and analysis of mixtures through combination with paper chromatography. The native ion content of the paper also enabled measurements without added electrolytes. Those studies could broaden the scope for the application of the label-free electrochemical detection of nonredox-active species at points-of-need.

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Section: Results and Discussionsupporting

confidence: 90%

Section: ■ Results and Discussionmentioning

confidence: 64%

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Ion Transfer Voltammetry with an Electrochemical Pen

et al. 2020

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“…[21][22] Furthermore, the wide concentration range of operation has been demonstrated with multi-modal techniques such as chronoamperometry and differential pulse voltammetry ensuring amenability for AI-based detection protocols. [23][24][25] A major challenge in realizing such sensors is their reliability and reproducibility of operation, particularly in widely varying real-time, Please do not adjust margins Please do not adjust margins on-field conditions. This is mainly controlled by the uniformity in surface coverage of the receptors within (a) a sensor and (b) across multiple batches of sensors.…”

Section: Introductionmentioning

confidence: 99%

Scalable approach towards specific and ultrasensitive cation sensing under harsh environmental conditions by engineering the analyte–transducer interface

Mondal

Subramaniam

2021

Nanoscale Adv.

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“…However, the sensors involving a dynamic and fluidic biphasic interface lack sufficient mechanical stability and reproducibility, which significantly hinders their practical applications. An elegant approach to overcome the stability problem is to solidify one of two phases, for example, using polyvinyl chloride (PVC) as an organic gelling agent, , while using a gelled organic phase brings about a highly uncompensated phase resistance (namely, iR drop). , As reported previously, the iR drop can be effectively minimized by the miniaturization of ITIES as in the ultramicroelectrode electrochemistry. Meanwhile, the analytical sensitivity can be improved thanks to the enhanced mass transport at the microscale/nanoscale interfaces .…”

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confidence: 99%

Portable Sensor for the Detection of Choline and Its Derivatives Based on Silica Isoporous Membrane and Gellified Nanointerfaces

Xie

Huang

2017

ACS Sens.

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A portable amperometric ion sensor was fabricated by integrating silica isoporous membrane (SIM) and organogel composed of polyvinyl chloride and 1,2-dichloroethane (PVC-DCE) on a 3D-printed polymer chip. The detection of ionic species in aqueous samples could be accomplished by adding a microliter of sample droplet to the sensor and by identifying the ion-transfer potential and current magnitude at the water/organogel interface array templated by SIM. Thanks to the ultrasmall channel size (2-3 nm in diameter), high channel density (4 × 10 μm), and ultrathin thickness (80 nm) of SIM, the ensemble of nanoscopic water/organogel (nano-W/Gel) interface array behaved like a microinterface with two back-to-back hemispherical mass diffusion zones. So, the heterogeneous ion-transfer across the nano-W/Gel interface array generated a steady-state sigmoidal current wave. The detection of choline (Ch) and its derivatives, including acetylcholine (ACh), benzoylcholine (BCh), and atropine (AP), in aqueous samples was examined with this portable sensor. Using differential pulse stripping voltammetry (DPSV), the quantification of these analytes was achieved with a limit of detection (LOD) down to 1 μM. Moreover, the portable ion sensor was insensitive to various potential interferents that might coexist in vivo, owing to size-/charge-based selectivity and antifouling capacity of SIM. With this priority, the portable ion sensor was able to quantitatively determine Ch and its derivatives in diluted urine and blood samples. The LODs for Ch, ACh, AP, and BCh in urine were 1.12, 1.30, 1.08, and 0.99 μM, and those for blood samples were 3.61, 3.38, 2.32, and 1.81 μM, respectively.

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Amperometric sensing of sodium, calcium and potassium in biological fluids using a microhole supported liquid/gel interface

Cited by 14 publications

References 36 publications

Ion Transfer Voltammetry with an Electrochemical Pen

Ion Transfer Voltammetry with an Electrochemical Pen

Scalable approach towards specific and ultrasensitive cation sensing under harsh environmental conditions by engineering the analyte–transducer interface

Portable Sensor for the Detection of Choline and Its Derivatives Based on Silica Isoporous Membrane and Gellified Nanointerfaces

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