Ampa-receptor blockade within the rvlm modulates cardiovascular responses via glutamate during peripheral stimuli

Gray, Terence; Lewis, Eugene R.; Maher, Timothy J.; Ally, Ahmmed

doi:10.1006/phrs.2000.0749

Cited by 10 publications

(1 citation statement)

References 37 publications

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“…In fact, overexpression of other receptor tyrosine kinases (RTKs), or inhibition of neurofibromatosis 1 (NF1) function are also very common in gliomas. They all drive the chronic stimulation of Ras signaling to drive cellular proliferation and migration (Furnari et al, ; Gray, Lewis, Maher, & Ally, ). Other frequent genetic lesions include the loss of phosphatase and tensin homolog ( PTEN ), which antagonizes the phosphatidylinositol‐3 kinase (PI3K) signaling pathway, and activating mutations in PI3KCA , which encodes the p110a catalytic subunit (Furnari et al, ; Gray et al, ; von Deimling, Louis, & Wiestler, ).…”

Section: Introductionmentioning

confidence: 99%

Oncogenic dependence of glioma cells on kish/TMEM167A regulation of vesicular trafficking

Portela

Segura-Collar

Argudo

et al. 2018

Glia

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Genetic lesions in glioblastoma (GB) include constitutive activation of PI3K and EGFR pathways to drive cellular proliferation and tumor malignancy. An RNAi genetic screen, performed in Drosophila melanogaster to discover new modulators of GB development, identified a member of the secretory pathway: kish/TMEM167A. Downregulation of kish/TMEM167A impaired fly and human glioma formation and growth, with no effect on normal glia. Glioma cells increased the number of recycling endosomes, and reduced the number of lysosomes. In addition, EGFR vesicular localization was primed toward recycling in glioma cells. kish/TMEM167A downregulation in gliomas restored endosomal system to a physiological state and altered lysosomal function, fueling EGFR toward degradation by the proteasome. These endosomal effects mirrored the endo/lysosomal response of glioma cells to Brefeldin A (BFA), but not the Golgi disruption and the ER collapse, which are associated with the undesirable toxicity of BFA in other cancers. Our results suggest that glioma growth depends on modifications of the vesicle transport system, reliant on kish/TMEM167A. Noncanonical genes in GB could be a key for future therapeutic strategies targeting EGFR‐dependent gliomas.

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Section: Introductionmentioning

confidence: 99%

Oncogenic dependence of glioma cells on kish/TMEM167A regulation of vesicular trafficking

Portela

Segura-Collar

Argudo

et al. 2018

Glia

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Effects of inducible nitric oxide synthase blockade within the periaqueductal gray on cardiovascular responses during mechanical, heat, and cold nociception

Chaitoff¹,

Toner

Tedesco

et al. 2011

Neurol Sci

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We have examined the role of inducible nitric oxide synthase (iNOS) within the dorsolateral periaqueductal gray mater (dlPAG) on cardiovascular responses during mechanical, thermal, and cold nociception in anesthetized rats. Mechanical stimulus was applied by a unilateral hindpaw pinch for 10 s that increased mean arterial pressure (MAP) and heart rate (HR). Bilateral microdialysis of a selective iNOS inhibitor, aminoguanidine (AGN; 10 μM), into the dlPAG for 30 min augmented MAP and HR responses during a mechanical stimulation. The cardiovascular responses recovered following discontinuation of the drug. Heat stimulus was generated by immersing one hindpaw metatarsus in a water bath at 52°C for 10 s, and this increased MAP and HR. Administration of AGN into the PAG potentiated these cardiovascular responses. Cardiovascular responses recovered following discontinuation of the drug. In contrast, application of a cold stimulus by immersing one hindpaw at 10°C for 10 s resulted in depressor and bradycardic responses. A second cold stimulus resulted in a response that was not significantly different from that prior to or after recovery from the AGN infusion. These results demonstrate that iNOS within the dlPAG plays a differential role in modulating cardiovascular responses during mechanical-, heat-, and cold-mediated nociception.

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Modulation of cardiovascular responses and neurotransmission during peripheral nociception following nNOS antagonism within the periaqueductal gray

Karlsson¹,

Chaitoff²,

Hossain³

et al. 2007

Brain Research

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Ampa-receptor blockade within the rvlm modulates cardiovascular responses via glutamate during peripheral stimuli

Cited by 10 publications

References 37 publications

Oncogenic dependence of glioma cells on kish/TMEM167A regulation of vesicular trafficking

Oncogenic dependence of glioma cells on kish/TMEM167A regulation of vesicular trafficking

Effects of inducible nitric oxide synthase blockade within the periaqueductal gray on cardiovascular responses during mechanical, heat, and cold nociception

Modulation of cardiovascular responses and neurotransmission during peripheral nociception following nNOS antagonism within the periaqueductal gray

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