Amounts of Interstitial Cell-Stimulating Hormone and Follicle-Stimulating Hormone Required for Follicular Development, Uterine Growth and Ovulation in the Hypophysectomized Rat1

Lostroh, Ardis J.; Johnson, Ruth E.

doi:10.1210/endo-79-5-991

Cited by 100 publications

(36 citation statements)

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“…The observation that FSH stimulated the development of antral follicles is in agreement with the work of Hirshfield & Midgley (1978) Although these studies do not completely eliminate the possibility that LH has a permissive effect, they suggest that, in mice at least, an increase in the plasma LH concentration, on its own, is not sufficient to stimulate antral follicle development, and FSH is also required for this process, as was suggested by Lostroh & Johnson (1966 In normal mice the size of the interstitial compartment increases with increasing age and this has been attributed to the formation of interstitial cells from follicular cells, largely by the trans¬ formation of thecal cells (Peters & Levy, 1966). They possess LH receptors (Charlton et al, 1982) and resemble typical steroid-secreting cells (Mutta, 1958;Fawcett et al, 1969).…”

Section: Discussionsupporting

confidence: 81%

Effects of short-term injection of gonadotrophins on ovarian follicle development in hypogonadal (hpg) mice

Halpin¹,

Charlton²

1988

Reproduction

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Section: Discussionsupporting

confidence: 81%

Effects of short-term injection of gonadotrophins on ovarian follicle development in hypogonadal (hpg) mice

Halpin¹,

Charlton²

1988

Reproduction

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“…Gonadotropin secretion at diestrus II is responsible for an increase of estrogen secretion (Bourdel and Li, 1963 ;Lostroh and Johnson, 1966), which has been shown to increase on the afternoon of the same day (Hori et al, 1968). Therefore, it is possible that a neural structure, which is responsible for the gonadotropin release on the day of diestrus II, may stimulate the anterior pituitary gland sometime between 18: 00 on the day of diestrus I and 6: 00 on the day of diestrus II.…”

Section: Discussionmentioning

confidence: 99%

Acute Effect of Neural Deafferentation on Timing of Gonadotropin Secretion Before Proestrus in the Female Rat

Kawakami

Terasawa

1972

Endocrinol Japon

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SynopsisAn attempt was made to investigate a role of the brain on release of gonadotropin responsible for the events of proestrus and estrus in the 4-day cyclic rats. Rats were acutely deafferented at the level of anterior commissure (AC) with three kinds of the L-shaped knives at the different time of day, and autopsied to examine the uterine distension and ovulation on the days of expected proestrus or estrus. Serum and pituitary level of LH, FSH and prolactin in the deafferented rats were measured by radioimmunoassay. The results are as follows: 1) With an L-shaped knife of 2.5 mm of the horizontal blade (knife A) the fornix (Fx) and the stria terminalis (ST) were interrupted and simultaneously the tract of diagonal bundle of Broca (TDB), the bed nucleus of stria terminalis (BST), the nucleus of accumbens (ACC), the nucleus of anterior commissure (NAC) and parolfactory area were commonly damaged. The deafferentation at 20:00 on the day of diestrus I prevented vaginal cornification, uterine distension and ovulation on the expected estrous day. Full cornification was observed in all examined rats with transection after 10:00 on the day of diestrus II, while uterine distension was not observed in the rats with transection before 20:00 on the same day. None of rats bearing the transection ovulated on the day of estrus, even the transection was performed at 8:00 on the day of proestrus. 2) With an L-shaped knife of 1.4 mm of the horizontal blade (knife B) the Fx were interrupted and the BAC and the TDB were commonly damaged, however, the ST, the BST and the ACC were only partially damaged. Most of results following to the neural transection with knife B were similar to those observed with knife A except for ovulation being observed in the rats transected at 8:00 on the day of proestrus. However, transection at the mid-thalamus (knife placed at 2 mm caudal to the AC) did not interfere any normal cyclic changes. 3) Estrogen injection into the rats transected with knife B at 20:00 on the day of diestrus II resulted in inducing ovulation, while with knife A did not. 4) Transection either Fx or medial cortico-hypothalamic tract (CHT) with an L-shaped knife of 1.0 mm of the horizontal blade (knife C) on the day of diestrus I partially prevented the occurrence of events of proestrus and estrus. 5) Transection of the septal complex with knife B at 20:00 on the day of diestrus I prevented a rise of pituitary LH, pituitary prolactin and serum prolactin, which used to be observed in normal proestrus. Both Fx and CHT transection resulted in an increase of pituitary FSH. From the ovariectomy experiment the ovary of the our colony's rats must be in situ at 15:00 for vaginal cornification and at 24:00 for uterine distension. Thus, following facts are suggested 1) the septal complex or higher brain such as the limbic structure may be involved in the release of gonadotropin responsible for the events of proestrus and estrus, 2) timing of release of gonadotropin (folliculotropin) might occur preceding to the ovarian changes and it ...

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“…Either FSH or LH can cause luteinization of follicles and increased progesterone secretion (125,180), and both may be controlled by one releasing-factor (83). In the hypophysectomized female both LH and FSH are necessary for optimum estrogen secretion and follicle growth, but either hormone will cause ovulation once the animal is pretreated with both hormones (123). Whichever factor is responsible for ovulation, luteinization follows.…”

mentioning

confidence: 99%

Adrenal Involvement in Determining the Time of Onset of Puberty in the Rat1

Gorski

Lawton

1973

Endocrinology

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Amounts of Interstitial Cell-Stimulating Hormone and Follicle-Stimulating Hormone Required for Follicular Development, Uterine Growth and Ovulation in the Hypophysectomized Rat1

Cited by 100 publications

References 0 publications

Effects of short-term injection of gonadotrophins on ovarian follicle development in hypogonadal (hpg) mice

Effects of short-term injection of gonadotrophins on ovarian follicle development in hypogonadal (hpg) mice

Acute Effect of Neural Deafferentation on Timing of Gonadotropin Secretion Before Proestrus in the Female Rat

Adrenal Involvement in Determining the Time of Onset of Puberty in the Rat1

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