Among potent men post radical prostatectomy, does the need for phosphodiesterase inhibitors have an impact on sexual bother scores?

Abstract

OBJECTIVE To determine whether the current definition of potency, inclusive of phosphodiesterase inhibitor (PDEi) use, is valid with respect to sexual bother (SB). This will be assessed by characterizing the effect of PDEi use on SB scores in men who are potent post radical prostatectomy. PATIENTS AND METHODS The study population consisted of patients who were potent both before and after radical prostatectomy, with at least 2 years of follow-up. Disease-specific quality of life data were evaluated by the University of California, Los Angeles, Prostate Cancer Index (PCI) survey. The relationships between changes in sexual function (SF) and SB and use of PDEi over time were evaluated by mixed model analysis controlling for age, clinical risk group, marital status, and time of PCI assessment. RESULTS Of the 246 patients who met the study criteria, 39% reported PDEi use at some point after treatment. PDEi use was not associated with improved SF (P = 0.81). Furthermore, PDEi use was not associated with a change in SB (P = 0.36). Both SF and SB were significantly associated with time of assessment and age, and SF and SB each improved over time. In addition, SB was significantly associated with marital status. CONCLUSION In this analysis, there was no difference in SF scores between men who were potent with or without the use of PDEi. Furthermore, there was no difference in SB scores between men who were potent with or without the use of PDEi. This suggests that the current, inclusive, definition of potency is valid with respect to SB.

Patient-reported outcomes following stereotactic body radiation therapy for clinically localized prostate cancer

“…While a small portion of the decline may be attributed to increasing age and the natural progression of erectile dysfunction, it is unlikely that age would be the sole reason for this decline. Multiple sexual aids exist to improve sexual function and may alleviate bother [ 31 ]. Patients may benefit from education regarding these available and effective enhancement tools.…”

The epidemiology of high-risk prostate cancer

“…Studies examining nutrition and prostate cancer have yielded heterogeneous results, but the number of studies assessing the impact of nutrition on high-risk prostate cancer are limited [34]. One recent case-control study focused on aggressive prostate cancer found that a higher intake of well done, grilled, or barbequed red meat and its ensuing carcinogens (heterocyclic amines) could increase the risk of aggressive prostate cancer [35]. The link between nutrition and aggressive prostate cancer remains incompletely defined, and is a focus of ongoing studies.…”

Sexualidade e qualidade de vida em homens com dificuldades sexuais

“…É vasta a literatura sobre o impacto das doenças crônicas e seus tratamentos sobre a qualidade de vida (QV) e a função sexual de homens e mulheres. Podemos citar como exemplos estudos que investigaram a relação entre QV, satisfação sexual e doenças como depressão, insuficiência renal e câncer (Bertam & Castro, 2010;Nóra, Zambone & Facio Júnior, 2009;Rosen & cols., 2004); pesquisas que avaliam o impacto de tratamentos na QV, tais como a prostatectomia radical (Coelho & cols., 2003;Kamalov & cols., 2005;Punnen, Cooperberg, Sadetsky & Carroll, 2012;Van Andel & cols, 2004); ou ainda, estudos que avaliam as alterações da função sexual inerentes ao envelhecimento (Sousa, 2008;Viana & Madruga, 2008).…”