Amount and Distribution of Carbonic Anhydrases CA I and CA II in the Gastrointestinal Tract

Lönnerholm, Gudmar; Selking, Örjan; Wistrand, Per J.

doi:10.1016/s0016-5085(85)80074-3

Cited by 77 publications

(30 citation statements)

References 34 publications

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“…The striking regional differences in CA activity along the cranial-caudal axis suggest important regulatory roles for CA in these processes. Stomach (20). CA II is the dominant, if not only, cytosolic isozyme in the stomach of rats, humans, and most mammals (although CA I is present in the rumen epithelium of some ruminants).…”

Section: Discussionmentioning

confidence: 99%

“…In rat colon, CA I and II are both present and contribute about equally to total activity. In addition to cytosolic CA activity, histochemical studies of the rat gut have demonstrated membrane-associated CA activity in several regions (20). Membrane-associated CA activity has also been detected in isolated membranous vesicles from rabbit ileum (21).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Carbonic anhydrase IV expression in rat and human gastrointestinal tract regional, cellular, and subcellular localization.

Fleming¹,

Parkkila²,

Parkkila³

et al. 1995

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Carbonic anhydrase IV expression in rat and human gastrointestinal tract regional, cellular, and subcellular localization.

Fleming¹,

Parkkila²,

Parkkila³

et al. 1995

J. Clin. Invest.

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“…Although such a function may be meaningful in electrolyte transporting epithelia such as the absorptive intestinal epithelium (7). or Ihe kidney epithelium (3).…”

Section: Discussionmentioning

confidence: 99%

Carbonic anhydrase—a marker for particles shed from the epithelium to the lymphoid follicles of the ileal Peyer's patch in goat kids and lambs

Landsverk

Jansson

Nicander³

et al. 1987

Immunol Cell Biol

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Summary Carbonic anhydrase (CA) was found to be a marker for 50 nanometer membrane‐bounded particles shed from the lateral cell border of follicle‐associated epithelial cells (FAE) in the ileal Peyer's patch (PP) of pre‐ and post‐natal lambs and goat kids. The CA‐positive particles seemed to filter into the underlying lymphoid tissue where they formed part of the matrix embedding the cells of the follicle centre.

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“…Vascular smooth muscle CA I was isolated from the small mesenteric arteries of the animals according to the technique of Lonnerholm et al (8).…”

Section: Methodsmentioning

confidence: 99%

“…CA I is present both in erythrocytes and in vascular walls and its physiologic role has been incompletely elucidated (8). CA II is to be found both in erythrocytes and in the cytoplasm.…”

Section: Introductionmentioning

confidence: 99%

Catecholamine-induced vasoconstriction is sensitive to carbonic anhydrase I activation

Puşcaş¹,

Coltâu²,

Gilau³

et al. 2001

Braz J Med Biol Res

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We studied the relationship between alpha-and beta-adrenergic agonists and the activity of carbonic anhydrase I and II in erythrocyte, clinical and vessel studies. Kinetic studies were performed. Adrenergic agonists increased erythrocyte carbonic anhydrase as follows: adrenaline by 75%, noradrenaline by 68%, isoprenaline by 55%, and orciprenaline by 62%. The kinetic data indicated a non-competitive mechanism of action. In clinical studies carbonic anhydrase I from erythrocytes increased by 87% after noradrenaline administration, by 71% after orciprenaline and by 82% after isoprenaline. The increase in carbonic anhydrase I paralleled the increase in blood pressure. Similar results were obtained in vessel studies on piglet vascular smooth muscle. We believe that adrenergic agonists may have a dual mechanism of action: the first one consists of a catecholamine action on its receptor with the formation of a stimulus-receptor complex. The second mechanism proposed completes the first one. By this second component of the mechanism, the same stimulus directly acts on the carbonic anhydrase I isozyme (that might be functionally coupled with adrenergic receptors), so that its activation ensures an adequate pH for stimulus-receptor coupling for signal transduction into the cell, resulting in vasoconstriction. Correspondence

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Amount and Distribution of Carbonic Anhydrases CA I and CA II in the Gastrointestinal Tract

Cited by 77 publications

References 34 publications

Carbonic anhydrase IV expression in rat and human gastrointestinal tract regional, cellular, and subcellular localization.

Carbonic anhydrase IV expression in rat and human gastrointestinal tract regional, cellular, and subcellular localization.

Carbonic anhydrase—a marker for particles shed from the epithelium to the lymphoid follicles of the ileal Peyer's patch in goat kids and lambs

Catecholamine-induced vasoconstriction is sensitive to carbonic anhydrase I activation

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