Amoxicillin-associated rash in glandular fever

Fox, Richard; Ghedia, Reshma; Nash, Robert

doi:10.1136/bcr-2015-211622

Cited by 5 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is well known that some antibiotics, notably amoxicillin and ampicillin, can lead to severe generalized rashes in patients with EBV infection. 23 This was not observed in this case.…”

Section: Discussioncontrasting

confidence: 47%

Acute Epstein-Barr virus hepatitis presenting clinically as ascending cholangitis in an immunocompetent patient

Colbran

2020

Int Surg J

View full text Add to dashboard Cite

Symptomatic acute Epstein-Barr virus (EBV) hepatitis, without associated infectious mononucleosis syndrome, is exceptionally rare. A 30-year-old female presented to hospital with jaundice, fevers, and right upper quadrant abdominal pain. Her blood tests demonstrated marked hyperbilirubinemia and mild global liver function test abnormalities consistent with obstructive jaundice. Preliminary imaging with ultrasound showed gallbladder wall thickening and cholelithiasis, suggestive of potential cholecystitis. Authors were concerned for potential ascending cholangitis in the setting of her hyperbilirubinemia. The diagnosis was refuted after magnetic resonance cholangiopancreatography demonstrated no choledocholithiasis. A hepatic panel was performed which revealed positive EBV IgM serology. This case highlights the importance of considering EBV hepatitis as a potential differential diagnosis in patients with right upper quadrant pain, fevers and jaundice in the absence of an obstructing cause.

show abstract

“…It is well known that some antibiotics, notably amoxicillin and ampicillin, can lead to severe generalized rashes in patients with EBV infection. 23 This was not observed in this case.…”

Section: Discussioncontrasting

confidence: 47%

Acute Epstein-Barr virus hepatitis presenting clinically as ascending cholangitis in an immunocompetent patient

Colbran

2020

Int Surg J

View full text Add to dashboard Cite

show abstract

“…Recent findings show that EBV IM has been consistently associated with MS this contrasts with CMV IM which shows an inverse association [17 One of the key challenges for treating practitioners, is the prompt distinction of bacterial tonsillitis from IM, which presents with pharyngitis. Inappropriate antibiotic treatment for a bacterial tonsillitis in IM cases can result in a high percentage of patients developing an ampicillin rash owing to a transient penicillin hypersensitivity occurring during the early acute stage of the viral infection [20][21][22].…”

Section: Clinical Presentationmentioning

confidence: 99%

Infectious mononucleosis: new concepts in clinical presentation, epidemiology, and host response

Naughton,

Enright,

Lucey

2024

Current Opinion in Infectious Diseases

View full text Add to dashboard Cite

Purpose of the review Infectious mononucleosis (IM) is an infectious disease that presents clinically in only a small percentage of individuals despite almost universal infection with the causative agent. Here, we review the latest concepts in the clinical presentation, epidemiology, and host response of this disease. Recent findings Several recently published papers/reviews describe IM as a condition caused by one of several etiologic agents including, cytomegalovirus (HHV-5), Roseola virus (HHV-6) and Toxoplasmosis amongst others; this review focuses on IM as solely caused by the human herpes virus 4 (HHV-4). Since the initial discovery of the virus in the 1960s and its subsequent discovery as the primary etiologic agent for IM it has been associated with several human cancers and autoimmune disorders. Recent published findings show a correlation between HHV-4 and the autoimmune disorder, multiple sclerosis (MS), suggesting earlier IM could possibly act as a causative factor. Considering the important links being made with IM to so many cancers and autoimmune disorders it is surprising that a standard investigative procedure has yet to be determined for this disease. A standard approach to the investigation of IM would ensure more cases are diagnosed, particularly atypical cases, this would benefit epidemiological studies, and more immediately help practitioners distinguish viral from bacterial throat infections, enabling them to treat accordingly. Summary The understanding of the latest concepts in clinical presentation, epidemiology and host response to IM would benefit greatly from the introduction of a standard procedure for its investigation and diagnosis.

show abstract

“…In most cases, this skin reaction occurs after treatment with aminopenicillins; it is less frequently observed without drug involvement. Affection of the mucous membranes with enanthema and ulcerations may also occur [3, 4]. Maculopapular eruptions are also frequently seen after infection with HHV5, better known as cytomegalovirus or CMV.…”

Section: Human Herpes Virusesmentioning

confidence: 99%

Infections with Herpes simplex and Varicella zoster virus

Wilms

Weßollek

Peeters

et al. 2022

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Summary Human herpes viruses belong to the DNA viruses and are among the most common viral pathogens. Currently, eight human herpes viruses have been characterized. Primary infection is typically followed by virus latency. Viral reactivations are more often symptomatic than primary infections and lead more often to medical consultation. In daily practice, infections with herpes simplex virus (HSV) and varicella zoster virus (VZV) are the most common. If HSV primary infections become clinically manifest, they are often accompanied by systemic symptoms whereas manifest HSV reactivations are usually harmless, self‐limiting and present as grouped vesicles on an erythematous base (herpetiform). Primary VZV infection leads to the clinical picture of varicella (chickenpox). VZV reactivation manifests clinically as shingles and can be accompanied by severe acute neuralgiform pain. In immunosuppression, complicated (necrotizing, ulcerative, hemorrhagic, generalized) manifestations may occur. The diagnosis is usually made clinically. Therapeutic options include topical agents and systemic antivirals. Adequate therapeutic management includes the recognition and treatment of complications such as the possible involvement of other organ systems and pain. Infection during pregnancy may result in transmission to the unborn child.

show abstract

Amoxicillin-associated rash in glandular fever

Cited by 5 publications

References 3 publications

Acute Epstein-Barr virus hepatitis presenting clinically as ascending cholangitis in an immunocompetent patient

Acute Epstein-Barr virus hepatitis presenting clinically as ascending cholangitis in an immunocompetent patient

Infectious mononucleosis: new concepts in clinical presentation, epidemiology, and host response

Infections with Herpes simplex and Varicella zoster virus

Contact Info

Product

Resources

About