&amp;lt;i&amp;gt;ADRB2&amp;lt;/i&amp;gt;, &amp;lt;i&amp;gt;ADRB3&amp;lt;/i&amp;gt;, &amp;lt;i&amp;gt;BDKRB2&amp;lt;/i&amp;gt; and &amp;lt;i&amp;gt;MTNR1B&amp;lt;/i&amp;gt; Genes Related to Body fat Modulation and Its Interaction with Physical Activity and Blood Pressure

Marcadenti, Aline

doi:10.4236/ojemd.2015.57012

Cited by 5 publications

(4 citation statements)

References 57 publications

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“…In the current study, we found SNPs significantly associated with IMF in a haplotype block spanning 36 kb on SSC 7, which contains only one known gene, BDKRB2 (bradykinin receptor B2). BDKRB2 is a protein coding gene that is normally highly expressed in muscles, such as smooth muscle (Marcadenti, 2015). Bradykinin is an inflammatory mediator with vasodilation activity and exerts its effects via two receptor subtypes (the B1 and B2 receptors) (Saunders et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Single-Locus and Multi-Locus Genome-Wide Association Studies for Intramuscular Fat in Duroc Pigs

et al. 2019

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Intramuscular fat (IMF) is an important quantitative trait of meat, which affects the associated sensory properties and nutritional value of pork. To gain a better understanding of the genetic determinants of IMF, we used a composite strategy, including single-locus and multi-locus association analyses to perform genome-wide association studies (GWAS) for IMF in 1,490 Duroc boars. We estimated the genomic heritability of IMF to be 0.23 ± 0.04. A total of 30 single nucleotide polymorphisms (SNPs) were found to be significantly associated with IMF. The single-locus mixed linear model (MLM) and multiple-locus methods multi-locus random-SNP-effect mixed linear model (mrMLM), fast multi-locus random-SNP-effect efficient mixed model association (FASTmrEMMA), and integrative sure independence screening expectation maximization Bayesian least absolute shrinkage and selection operator model (ISIS EM-BLASSO) analyses identified 5, 9, 8, and 21 significant SNPs, respectively. Interestingly, a novel quantitative trait locus (QTL) on SSC 7 was found to affect IMF. In addition, 10 candidate genes ( BDKRB2 , GTF2IRD1 , UTRN , TMEM138 , DPYD , CASQ2 , ZNF518B , S1PR1 , GPC6 , and GLI1 ) were found to be associated with IMF based on their potential functional roles in IMF. GO analysis showed that most of the genes were involved in muscle and organ development. A significantly enriched KEGG pathway, the sphingolipid signaling pathway, was reported to be associated with fat deposition and obesity. Identification of novel variants and functional genes will advance our understanding of the genetic mechanisms of IMF and provide specific opportunities for marker-assisted or genomic selection in pigs. In general, such a composite single-locus and multi-locus strategy for GWAS may be useful for understanding the genetic architecture of economic traits in livestock.

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Section: Discussionmentioning

confidence: 99%

Single-Locus and Multi-Locus Genome-Wide Association Studies for Intramuscular Fat in Duroc Pigs

et al. 2019

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“…BMI and obesity have long been known as risk factors for DVT 27 , 28 . On the other hand, although no evidence has been published to establish a direct connection between BDKRB2 and obesity or BMI, BDKRB2 was reported to be significantly associated with other human metabolism-related traits, including body fat modulation 29 and diabetes 30 . In addition, interaction effects have also been identified between the SNPs of BDKRB2 and physical activity and blood pressure 29 .…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, although no evidence has been published to establish a direct connection between BDKRB2 and obesity or BMI, BDKRB2 was reported to be significantly associated with other human metabolism-related traits, including body fat modulation 29 and diabetes 30 . In addition, interaction effects have also been identified between the SNPs of BDKRB2 and physical activity and blood pressure 29 . These previous findings indicated that the effect between rs2069588 and BMI might also be mediated by some other underlying factors in our study.…”

Section: Discussionmentioning

confidence: 99%

Genetic effects of BDKRB2 and KNG1 on deep venous thrombosis after orthopedic surgery and the potential mediator

Wang

Cheng

Wang

et al. 2018

Sci Rep

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Deep venous thrombosis (DVT) is a common complication of orthopedic surgery. Genetic risk factors and high heritability carried a substantial risk of DVT. In this study, we aimed to investigate the potential association in the Han Chinese population between the polymorphisms of BDKRB2 and KNG1 and DVT after orthopedic surgery (DVTAOS). A total of 3,010 study subjects comprising 892 DVT cases and 2,118 controls were included in the study, and 39 single nucleotide polymorphisms (SNPs) in total (30 for BDKRB2 and 9 for KNG1) were chosen for genotyping. Two SNPs, rs710446 (OR = 1.27, P = 0.00016) and rs2069588 (OR = 1.29, P = 0.00056), were identified as significantly associated with DVTAOS. After adjusting for BMI, the significance of rs2069588 decreased (P = 0.0013). Haplotype analyses showed that an LD block containing rs2069588 significantly correlated with the DVTAOS risk. Moreover, bioinformatics analysis indicated that hsa-miR-758-5p and BDKRB2 formed miRNA/SNP target duplexes if the rs2069588 allele was in the T form, suggesting that rs2069588 may alter BDKRB2 expression by affecting hsa-miR-758-5p/single-nucleotide polymorphism target duplexes. Our results demonstrate additional evidence supporting that there is an important role for the KNG1 and BDKRB2 genes in the increased susceptibility of DVTAOS.

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“…Specially, we highlighted the gene bradykinin receptor B2 ( BDKRB2 ) as a strong candidate for IMF according to its functions, as our previous study reported (Ding et al ., 2019). BDKRB2 plays a crucial role in muscle and adipose tissues and the overexpression of the bradykinin receptor 2 gene has shown a potential link between excessive secretion of proinflammatory cytokines and excessive expansion of adipose tissue (Hajer et al ., 2008; Eder et al ., 2009; Marcadenti, 2015). Another gene in this region, autophagy‐related 2B ( ATG2B ), has not been previously described as related to IMF in Duroc pigs.…”

Section: Figurementioning

confidence: 99%

A large‐scale genome‐wide association analysis reveals QTL and candidate genes for intramuscular fat content in Duroc pigs

et al. 2021

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Summary This study aimed at identifying genomic regions and genes associated with intramuscular fat content (IMF) in Duroc pigs using a weighted single‐step GWAS. Data from 3912 pigs, of which 3770 animals were genotyped with GeneSeek Porcine 50K Bead chip, were used for the association analysis. We identified 19 genomic regions that each explained >1% of the additive genetic variance associated with IMF. Notably, a consistent QTL on SSC7 (117.42–117.92 Mb) was confirmed, explaining 3.70% of the additive genetic variance, and two genes, BDKRB2 and ATG2B, were highlighted as promising candidates for IMF. Two QTL (SSC7, 94.19–94.64 Mb; SSC14, 123.25–123.75 Mb), which harbored MED6 and MAP3K9 genes and TCF7L2 gene respectively, were newly identified as associated with IMF. In conclusion, we identified a consistent QTL and additional genomic regions and genes that contributed to the genetic variance of IMF using a large‐scale sample size of genotyped pigs and genealogical information.

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<i>ADRB2</i>, <i>ADRB3</i>, <i>BDKRB2</i> and <i>MTNR1B</i> Genes Related to Body fat Modulation and Its Interaction with Physical Activity and Blood Pressure

Cited by 5 publications

References 57 publications

Single-Locus and Multi-Locus Genome-Wide Association Studies for Intramuscular Fat in Duroc Pigs

Single-Locus and Multi-Locus Genome-Wide Association Studies for Intramuscular Fat in Duroc Pigs

Genetic effects of BDKRB2 and KNG1 on deep venous thrombosis after orthopedic surgery and the potential mediator

A large‐scale genome‐wide association analysis reveals QTL and candidate genes for intramuscular fat content in Duroc pigs

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