Amomum villosumLour. fruit extract ameliorates high-fat diet-induced body mass gain and adipogenic pathways in C57BL/6 mice

Kim, Ha-Rim; Antonisamy, Paulrayer; Kim, Ye-Seul; Kwon, Yong-Gwan; Ryu, Do-Gon; Lee, Young‐Rae; Lee, Guemsan; Ham, Hyang-Do; Kwon, Kang‐Beom

doi:10.1016/j.jksus.2021.101473

Cited by 7 publications

(3 citation statements)

References 16 publications

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“…Similar results were also found in the report by Fan et al ( 13 ) who found that catechin and epicatechin were the predominant phenolic compounds in Fr-EtOAc of A. tsaoko . Although some reports confirmed that the water extract of A. villosum had many biological activities ( 7 , 8 ), there was not much research on the composition of phenolic compounds from A. villosum . And this is the first time to report the composition of phenolic compounds from the seeds of A. villosum .…”

Section: Resultsmentioning

confidence: 99%

“…As previously reported, Tang et al ( 4 ) found that A. villosum volatile oil exhibited antibacterial activity by interfering with the metabolism of methicillin-resistant Staphylococcus aureus , and the report described by Liu et al ( 5 ) revealed that A. villosum polysaccharides could reduce gastric mucosal injury by promoting the level of reactive oxygen species and inflammatory factors. Although there were several studies on the biological activities of the water extract of A. villosum , including absorption characteristics ( 6 ), weight loss ( 7 ), mitigate hyperlipidemia ( 8 ), the composition of phenolic compounds from A. villosum was still unclear, which restricted the further utilization of A. villosum .…”

Section: Introductionmentioning

confidence: 99%

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Characterization, antioxidant and antitumor activities of phenolic compounds from Amomum villosum Lour.

Zhang,

Shuai,

Wei

et al. 2024

Front. Nutr.

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Amomum villosum Lour. (A. villosum), known as Sharen in China, is widely used for culinary and medicinal purposes due to containing a diverse set of bioactive compounds. In this study, the optimum ethanol extraction process was optimized and the composition and biological activities (antioxidant and antitumor) of five different fractions (dichloromethane, petroleum ether, ethyl acetate, n-butanol and H2O) extracted from the ethanol extract of A. villosum were investigated. The results showed that the optimal extraction conditions were extraction temperature 80°C, extraction time 120 min, ethanol concentration 40% and solid–liquid ratio 1:25 g/mL. Moreover, 35 bioactive compounds were successfully identified by UPLC-ESI-QTOF-MS/MS from five factions for the first time, including 12 phenolic acids and derivatives, 2 organic acids, 12 flavonoids and derivatives, 2 oxylipins and 7 proanthocyanidins. Among them, ethyl acetate fraction (Fr-EtOAc) exhibited the highest content of total phenolic (374.01 mg GAE/g DW) and flavonoid (93.11 mg RE/g DW), where vanillic acid, catechin, epicatechin and protocatechuic acid were the predominant phenolic compounds that accounting for 81.65% of the quantified bioactive compounds. In addition, Fr-EtOAc demonstrated excellent total antioxidant activity (IC50 of DPPH and ABTS assays were 0.23, 0.08 mg/mL, respectively, and FRAP assay was 322.91 mg VCE/100 g DW) and antitumor activity (1,000 μg/mL, 79.04% inhibition rate). The results could provide guidance for the industrial production and application of A. villosum.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization, antioxidant and antitumor activities of phenolic compounds from Amomum villosum Lour.

Zhang,

Shuai,

Wei

et al. 2024

Front. Nutr.

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“…Amomum villosum Lour., which belongs to the Zingiberaceae family in classic traditional Chinese herbal plant, has been widely used in the management of numerous diseases [ 7 ]. Although Amomum villosum with affluent biological activities has been used to treat stomach diseases and gastrointestinal diseases, its role in the treatment of gout remains unclear [ 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Vanillic Acid as a Promising Xanthine Oxidase Inhibitor: Extraction from Amomum villosum Lour and Biocompatibility Improvement via Extract Nanoemulsion

Zhou

Wang

et al. 2022

Foods

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Gout is an oxidative stress-related disease. Food-derived vanillic acid, a promising xanthine oxidase inhibitor, could potentially be used as a safe, supportive, and therapeutic product for gout. The extraction of vanillic acid from a classic Chinese herbal plant Amomum villosum with ethanol was investigated in the study. The optimum conditions were determined as extraction time of 74 min, extraction temperature of 48.36 °C, and a solid-to-liquid ratio of 1:35 g·mL−1 using the Box–Behnken design (BBD) of response surface methodology (RSM). The experimental extraction yield of 9.276 mg·g−1 matched with the theoretical value of 9.272 ± 0.011 mg·g−1 predicted by the model. The vanillic acid in Amomum villosum was determined to be 0.5450 mg·g−1 by high-performance liquid chromatography–diode array detection (HPLC–DAD) under the optimum extraction conditions and exhibited xanthine oxidase (XO) inhibitory activity, with the half-maximal inhibitory concentration (IC50) of 1.762 mg·mL−1. The nanoemulsion of Amomum villosum extract consists of 49.97% distilled water, 35.09% Smix (mixture of tween 80 and 95% ethanol with 2:1 ratio), and 14.94% n-octanol, with a particle size of 110.3 ± 1.9 nm. The nanoemulsion of Amomum villosum extract exhibited markable XO inhibitory activity, with an inhibition rate of 58.71%. The result demonstrated the potential benefit of Amomum villosum as an important dietary source of xanthine oxidase inhibitors for gout.

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Health-promoting compounds in Amomum villosum Lour and Amomum tsao-ko: Fruit essential oil exhibiting great potential for human health

Imran,

Bibi,

Yang

et al. 2024

Heliyon

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Amomum villosumLour. fruit extract ameliorates high-fat diet-induced body mass gain and adipogenic pathways in C57BL/6 mice

Cited by 7 publications

References 16 publications

Characterization, antioxidant and antitumor activities of phenolic compounds from Amomum villosum Lour.

Characterization, antioxidant and antitumor activities of phenolic compounds from Amomum villosum Lour.

Vanillic Acid as a Promising Xanthine Oxidase Inhibitor: Extraction from Amomum villosum Lour and Biocompatibility Improvement via Extract Nanoemulsion

Health-promoting compounds in Amomum villosum Lour and Amomum tsao-ko: Fruit essential oil exhibiting great potential for human health

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