&amp;lt;i&amp;gt;In vivo&amp;lt;/i&amp;gt; Distribution of Inorganic Nanoparticles in Preclinical Models

Varna, Mariana; Ratajczak, Philippe; Ferreira, I.; Lebœuf, Christophe; Bousquet, Guilhem; Janin, Anne

doi:10.4236/jbnb.2012.322033

Cited by 48 publications

(33 citation statements)

References 107 publications

(127 reference statements)

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“…Typically, nanoparticles will accumulate in certain tissues and organs, in the same way it happens with animals (Varna et al, 2012). As commented above, plant organs acting as strong sinks for sap and nutrients are likely to accumulate nanomaterials traveling through the vascular system, mainly fruits (Servin et al, 2013), grains (Lin et al, 2009), flowers, and young leaves (Cifuentes et al, 2010;Koo et al, 2015).…”

Section: Movement Of Nanoparticles Inside Plantsmentioning

confidence: 96%

Interaction of Nanomaterials with Plants: What Do We Need for Real Applications in Agriculture?

Pérez‐de‐Luque

2017

Front. Environ. Sci.

381

166

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The number of published researching works related with applications of nanomaterials in agriculture is increasing every year. Most of such works focus on the synthesis of nanodevices, their characteristics as nanocarriers for controlled release of active substances, and their interaction (either positive or negative) with plants or microorganisms under controlled conditions. Important knowledge has been gained about the uptake and distribution of nanomaterials in plants, although there are still gaps regarding internalization inside plant cells. Nanoparticle traits and plant species greatly affect the interaction, and nanodevices can enter and move through different pathways (apoplast vs. symplast), what influences their effectiveness and their final fate. Depending on the effect we are expecting for a nanocarrier, the application method might be critical. However, in order to get that research used in the field, some problems must be addressed. First, the cost for escalating the production of nanodevices must be affordable with the current production cost of agricultural goods. Second, we need to be sure that a technology is safe before spreading it into the environment. Third, consumers will distrust a technology unfamiliar for them in the same way that happened with transgenic crops. We need to broaden our horizons and start looking for real practical approaches, filling the main gaps that hamper our jump from laboratory research into field applications.

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Section: Movement Of Nanoparticles Inside Plantsmentioning

confidence: 96%

Interaction of Nanomaterials with Plants: What Do We Need for Real Applications in Agriculture?

Pérez‐de‐Luque

2017

Front. Environ. Sci.

381

166

View full text Add to dashboard Cite

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“…The choice of the incubation period reflects the fact that the uptake was relatively rapid and had already occurred after 2 h; therefore, toxicity would be expected to be observed within 24 h. 45 In addition, the doses of tested DNPs were chosen as similar to those resulting in good tolerance when injected intravenously in nude mice. 46,47 The results showed no differences in cell death in treated cells compared with untreated control cells. Cell viability was also analyzed by light microscopy after 48 h of incubation of A20 cells in the presence of DNPs, and no effects on cell morphology were observed (Insets 1 and 2, Figure 7B).…”

Section: Cell Viabilitymentioning

confidence: 88%

Nanoparticle-based strategy for personalized B-cell lymphoma therapy

Martucci¹,

Migliaccio²,

Ruggiero³

et al. 2016

IJN

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B-cell lymphoma is associated with incomplete response to treatment, and the development of effective strategies targeting this disease remains challenging. A new personalized B-cell lymphoma therapy, based on a site-specific receptor-mediated drug delivery system, was developed in this study. Specifically, natural silica-based nanoparticles (diatomite) were modified to actively target the antiapoptotic factor B-cell lymphoma/leukemia 2 (Bcl2) with small interfering RNA (siRNA). An idiotype-specific peptide (Id-peptide) specifically recognized by the hypervariable region of surface immunoglobulin B-cell receptor was exploited as a homing device to ensure specific targeting of lymphoma cells. Specific nanoparticle uptake, driven by the Id-peptide, was evaluated by flow cytometry and confocal microscopy and was increased by approximately threefold in target cells compared with nonspecific myeloma cells and when a random control peptide was used instead of Id-peptide. The specific internalization efficiency was increased by fourfold when siRNA was also added to the modified nanoparticles. The modified diatomite particles were not cytotoxic and their effectiveness in downregulation of gene expression was explored using siRNA targeting Bcl2 and evaluated by quantitative real-time polymerase chain reaction and Western blot analyses. The resulting gene silencing observed is of significant biological importance and opens new possibilities for the personalized treatment of lymphomas

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“…Especially size by the inverse relationship with surface area can increase the reactivity of a material with the target that comes in contact. The so called "size effects" as surface reactivity play key role for the bio-distribution, cellular uptake, internalization and activation of intracellular toxicity factors and signals and also other bio-interactions influencing cytotoxicity [3][4][5] biocompatibility and bio-functionality. Electrochemical technique has been considered as the best candidate for the on-site detection of molecules such DNA due to the high sensitivity, simplicity, reproducibility, low cost, relatively short analysis time and direct analysis, without any extraction, clean-up or preconcentration steps, and easy to miniaturization [6].…”

Section: Introductionmentioning

confidence: 99%

Application of promising carbonaceous materials in electrochemical DNA sensing

Karastogianni¹,

Deliyanni²,

Girousi³

2017

J Appl Bioanal

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The data reported in literature demonstrate that carbon paste electrodes (CPEs) are very suitable for a variety of applications and many works have thus been devoted in the development of new sensitive and selective electrode surfaces based on carbon paste as the electrode material of choice. The application of novel and promising carbonaceous materials, as electrode surfaces, is an issue of great concern. In this work the experimental results of the characterization and comparison of electrode surfaces based on alternatively prepared carbonaceous materials (activated carbon (B), HNO 3 oxidized activated carbon (B5), Ag impregnated activated carbon (B-Ag) and graphite oxide (GO), are being demonstrated. Scaning Electron Microscopy SEM), surface acidity, FTIR spectroscopy, XRD diffractometry and electrochemical techniques (cyclic voltammetry, differential pulse voltammetry) were applied in the characterization of novel carbonaceous materials aimed at electrochemical DNA sensing.

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<i>In vivo</i> Distribution of Inorganic Nanoparticles in Preclinical Models

Cited by 48 publications

References 107 publications

Interaction of Nanomaterials with Plants: What Do We Need for Real Applications in Agriculture?

Interaction of Nanomaterials with Plants: What Do We Need for Real Applications in Agriculture?

Nanoparticle-based strategy for personalized B-cell lymphoma therapy

Application of promising carbonaceous materials in electrochemical DNA sensing

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