2000
DOI: 10.1006/bbrc.2000.3417
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AMP-Activated Protein Kinase Is Activated by the Stimulations of Gq-Coupled Receptors

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Cited by 66 publications
(47 citation statements)
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“…A previous report showed that plasma membrane receptors coupled to the phosphoinositide signal transduction system through the G-proteins Gq and G11 activate AMPK [60]. More specifically, stimulation of Gq/11-coupled muscarinic receptors by carbachol was shown to activate AMPK in rat parotid acinar cells [40].…”
Section: Discussionmentioning
confidence: 95%
“…A previous report showed that plasma membrane receptors coupled to the phosphoinositide signal transduction system through the G-proteins Gq and G11 activate AMPK [60]. More specifically, stimulation of Gq/11-coupled muscarinic receptors by carbachol was shown to activate AMPK in rat parotid acinar cells [40].…”
Section: Discussionmentioning
confidence: 95%
“…we and other groups previously reported that stimulation of gαqPcrs activated amPK using an in vitro kinase assay with the anti-amPK antibody and a synthetic peptide substrate for amPK [36][37][38]. in this report, we investigated activation of amPK by immunoblot using anti phospho-amPK antibodies.…”
Section: Rt-pcrmentioning
confidence: 89%
“…Furthermore, we and other groups reported that activation of gαqPcr induced amPK activity [36][37][38]. Thus, we proposed that glucose transported by insulin or gαq activation has a distinct destination in cells; glucose transported into cells after gαq activation is immediately metabolized and consumed as an availability of cellular energy as well as aTP which the gαq-induced amPK activation supplied through activation of aTP-generating pathways and the decrease of aTP expenditure by suppressing macromolecule synthesis [39].…”
mentioning
confidence: 94%
“…Materials-Phentolamine, propranolol, and isoproterenol were purchased from Sigma, AKT inhibitor (10-DEBC) was purchased from Tocris USA, and PKA inhibitor (PKA-I, [14][15][16][17][18][19][20][21][22] was purchased from Calbiochem.…”
Section: Methodsmentioning
confidence: 99%
“…The effects of leptin through the hypothalamus on muscle AMPK involve ␣-adrenergic receptors in muscle (8). The ␣-adrenergic agonist, phenylephrine, activates AMPK in isolated soleus muscle, C2C12 myocytes, and CHO cells (8,14,15), whereas the ␤-adrenergic agonist, isoproterenol, stimulates AMPK in isolated adipocytes (16). Norepinephrine and epinephrine, both dual ␣ and ␤ agonists, activate AMPK in brown adipocytes in vitro (17) and white adipocytes ex vivo (18), and in the latter, activation of AMPK was necessary for maximal activation of lipolysis (18).…”
mentioning
confidence: 99%