Amorphous phase-mediated crystallization of calcium pyrophosphate tetrahydrate: the role of alkaline earth metal ions

Abstract

Although calcium pyrophosphates are commonly involved in crystal arthropathies, their formation mechanisms remain largely underexplored. Here, we investigated the crystallization pathway of calcium pyrophosphate tetrahydrate in the absence and presence...

Influence of Glycyl‐L‐Glutamic Acid Dipeptide on Calcium Pyrophosphate Dihydrate Crystallization

“…These crystal deposits can cause significant morbidity and are often underdiagnosed [1][2][3][4][5][6]. The disease is idiopathic in most patients; however, it has been associated with aging, osteoarthritis, gout, hyperparathyroidism, and metabolic disorders such as hemochromatosis and hypomagnesemia [7][8][9][10]. Although it mainly presents in the elderly, arthritis caused by these crystals is the third most common form of inflammatory arthritis [11].…”