AMP‐activated protein kinase is a key regulator of obesity‐associated factors

Abstract

An imbalance between caloric intake and energy expenditure leads to obesity.Obesity is an important risk factor for the development of several metabolic diseases including insulin resistance, metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease. So, controlling obesity could be effective in the improvement of obesity-related diseases. Various factors are involved in obesity, such as AMP-activated protein kinases (AMPK), silent information regulators, inflammatory mediators, oxidative stress parameters, gastrointestinal hormones, adipokines, angiopoietin-like proteins, and microRNAs. These factors play an important role in obesity by controlling fat metabolism, energy homeostasis, food intake, and insulin sensitivity. AMPK is a heterotrimeric serine/threonine protein kinase known as a fuel-sensing enzyme. The central role of AMPK in obesity makes it an attractive molecule to target obesity and related metabolic diseases. In this review, the critical

From Kinases to Diseases: Investigating the Role of AMPK in Human Pathologies

“…In 2019, it was estimated that 463 million individuals were living with diabetes worldwide [92]. The relationship between diabetes development and AMPK dysregulation further highlights the significance of AMPK in maintaining proper glucose metabolism [93]. In this regard, type 2 diabetes, formerly known as noninsulin-dependent diabetes mellitus or adult-onset diabetes, is a metabolic disorder characterized by dysregulated glucose levels in the blood and abnormal metabolism of lipids.…”