&amp;lt;i&amp;gt;Antihypertensive and antioxidant capacity of a high protein beverage (walnut-sesame seeds- oat-soybean)&amp;lt;/i&amp;gt;

Mares-Mares, Everardo; Aguilar-Bravo, Clara; Herrera-Castillo, Fatima Luz Maria; Sosa-Morales, M.; Rincón-Castro, Ma. Cristina Del; León-Galván, Ma. Fabiola

doi:10.13031/aim.201701383

Cited by 2 publications

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“…However, recent research efforts have linked the antioxidant activity of canary seeds to the release of hydrophobic peptides from prolamin proteins during gastrointestinal digestion [6,7]. In accordance with these findings, various studies have also shown that protein hydrolysis is associated with a rise in antioxidant properties [8][9][10][11]. Moreover, it has been shown that a peptides' rise in antioxidant activity is dependent on their amino acid composition, structure, hydrophobicity, and position in the peptide sequence [12].…”

Section: Introductionmentioning

confidence: 83%

Oxidative Stress Protection by Canary Seed (Phalaris canariensis L.) Peptides in Caco-2 Cells and Caenorhabditis elegans

et al. 2022

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During oxidative stress, degenerative diseases such as atherosclerosis, Alzheimer’s, and certain cancers are likely to develop. Recent research on canary seed (Phalaris canariensis) peptides has demonstrated the high in vitro antioxidant potential. Thus, this study aimed to assess the cellular and in vivo antioxidant capacity of a low-molecular-weight (<3 kDa) canary seed peptide fraction (CSPF) using Caco-2 cells and the Caenorhabditis elegans model. The results show that the CSPF had no cytotoxicity effect on Caco-2 cells at any tested concentration (0.3–2.5 mg/mL). Additionally, the cellular antioxidant activity (CAA) of the CSPF was concentration-dependent, and the highest activity achieved was 80% by the CSPF at 2.5 mg/mL. Similarly, incubation with the CSPF significantly mitigated the acute and chronic oxidative damage, extending the lifespan of the nematodes by 88 and 61%, respectively. Furthermore, it was demonstrated that the CSPF reduced the accumulation of reactive oxygen species (ROS) to safe levels after sub-lethal doses of pro-oxidant paraquat. Quantitative real-time PCR revealed that the CSPF increased the expression of oxidative-stress-response-related gene GST-4. Overall, these results show that the CSPFs relied on GST-4 upregulation and scavenging of free radicals to confer oxidative stress protection and suggest that a CSPF can be used as a natural antioxidant in foods for health applications.

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Section: Introductionmentioning

confidence: 83%

Oxidative Stress Protection by Canary Seed (Phalaris canariensis L.) Peptides in Caco-2 Cells and Caenorhabditis elegans

et al. 2022

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Bioactive Peptides and Dietary Polyphenols: Two Sides of the Same Coin

et al. 2020

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The call for health-promoting nutraceuticals and functional foods containing bioactive compounds is growing. Among the great diversity of functional phytochemicals, polyphenols and, more recently, bioactive peptides have stood out as functional compounds. The amount of an ingested nutrient able to reach the bloodstream and exert the biological activity is a critical factor, and is affected by several factors, such as food components and food processing. This can lead to unclaimed interactions and/or reactions between bioactive compounds, which is particularly important for these bioactive compounds, since some polyphenols are widely known for their ability to interact and/or precipitate proteins/peptides. This review focuses on this important topic, addressing how these interactions could affect molecules digestion, absorption, metabolism and (biological)function. At the end, it is evidenced that further research is needed to understand the true effect of polyphenol-bioactive peptide interactions on overall health outcomes.

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<i>Antihypertensive and antioxidant capacity of a high protein beverage (walnut-sesame seeds- oat-soybean)</i>

Cited by 2 publications

References 0 publications

Oxidative Stress Protection by Canary Seed (Phalaris canariensis L.) Peptides in Caco-2 Cells and Caenorhabditis elegans

Oxidative Stress Protection by Canary Seed (Phalaris canariensis L.) Peptides in Caco-2 Cells and Caenorhabditis elegans

Bioactive Peptides and Dietary Polyphenols: Two Sides of the Same Coin

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