Amorphous nano-selenium quantum dots improve endothelial dysfunction in rats and prevent atherosclerosis in mice through Na+/H+ exchanger 1 inhibition

Zhu, Mo‐Li; Wang, Ge; Wang, He; Guo, Yuming; Song, Ping; Xu, Jian; P, Li; Wang, Shuangxi; Yang, Lin

doi:10.1016/j.vph.2019.01.005

Cited by 34 publications

(33 citation statements)

References 31 publications

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“…The safe dose range of selenium in organism is very narrow. It is easy to produce toxicity due to overdose, which limits the application of traditional selenium compounds [7]. Compared with traditional selenium compounds, nano-selenium has unique physical and chemical properties, high activity, and low toxicity [8,9].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis and antioxidation of nano-selenium using lemon juice as a reducing agent

Yang

Wang

2021

Green Processing and Synthesis

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Nano-selenium was synthesized using lemon juice as a reducing agent. The experiments showed that pH value affected greatly the shape and the size of the prepared nano-selenium. At pH 9, lemon juice could reduce 50 mmol/L of selenite ions to nano-selenium with particle size between 50 and 90 nm, which was spherical and well dispersed. Lemon juice acted as both a reducing agent and a stabilizer in the synthesis of nano-selenium, in which the chemical interaction between biomolecules and the nano-selenium surface was the basis for the stable existence of nano-selenium. The selenite concentration influenced the formation of nano-selenium, and a low selenite concentration was beneficial to obtain small particles. The achieved nano-selenium exhibited a strong antioxidant activity positively related to concentration. The comparative study showed that the antioxidation of nano-selenium is weaker than that of vitamin C but higher than that of lemon juice.

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Section: Introductionmentioning

confidence: 99%

Biosynthesis and antioxidation of nano-selenium using lemon juice as a reducing agent

Yang

Wang

2021

Green Processing and Synthesis

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“…Pulmonary exposure of some engineered NPs, such as single-walled carbon nanotubes (SWCNTs), TiO 2 , nickel hydroxide and indium oxide NPs could accelerate the pathological progress of atherosclerosis [ 21 – 24 ]. But selenium NPs were recently reported to alleviate hyperlipidemia and vascular injury [ 25 ], and also, amorphous selenium quantum dots (A-SeQDs) was confirmed to prevent atherosclerosis in vivo [ 26 ]. So far, the effects of SiNPs on the formation and progression of atherosclerotic plaque is still poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Amorphous silica nanoparticles accelerated atherosclerotic lesion progression in ApoE−/− mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage

Zhao

et al. 2020

Part Fibre Toxicol

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Background The biosafety concern of silica nanoparticles (SiNPs) is rapidly expanding alongside with its mass production and extensive applications. The cardiovascular effects of SiNPs exposure have been gradually confirmed, however, the interaction between SiNPs exposure and atherosclerosis, and the underlying mechanisms still remain unknown. Thereby, this study aimed to explore the effects of SiNPs on the progression of atherosclerosis, and to investigate related mechanisms. Results We firstly investigated the in vivo effects of SiNPs exposure on atherosclerosis via intratracheal instillation of ApoE−/− mice fed a Western diet. Ultrasound microscopy showed a significant increase of pulse wave velocity (PWV) compared to the control group, and the histopathological investigation reflected a greater plaque burden in the aortic root of SiNPs-exposed ApoE−/− mice. Compared to the control group, the serum levels of total triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) were elevated after SiNPs exposure. Moreover, intensified macrophage infiltration and endoplasmic reticulum (ER) stress was occurred in plaques after SiNPs exposure, as evidenced by the upregulated CD68 and CHOP expressions. Further in vitro, SiNPs was confirmed to activate ER stress and induce lipid accumulation in mouse macrophage, RAW264.7. Mechanistic analyses showed that 4-PBA (a classic ER stress inhibitor) pretreatment greatly alleviated SiNPs-induced macrophage lipid accumulation, and reversed the elevated CD36 expression induced by SiNPs. Conclusions Our results firstly revealed the acceleratory effect of SiNPs on the progression of atherosclerosis in ApoE−/− mice, which was related to lipid accumulation caused by ER stress-mediated upregulation of CD36 expression in macrophage. Graphical abstract

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“…A therosclerosis is caused by the deposition of fat, thrombi, connective tissue, and calcium carbonate in blood vessels [1][2][3] and includes aortal atherosclerosis, coronary atherosclerosis, cerebral atherosclerosis, renal atherosclerosis, and others. [4][5][6][7] In light of the third report by the World Health Organization (Geneva, Switzerland), 10 million people die of cardiovascular disease caused by atherosclerosis annually around the world.…”

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confidence: 99%

Comparison of the Diagnostic Performances of Ultrasound, High‐Resolution Magnetic Resonance Imaging, and Positron Emission Tomography/Computed Tomography in a Rabbit Carotid Vulnerable Plaque Atherosclerosis Model

Wang

Liu

et al. 2020

J of Ultrasound Medicine

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Objectives-Our study aimed to evaluate the diagnostic performances of 3 routine examination methods for cerebrovascular disease in a rabbit carotid artery atherosclerosis model. Methods-A total of 12 New Zealand rabbits were included: 4 in a control group and 8 in an experimental group. A clinically relevant atherosclerosis rabbit model was induced by left common carotid artery ligation and a 12-week highfat diet. Atherosclerosis was further confirmed by a histopathologic analysis. Then carotid ultrasound (US) imaging, high-resolution magnetic resonance imaging (HRMRI), and positron emission tomography (PET)/computed tomography (CT) were performed on this model to evaluate the diagnostic performances. Results-Carotid US showed plaque formation in the left common carotid artery and little plaque in the right common carotid artery in the experimental group. In addition, HRMRI showed stenosis formation in the left common carotid artery in the experimental group. At the horizontal level, plaques were found in the left common carotid artery, and no plaques were found in the right common carotid artery in the experimental group. Also, PET/CT showed local hypermetabolism and vulnerable plaques in the left common carotid artery of the experimental group, whereas no hypermetabolism was found in the right common carotid artery of the experimental group. Moreover, the soft plaques detected by carotid US were different from the vulnerable plaques detected by PET/CT. The unstable plaques on HRMRI were the same as the hypermetabolic vulnerable plaques on PET/CT. Conclusions-High-resolution MRI is recommended for the evaluation of neck and intracranial vascular stenosis and plaque properties in patients with stroke.

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Amorphous nano-selenium quantum dots improve endothelial dysfunction in rats and prevent atherosclerosis in mice through Na+/H+ exchanger 1 inhibition

Cited by 34 publications

References 31 publications

Biosynthesis and antioxidation of nano-selenium using lemon juice as a reducing agent

Biosynthesis and antioxidation of nano-selenium using lemon juice as a reducing agent

Amorphous silica nanoparticles accelerated atherosclerotic lesion progression in ApoE−/− mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage

Comparison of the Diagnostic Performances of Ultrasound, High‐Resolution Magnetic Resonance Imaging, and Positron Emission Tomography/Computed Tomography in a Rabbit Carotid Vulnerable Plaque Atherosclerosis Model

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