Amoxicillin encapsulated in the N-2-hydroxypropyl trimethyl ammonium chloride chitosan and N,O-carboxymethyl chitosan nanoparticles: Preparation, characterization, and antibacterial activity

Zhao, Zhi; Han, Jianming; Xu, Shangen; Jin, Zheng; Yin, Tan Hui; Zhao, Kai

doi:10.1016/j.ijbiomac.2022.09.035

Cited by 10 publications

(6 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A sustained release of amoxicillin was reported with a good cytocompatibility profile. 97 N,O-Carboxymethyl CS and modified CSbased NPs were also developed for vaccine delivery. The intramuscular administration of the prepared NPs resulted in higher immunoglobulin production in mice.…”

Section: Chitosan Derivative-based Nanocarriersmentioning

confidence: 99%

See 1 more Smart Citation

Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications

Manna

Seth

Gupta

et al. 2023

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Over the past few decades, chitosan (CS) has gained the attention of researchers investigating newer biomaterial-based carriers for drugs in pharmaceutical and biomedical research. Combined with its nontoxic behavior, biodegradability, and biocompatibility, chitosan has found widespread applications in the fields of drug delivery, tissue engineering, and cosmetics. As a novel drug carrier, chitosan is regarded as one of the promising biomaterials in the pharmaceutical industry. The extensive use of this cationic biopolysaccharide in the delivery of therapeutic agents has brought a few limitations of chitosan into the limelight. Various chemical modifications of chitosan can minimize these limitations and improve the efficacy of chitosan as a drug carrier. The effectiveness of several chemically modified chitosan derivatives, including trimethyl chitosan, thiolated chitosan, PEGylated chitosan, and other chitosan derivatives, has been investigated by many researchers for the controlled and target specific delivery of therapeutics. The chemically modified chitosan derivatives exhibited greater importance in the current scenario on drug delivery due to their solubility in wide range of media along with their interaction with pharmaceutically active ingredients. Chitosan derivatives have also attracted attention in several biomedical fields, including wound healing, hyperthermia therapy, tissue engineering, and bioadhesives. The present review narrates the sources and common physicochemical properties of chitosan, including several important synthetic modifications to obtain chemically modified chitosans and their applications in targetspecific drug delivery, along with several biomedical applications.

show abstract

Section: Chitosan Derivative-based Nanocarriersmentioning

confidence: 99%

“…The study results confirmed the successful encapsulation of the drug into the nanoparticulate core and the retention of its antibacterial efficacy. A sustained release of amoxicillin was reported with a good cytocompatibility profile …”

Section: Chitosan Derivative-based Nanocarriersmentioning

confidence: 99%

Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications

Manna

Seth

Gupta

et al. 2023

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

“…The peak at 3437.08 cm-1 in the FTIR spectrum of GNPs is attributable to the SPR, the metal nanoparticles since the falling light matches the natural frequency of electrons in the model (GNPs), the resonance effect that enhances the electric field and results in a strong absorption of light (Novikov et al, 2012). Since (Selvakannan & Sastry, 2004) indicates that the FTIR spectrum analysis of GNPs covered by citrate has a peak at 3,428 cm-1, this peak is for vibrating the stretching of the hydroxyl group (-OH), which is present on the surface of the nanoparticles causes adsorption of citrate particles, and (Zhao et al,2013) also indicated the appearance of a peak at 3430 cm-1 for nanoparticles of gold that belong to the stretch vibration peak of -OH as in Figure 9. Figure 10 shows the presence of a peak for the group of -OH at 3435 cm-1 that attributed to the stretching peak of the hydroxyl group in flavonoid molecules, which agrees with the finding of (Singh et al, 2016), which indicated that due to the expansion peak of -OH in the quercetin (type of flavonoid) loaded on the GNPs.…”

Section: -Fourier-transform Infrared Spectroscopy-ftirmentioning

confidence: 99%

Anti-Giardia Activity of Gold Nanoparticle and Flavonoid-Loaded Gold Nanoparticles

Al-Badry,

Al-Samarrai,

Mohammed

2023

Egyptian Academic Journal of Biological Sciences, B. Zoology

View full text Add to dashboard Cite

The study includes the preparation of gold nanoparticles-GNPs by chemical synthesis and loading of isolated flavonoids from Cymbopogon citratus on GNPs. For GNPs and flavonoids-loaded-GNPs characterization, transmission electron microscopy-TEM, ultravioletvisible(UV) spectroscopy and Fourier-transform infrared spectroscopy are employed.Twenty-five adult male rabbits were used, divided into five main groups (5 rabbits in each group): Negative control group(C-) orally treated with drinking water only, Positive control(C+) orally treated with parasite cysts (4×10 3 cysts /ml) to induce Giardiasis, the first group(G1): treated with 30mg/kg/day of metronidazole after inducing Giardiasis, while the second group(G2): treated with100mg/Kg/day of GNPs after inducing Giardiasis, and third group (G3): treated with 50 mg/Kg/day of flavonoidsloaded GNPs after inducing Giardiasis.The result of TEM analysis showed that the mean size of the isolated flavonoids was 433 nm, irregularly spherical, and the mean of GNPs was 14.1 nm and the shape of the particles was spherical, While the mean size of flavonoid-loaded-GNPs was 17 nm, and the particle shape was spherical.The treatment response showed that the treatment response with metronidazole(in G1) was lower than the treatment with the GNPs(in G2) and flavonoids-loaded GNPs (in G3). The C+ indicates an increase in the cysts number in the 1 st ,2 nd and 3 rd days after inducing infection with the parasite, and then the number of cysts gradually decreased on the 4th day after the infection to the lowest value on the 10th day. The treatment response for GNPs(G2) was on the 3 rd day, while in G3 the treatment response appeared on the second day. From the results of this study, we can conclude that gold nanoparticles and flavonoids-loaded-GNPs showed higher efficiency in the treatment of the infection with Giardia lamblia than metronidazole.

show abstract

“…In general, CS nanoparticles are found interesting due to the excellent solubility of hydrophobic drugs, their permeability through biological membranes, and improved transfer of active agents to the target area. Among the world’s latest reports there are e.g., injectable cisplatin-loaded CS nanoparticles [ 68 ] or N-2-hydroxypropyl trimethyl ammonium chloride chitosan and N,O-carboxymethyl chitosan nanoparticles with encapsulated amoxicillin [ 69 ]. An interesting application for CS nanocarriers has been proposed by Dharshini et al [ 70 ].…”

Section: Chitosanmentioning

confidence: 99%

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

Kurczewska

2022

Polymers

View full text Add to dashboard Cite

Polysaccharides constitute one of the most important families of biopolymers. Natural polysaccharide-based drug delivery systems are of constant interest to the scientific community due to their unique properties: biocompatibility, non-toxicity, biodegradability, and high availability. These promising biomaterials protect sensitive active agents and provide their controlled release in targeted sites. The application of natural polysaccharides as drug delivery systems is also intensively developed by Polish scientists. The present review focuses on case studies from the last few years authored or co-authored by research centers in Poland. A particular emphasis was placed on the diversity of the formulations in terms of the active substance carried, the drug delivery route, the composition of the material, and its preparation method.

show abstract

Amoxicillin encapsulated in the N-2-hydroxypropyl trimethyl ammonium chloride chitosan and N,O-carboxymethyl chitosan nanoparticles: Preparation, characterization, and antibacterial activity

Cited by 10 publications

References 48 publications

Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications

Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications

Anti-Giardia Activity of Gold Nanoparticle and Flavonoid-Loaded Gold Nanoparticles

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

Contact Info

Product

Resources

About