&amp;lt;i&amp;gt;Salmonella typhimurium&amp;lt;/i&amp;gt;—A threat for a newborn

Maroszyńska, Iwona; Fortecka-Piestrzeniewicz, Katarzyna; Niedźwiecka, Marta

doi:10.4236/ojog.2013.38113

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…There have been numerous reports related to the emergence of antibiotic resistance in Salmonella Typhimurium [ 19 , 20 ], and the presence of genes enabling it to multiply in macrophages and use, for example, iron [ 7 ]. Following reports of Salmonella occurring in newborns as a zoonosis [ 21 ], the aim of the present study was to provide a detailed phenotypic and genotypic analysis of Salmonella Typhimurium isolated from human milk and determine its potential for invasiveness, pathogenicity, and antibiotic resistance using whole-genome sequencing.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Phenotype and Genotype Virulence and Antimicrobial Factors of Salmonella Typhimurium Isolated from Human Milk

Pławińska-Czarnak

Wódz²,

Guzowska

et al. 2023

IJMS

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Salmonella is a common foodborne infection. Many serovars belonging to Salmonella enterica subsp. enterica are present in the gut of various animal species. They can cause infection in human infants via breast milk or cross-contamination with powdered milk. In the present study, Salmonella BO was isolated from human milk in accordance with ISO 6579-1:2017 standards and sequenced using whole-genome sequencing (WGS), followed by serosequencing and genotyping. The results also allowed its pathogenicity to be predicted. The WGS results were compared with the bacterial phenotype. The isolated strain was found to be Salmonella enterica subsp. enterica serovar Typhimurium 4:i:1,2_69M (S. Typhimurium 69M); it showed a very close similarity to S. enterica subsp. enterica serovar Typhimurium LT2. Bioinformatics sequence analysis detected eleven SPIs (SPI-1, SPI-2, SPI-3, SPI-4, SPI-5, SPI-9, SPI-12, SPI-13, SPI-14, C63PI, CS54_island). Significant changes in gene sequences were noted, causing frameshift mutations in yeiG, rfbP, fumA, yeaL, ybeU (insertion) and lpfD, avrA, ratB, yacH (deletion). The sequences of several proteins were significantly different from those coded in the reference genome; their three-dimensional structure was predicted and compared with reference proteins. Our findings indicate the presence of a number of antimicrobial resistance genes that do not directly imply an antibiotic resistance phenotype.

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Section: Introductionmentioning

confidence: 99%

Comparison of Phenotype and Genotype Virulence and Antimicrobial Factors of Salmonella Typhimurium Isolated from Human Milk

Pławińska-Czarnak

Wódz²,

Guzowska

et al. 2023

IJMS

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Infection néonatale tardive à Salmonella typhimurium productrice de bêtalactamase à spectre élargi (à propos de cinq cas)

et al. 2021

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L’infection néonatale secondaire à Salmonella typhimurium est rare et peut revêtir des aspects cliniques variables pouvant aller jusqu’au sepsis grave souvent mortel. L’objectif de ce travail est d’étudier les aspects cliniques, bactériologiques et évolutifs de l’infection néonatale à S. typhimurium productrice de bêtalactamases à spectre élargi (BLASE+), au moyen d’une étude rétrospective sur une durée de trois ans incluant cinq observations. Tous les cas étaient en provenance du même hôpital provincial. L’âge moyen était de 16 jours. La symptomatologie principale était liée à un tableau de déshydratation aiguë. Le bilan bactériologique a objectivé un S. typhimurium BLSE+ chez tous les cas. La prise en charge thérapeutique a reposé sur une antibiothérapie adaptée à l’antibiogramme, associée à un traitement symptomatique. L’évolution fut favorable dans quatre cas et fatale pour un seul patient en raison d’un sepsis extrêmement sévère. Bien que les céphalosporines de troisième génération soient le traitement de référence, l’émergence de souches de plus en plus résistantes rend indispensable l’adaptation de l’antibiothérapie à l’antibiogramme du germe isolé.

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<i>Salmonella typhimurium</i>—A threat for a newborn

Abstract: ABSTRACT

Cited by 2 publications

References 6 publications

Comparison of Phenotype and Genotype Virulence and Antimicrobial Factors of Salmonella Typhimurium Isolated from Human Milk

Comparison of Phenotype and Genotype Virulence and Antimicrobial Factors of Salmonella Typhimurium Isolated from Human Milk

Infection néonatale tardive à Salmonella typhimurium productrice de bêtalactamase à spectre élargi (à propos de cinq cas)

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