AMPA receptors and motivation for drug: effect of the selective antagonist NBQX on behavioural sensitization and on self-administration in mice

Jackson, Anne; Mead, Andy N.; Rocha, Beatriz A.; Stephens, David

doi:10.1097/00008877-199809000-00009

Cited by 39 publications

(19 citation statements)

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“…Infusing AMPA into the NAcc produces enhanced locomotion in rats exposed to cocaine 2-3 weeks earlier (Bell and Kalivas, 1996;Pierce et al, 1996a) and AMPA receptor antagonists prevent the expression of locomotor sensitization by amphetamine (Karler et al, 1991;Tzschentke and Schmidt, 1997;Mead and Stephens, 1998;cf, Li et al, 1997) and cocaine (Pierce et al, 1996a;Jackson et al, 1998;Bell et al, 2000;cf, Karler et al, 1994;Li et al, 1997). The present results are consistent with these findings and extend them to the reinstatement of drug seeking.…”

Section: Discussionsupporting

confidence: 86%

“…For example, infusions of AMPA into the NAcc produce enhanced locomotion in animals exposed to cocaine 2-3 weeks earlier (Bell and Kalivas, 1996;Pierce et al, 1996a) and AMPA receptor antagonists administered systemically (Karler et al, 1991;Tzschentke and Schmidt, 1997;Jackson et al, 1998;Mead and Stephens, 1998;cf, Karler et al, 1994;Li et al, 1997) or into the NAcc (Pierce et al, 1996a;Bell et al, 2000) prevent the expression of locomotor sensitization by amphetamine (AMPH) and cocaine. When taken in light of the above findings and others showing that sensitization enhances the pursuit and self-administration of drugs (Vezina, 2004), these results suggest that previous exposure to psychostimulants should enhance the ability of NAcc AMPA to reinstate drug seeking.…”

Section: Introductionmentioning

confidence: 99%

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Previous Exposure to Psychostimulants Enhances the Reinstatement of Cocaine Seeking by Nucleus Accumbens AMPA

Suto

Tanabe

Austin

et al. 2004

Neuropsychopharmacol

103

100

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The effect of previous exposure to psychostimulants on the subsequent self-administration of cocaine as well as reinstatement of this behavior by priming infusions of AMPA into the nucleus accumbens (NAcc) was examined. Rats were exposed to five injections, one injection every third day, of either saline or amphetamine (AMPH: 1.5 mg/kg, i.p.). Starting 10 days later, they were trained to selfadminister cocaine (0.3 mg/kg/infusion, i.v.) and subsequently tested under a progressive ratio (PR) schedule for 4 consecutive days. As expected, rats exposed to AMPH worked more and obtained more cocaine infusions than saline exposed controls on the PR test sessions. Following daily extinction sessions during which saline was substituted for cocaine, the effect of priming infusions of AMPA (0.0, 0.08, or 0.8 nmol/0.5 ml/side) into the NAcc was then examined on two tests: one conducted 4 days after the last cocaine PR test session (2-3 weeks after the last AMPH exposure injection) and the next 4 weeks later. Consistent with previous reports, NAcc AMPA dosedependently reinstated cocaine seeking on both tests regardless of exposure condition. Importantly, this priming effect of NAcc AMPA was significantly enhanced in AMPH compared to saline exposed rats on the first test conducted 2-3 weeks after AMPH. On the second test, conducted 4 weeks after cocaine, reinstatement was similarly enhanced in both groups to levels observed on the first test in AMPH exposed rats. These results indicate that both noncontingent (AMPH) and contingent (cocaine) exposure to psychostimulants enhances the reinstatement of cocaine seeking by NAcc AMPA and appears to do so in a time-dependent manner.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Previous Exposure to Psychostimulants Enhances the Reinstatement of Cocaine Seeking by Nucleus Accumbens AMPA

Suto

Tanabe

Austin

et al. 2004

Neuropsychopharmacol

103

100

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“…AMPA and NMDA receptor antagonists have been shown to attenuate also the expression of other conditioned and drug-related behaviors. For example, AMPA antagonists such as CNQX, DNQX, NBQX, and GYKI52466 reduced the expression of conditioned place preference and behavioral sensitization (Cervo and Samanin, 1995;Tzschentke and Schmidt, 1997;Jackson et al, 1998;Stephens, 1998, 1999; but see Li et al, 1997). NMDA antagonists, however, seem to differ in their ability to modulate these behaviors.…”

Section: Discussionmentioning

confidence: 99%

“…Supporting the contribution of AMPA/kainate receptors in cocaine-environment conditioning, AMPA/kainate receptor antagonists have been reported to diminish cocaineconditioned locomotion, cocaine-induced place preference, and cocaine seeking under a second-order schedule of reinforcement (Cervo and Samanin, 1995;Jackson et al, 1998;Bäckström and Hyytiä, 2003), whereas evidence for the involvement of NMDA receptors in cocaine-seeking behavior is less consistent (De Vries et al, 1998;Kotlinska and Biala, 2000). In addition to the suggested role of ionotropic AMPA/kainate and NMDA glutamate receptors in conditioned influences on drug seeking, evidence is accumulating that the metabotropic glutamate receptors (mGluRs) may also be implicated.…”

Section: Introductionmentioning

confidence: 99%

Ionotropic and Metabotropic Glutamate Receptor Antagonism Attenuates Cue-Induced Cocaine Seeking

Bäckström

Hyytiä

2005

Neuropsychopharmacol

161

121

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Neuroanatomical and pharmacological evidence implicates glutamate transmission in drug-environment conditioning that partly controls drug seeking and relapse. Glutamate receptors could be targets for pharmacological attenuation of the motivational properties of drugpaired cues and for relapse prevention. The purpose of the present study was therefore to investigate the involvement of ionotropic and metabotropic glutamate receptor subtypes in cue-induced reinstatement of cocaine-seeking behavior. Rats were trained to selfadminister cocaine using a second-order schedule of reinforcement (FR4(FR5:S)) under which a compound stimulus (light and tone) associated with cocaine infusions was presented contingently. Following extinction, the effects of the competitive NMDA receptor antagonist CGP 39551 (0, 2.5, 5, 10 mg/kg intraperitoneally (i.p.)), two competitive AMPA/kainate antagonists, CNQX (0, 0.75, 1.5, 3 mg/ kg i.p.) and NBQX (0, 1.25, 2.5, 5 mg/kg i.p.), the NMDA/glycine site antagonist L-701,324 (0, 0.63, 1.25, 2.5 mg/kg i.p.), and the mGluR5 antagonist MPEP (0, 1.25, 2.5, 5 mg/kg i.p.) on cue-induced reinstatement of cocaine seeking were examined. The AMPA/kainate receptor antagonists CNQX and NBQX, the NMDA/glycine site antagonist L-701,324, and the mGluR5 antagonist MPEP attenuated significantly cue-induced reinstatement. The NMDA antagonist CGP 39551 failed to affect reinstatement. Additional control experiments indicated that attenuation of cue-induced reinstatement by CNQX, NBQX, L-701,324, and MPEP was not accompanied by significant suppression of spontaneous locomotor activity. These results suggest that conditioned influences on cocaine seeking depend on glutamate transmission. Accordingly, drugs with antagonist properties at various glutamate receptor subtypes could be useful in prevention of relapse induced by conditioned stimuli.

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“…Apart from disrupting the self-administration of ethanol (Stephens and Brown 1999), the AMPA/KA receptor antagonist NBQX also disrupted the expression of behavioral sensitization to amphetamine (Jackson et al 1998;Li et al 1997;Mead and Stephens 1998). A specific role for AMPA receptors in conditioned reinforcement is suggested by findings that DNQX blocked the expression of a cocaine-induced place preference when administered into the NAcc (Kaddis et al 1995) or intracerebroventricularly (Cervo and Samanin 1995).…”

Section: The Effects Of Ampa/ka Receptor Antagonism In the Nucleus Acmentioning

confidence: 99%

Dissociable Effects of Antagonism of NMDA and AMPA/KA Receptors in the Nucleus Accumbens Core and Shell on Cocaine-seeking Behavior

Ciano

Everitt

2001

Neuropsychopharmacology

258

191

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AMPA receptors and motivation for drug: effect of the selective antagonist NBQX on behavioural sensitization and on self-administration in mice

Cited by 39 publications

References 0 publications

Previous Exposure to Psychostimulants Enhances the Reinstatement of Cocaine Seeking by Nucleus Accumbens AMPA

Previous Exposure to Psychostimulants Enhances the Reinstatement of Cocaine Seeking by Nucleus Accumbens AMPA

Ionotropic and Metabotropic Glutamate Receptor Antagonism Attenuates Cue-Induced Cocaine Seeking

Dissociable Effects of Antagonism of NMDA and AMPA/KA Receptors in the Nucleus Accumbens Core and Shell on Cocaine-seeking Behavior

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