Amperometric Sarcosine Biosensors Based on Electrodeposited Conductive Films Contain Indole‐6‐carboxylic Acid

Zhang, Xiaofang; Chen, Jing; Qia, Wang; Du, Bing; Fan, Gao-Chao; Zheng, Weidong; Yang, Haipeng; Xu, Tailin

doi:10.1002/elan.202100225

Cited by 11 publications

(3 citation statements)

References 45 publications

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“…Chitosan@Glassycarbon electrode, Nafion@Glassycarbon electrode and PEDOT‐IA/Pt/MnPO 4 /GlassycarbonElectrode each had residual current signals towards 100 μM amino acid that are 27.56 %, 19.74 %, and 6.91 %, accordingly, under the identical circumstances. for the mentioned findings demonstrate that PEDOT‐IA/Pt/MnPO 4 /Glassy Carbon Electrode has a significantly greater anti‐interference ability than nafion and chitosan [87] …”

Section: Carbon Quantum Dots and Graphene Quantum Dots As A Probe For...mentioning

confidence: 74%

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Exploring the Significance of Carbon Quantum Dots and Graphene Quantum Dots in Sarcosine Sensing: A Key Biomarker for Prognosticating Prostate Cancer

Chaudhari,

Patil,

Nangare

et al. 2024

ChemistrySelect

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Luminescent carbon nanoparticles, such as carbon quantum dots (CQDs) and graphene quantum dots (GQDs), are increasingly utilized for sarcosine detection due to their exceptional water permeability, sustained luminescence, and biocompatibility. Sarcosine as a biomarker holds significance for therapeutic purposes and disease identification. Carbon‐based sensors offer eco‐friendliness, recyclability, and affordability, making them sustainable for sensing applications across various domains. Despite the widespread use of standard sensors for sarcosine measurement, they face limitations. This paper presents a focused review of recent developments in biosensors utilizing luminescent carbon quantum dots and graphene quantum dots for sarcosine detection. Key processes are characterized by their selectivity and sensitivity to different forms of sarcosine and interfering substances like metallic ions and amino acids. The significant reaction mechanisms and detection methods for sarcosine are outlined and compared. Additionally, the challenges in developing functionalized CQDs and GQDs for further investigation are explored. In summary, luminescent carbon nanoparticles offer a promising avenue for sarcosine detection, addressing limitations of standard sensors through their cost‐effectiveness, sensitivity, and rapid response, thus holding potential for diverse sensing applications.

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Section: Carbon Quantum Dots and Graphene Quantum Dots As A Probe For...mentioning

confidence: 74%

“…for the mentioned findings demonstrate that PEDOT-IA/Pt/MnPO 4 /Glassy Carbon Electrode has a significantly greater anti-interference ability than nafion and chitosan. [87] Figure 6. Schematic presentation of sensing of sarcosine using A-IDA.…”

Section: Amperometric-based Sarcosine Sensormentioning

confidence: 99%

Exploring the Significance of Carbon Quantum Dots and Graphene Quantum Dots in Sarcosine Sensing: A Key Biomarker for Prognosticating Prostate Cancer

Chaudhari,

Patil,

Nangare

et al. 2024

ChemistrySelect

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“…Characterisation of electrochemical properties of the modified electrodes.-From the catalytic principles of sarcosine biosensors, an excellent sarcosine biosensor has the following three requirements for its electrocatalytic material: high ability to conduct electrons, excellent catalytic response to H 2 O 2 , and a diffusioncontrolled kinetic process for its catalytic reaction. [32][33][34][35][36][37][38] Electrocatalysis experiments with H 2 O 2 were performed on the modified electrodes to initially determine whether they could be further modified as enzyme biosensors. The results are shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Sarcosine Biosensor Based on Pt/g-C₃N₄ Nanocomposites with High Electrocatalytic Activity

Feng

Chen

Shi

et al. 2022

ECS J. Solid State Sci. Technol.

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Sarcosine has been shown to be a new biomarker for prostate cancer that is superior to prostate-specific antigen (PSA). By detecting the concentration of sarcosine in the human body, accurate screening and diagnosis of prostate cancer can be achieved in clinical practice. However, the sarcosine level is extremely low in human serum or urine, and accurate detection of sarcosine concentration is difficult. More work is needed to prepare sarcosine biosensors with good anti-interference performance. Here, we prepared a sarcosine biosensor using a highly electrocatalytically active nanocomposite comprising platinum/carbon nitride (Pt/g-C3N4) as the electrode modification material. The porous lamellar graphite phase carbon nitride (g-C3N4) prevents the agglomeration of Pt nanoparticles and keeps the Pt nanoparticles in a highly dispersed state. The constructed sarcosine biosensor achieves high sensitivity and can selectively detect low concentrations of sarcosine. Its linear detection range is 2-70 μM, and the limit of detection (LOD) is 0.8 μM (S/N=3). The prepared sarcosine biosensor shows relatively good performance in terms of resistance to interference caused by electroactive substances and provides the potential to be applied in serum for accurate detection of sarcosine.

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Nanomaterials‐Based Biosensors for the Detection of Prostate Cancer Biomarkers: Recent Trends and Future Perspective

Singh

Hara³

et al. 2023

Adv Materials Technologies

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Cancer is among the leading causes of death and an important barrier to improving life expectancy globally. Prostate cancer is the second most common cancer in men worldwide. The detection of biomarkers in body fluids is the key topic for the diagnosis and prognosis of prostate cancer. Despite advances in prostate cancer detection methods, therapeutic agents and new biomarkers, prostate cancer remains a serious challenge. Prostate‐specific antigen (PSA) is widely recognized as an important biomarker for the diagnosis of prostate cancer although researchers have also investigated the use of alternative biomarkers. Design and development of novel biosensors for prostate cancer detection has become a hot research area with advances in nanotechnology aiding biosensor development. This article reviews recent achievements and progress that nanomaterials and nanotechnology have made in biomarkers based biosensors for prostate cancer detection and covers: i) PSA‐targeted biosensors (immunosensors, aptamer‐based, peptide‐based and nanopore‐based biosensors), ii) sarcosine oxidase‐targeted biosensors, iii) other biomarkers based biosensors (prostate cancer antigen 3 (PCA3), vascular endothelial growth factor (VEGF) and prostate‐specific membrane antigen (PSMA)) including dual biomarkers based biosensors (PSA‐VEGF, PSA‐PSMA, PSA‐PCA3 and PSA‐sarcosine). The aim of this review is to provide insights into how nanomaterials in combination with various biomarkers are now aiding biosensor development in prostate cancer diagnostics.

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Amperometric Sarcosine Biosensors Based on Electrodeposited Conductive Films Contain Indole‐6‐carboxylic Acid

Cited by 11 publications

References 45 publications

Exploring the Significance of Carbon Quantum Dots and Graphene Quantum Dots in Sarcosine Sensing: A Key Biomarker for Prognosticating Prostate Cancer

Exploring the Significance of Carbon Quantum Dots and Graphene Quantum Dots in Sarcosine Sensing: A Key Biomarker for Prognosticating Prostate Cancer

Sarcosine Biosensor Based on Pt/g-C₃N₄ Nanocomposites with High Electrocatalytic Activity

Nanomaterials‐Based Biosensors for the Detection of Prostate Cancer Biomarkers: Recent Trends and Future Perspective

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Amperometric Sarcosine Biosensors Based on Electrodeposited Conductive Films Contain Indole‐6‐carboxylic Acid

Cited by 11 publications

References 45 publications

Exploring the Significance of Carbon Quantum Dots and Graphene Quantum Dots in Sarcosine Sensing: A Key Biomarker for Prognosticating Prostate Cancer

Exploring the Significance of Carbon Quantum Dots and Graphene Quantum Dots in Sarcosine Sensing: A Key Biomarker for Prognosticating Prostate Cancer

Sarcosine Biosensor Based on Pt/g-C3N4 Nanocomposites with High Electrocatalytic Activity

Nanomaterials‐Based Biosensors for the Detection of Prostate Cancer Biomarkers: Recent Trends and Future Perspective

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Sarcosine Biosensor Based on Pt/g-C₃N₄ Nanocomposites with High Electrocatalytic Activity