&amp;nbsp;Telangiectatic osteosarcoma: a review of literature

Liu, Junjian; Liu, Shen; Wang, Jianguang; Zhu, Wenjun; Hua, Yaping; Sun, Wei; Cai, Zhengdong

doi:10.2147/ott.s41351

Cited by 30 publications

(20 citation statements)

References 39 publications

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“…OS, the most common malignant bone tumor that often presents with structural chromosomal alterations, occurs predominantly in adolescents and young adults and accounts for 5% of childhood cancers. 50 , 51 Despite advances in clinical treatments involving surgical resection combined with chemotherapy and/or radiotherapy, 52 , 53 the invasive nature of the disease continues to limit the 5-year survival with OS to merely 20%. Therefore, new, non-conventional treatments using therapeutic targets may help to improve clinical efficacy.…”

Section: Potential Clinical Implications Of Hulcmentioning

confidence: 99%

Current advances of long non-coding RNA highly upregulated in liver cancer in human tumors

Ma¹,

Huang²,

Xu³

et al. 2017

OTT

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Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs (ncRNAs) >200 nucleotides in length that govern diverse biological processes. Recent evidence suggests that lncRNAs are involved in cancer cell proliferation, apoptosis, invasion, migration, and metastasis. Dysregulation of lncRNAs has been observed in various tumors, and lncRNAs act as oncogenes or tumor suppressors in these malignancies. It has been revealed that lncRNA highly upregulated in liver cancer (HULC) is tightly correlated with a number of cancers such as hepatocellular carcinoma, gastric cancer, colorectal cancer, osteosarcoma, and diffuse large B-cell lymphoma. Depletion of HULC suppressed cancer cell proliferation, migration, and invasion and induced apoptosis. Additionally, HULC may function as a diagnostic biomarker and prognostic indicator for some tumors. In this review, we summarize the current knowledge of the role of HULC in cancer progression and the clinical management of human cancers.

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Section: Potential Clinical Implications Of Hulcmentioning

confidence: 99%

Current advances of long non-coding RNA highly upregulated in liver cancer in human tumors

Ma¹,

Huang²,

Xu³

et al. 2017

OTT

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“…The differential diagnosis of MGCTB should also include telangiectatic osteosarcoma (TO) and giant cell-rich osteosarcoma (GCRO), both of which present at a younger patient age than MGCTB. [ 10 , 11 ] Currently, no published studies have described the imaging features of GCRO in the spine. GCRO in the long bone usually presents as expansile, eccentric, and osteolytic lesions, and sometimes a soft tissue mass and periosteal reaction are observed.…”

Section: Discussionmentioning

confidence: 99%

“…The imaging findings of TO are an osteolytic, destructive tumor with limited or no matrix mineralization or periosteal new bone formation, usually with multiple and small fluid–fluid levels. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

Primary malignancy in giant cell tumor of thoracic vertebrae

Shi

Peng

et al. 2018

Medicine

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Rationale:Primary malignancy in giant cell tumor of bone (PMGCTB) is extremely unusual. PMGCTB in the thoracic vertebrae is particularly rare.Patients concerns:A 23-year-old man was admitted with a chief complaint of chest pain associated with cough for approximately 3 days. Physical examination revealed a palpable, immobile, tender, 7 cm mass in the right paravertebral area of the thoracolumbar spine.Diagnosis:Computed tomography images revealed an osteolytic, expansive, and eccentric lesion on the vertebral bodies and right accessory processes with spinal cord compression in the thoracic vertebra, with right rib also having bone destruction. Magnetic resonance imaging revealed multiple fluid–fluid levels occupying more than one-third of the lesions. On the basis of the imaging and pathological findings, the final pathological diagnosis was PMGCTB with aneurysmal bone cyst.Interventions:The patient underwent successful wide spondylectomy of T9/10 to remove the tumor, and adjuvant chemotherapy based on the protocol used for osteosarcoma.Outcomes:After 4 years of follow-up, there is no clinical or radiological evidence of recurrence.Lessons:PMGCTB is difficult to distinguish from giant cell tumor of bone. PMGCTB should be considered when lesions appear with multiple fluid–fluid levels and soft tissue mass.

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“…Telangiectatic OS has overall low cellularity and sparse osteoid production. Interrupted periosteal reaction and detection of bone matrix are helpful in establishing the correct diagnosis of telangiectatic OS 2615. Minimal osteoid in small cell OS makes its radiology atypical.…”

Section: Diagnostic Dilemmas Of Osteosarcomamentioning

confidence: 99%

Osteosarcoma: Diagnostic dilemmas in histopathology and prognostic factors

Wadhwa

2014

IJOO

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Osteosarcoma (OS), the commonest malignancy of osteoarticular origin, is a very aggressive neoplasm. Divergent histologic differentiation is common in OS; hence triple diagnostic approach is essential in all cases. 20% cases are atypical owing to lack of concurrence among clinicoradiologic and pathologic features necessitating resampling. Recognition of specific anatomic and histologic variants is essential in view of better outcome. Traditional prognostic factors of OS do stratify patients for short term outcome, but often fail to predict their long term outcome. Considering the negligible improvement in the patient outcome during the last 20 years, search for novel prognostic factors is in progress like ezrin vascular endothelial growth factor, chemokine receptors, dysregulation of various micro ribonucleic acid are potentially promising. Their utility needs to be validated by long term followup studies before they are incorporated in routine clinical practice.

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Telangiectatic osteosarcoma: a review of literature

Cited by 30 publications

References 39 publications

Current advances of long non-coding RNA highly upregulated in liver cancer in human tumors

Current advances of long non-coding RNA highly upregulated in liver cancer in human tumors

Primary malignancy in giant cell tumor of thoracic vertebrae

Osteosarcoma: Diagnostic dilemmas in histopathology and prognostic factors

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