&amp;nbsp;Neurodegenerative Multioethiology Lou Gehrig&amp;rsquo;s Disease &amp;ndash; Genetic Mutations, Pharmacological Mechanisms and Applications of Rilusole

Tsvetkova, Dobrina; Ivanova, Stefka; Obreshkova, Danka

doi:10.51847/w9frjsnxjp

Int J Pharm Res Allied Sci

2023

DOI: 10.51847/w9frjsnxjp

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 Neurodegenerative Multioethiology Lou Gehrig’s Disease – Genetic Mutations, Pharmacological Mechanisms and Applications of Rilusole

Dobrina Tsvetkova,

Stefka Ivanova,

Danka Obreshkova

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2024

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Reconsidering red blood cells as the diagnostic potential for neurodegenerative disorders

Yadav,

Deepika,

Moar

et al. 2024

Biology of the Cell

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BackgroundRed blood cells (RBCs) are usually considered simple cells and transporters of gases to tissues.HypothesisHowever, recent research has suggested that RBCs may have diagnostic potential in major neurodegenerative disorders (NDDs).ResultsThis review summarizes the current knowledge on changes in RBC in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and other NDDs. It discusses the deposition of neuronal proteins like amyloid‐β, tau, and α‐synuclein, polyamines, changes in the proteins of RBCs like band‐3, membrane transporter proteins, heat shock proteins, oxidative stress biomarkers, and altered metabolic pathways in RBCs during neurodegeneration. It also highlights the comparison of RBC diagnostic markers to other in‐market diagnoses and discusses the challenges in utilizing RBCs as diagnostic tools, such as the need for standardized protocols and further validation studies.Significance statementThe evidence suggests that RBCs have diagnostic potential in neurodegenerative disorders, and this study can pave the foundation for further research which may lead to the development of novel diagnostic approaches and treatments.

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Reconsidering red blood cells as the diagnostic potential for neurodegenerative disorders

Yadav,

Deepika,

Moar

et al. 2024

Biology of the Cell

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show abstract

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Neurodegenerative Multioethiology Lou Gehrig’s Disease – Genetic Mutations, Pharmacological Mechanisms and Applications of Rilusole

Cited by 1 publication

References 85 publications

Reconsidering red blood cells as the diagnostic potential for neurodegenerative disorders

Reconsidering red blood cells as the diagnostic potential for neurodegenerative disorders

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