Amoeboid swimming in a compliant channel

Dalal, Swapnil; Farutin, Alexander; Misbah, Chaouqi

doi:10.1039/c9sm01689a

Cited by 14 publications

(8 citation statements)

References 88 publications

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“…(2018) examined the behaviour of a three-sphere microswimmer in a channel bounded by two walls, where different swimming states have been observed. More recently, amoeboid swimming in a compliant channel was numerically investigated (Dalal, Farutin & Misbah 2020).…”

Section: Introductionmentioning

confidence: 99%

Axisymmetric Stokes flow due to a point-force singularity acting between two coaxially positioned rigid no-slip disks

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Axisymmetric Stokes flow due to a point-force singularity acting between two coaxially positioned rigid no-slip disks

et al. 2020

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“…We will analyze below the effect of the relevant blood flow and geometrical parameters on the rheological behavior of vesicle doublet and discuss the mechanism of separation. In order to preserve high accuracy we use Fourier basis discretization of all functions and compute all derivatives in Fourier domain [37,38]. At high shear rates numerical stability problems may arise.…”

Section: B Boundary Integral Formulationmentioning

confidence: 99%

Erythrocyte-erythrocyte aggregation dynamics under shear flow

Abbasi,

Farutin,

Ez-Zahraouy

et al. 2020

Preprint

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Red blood cells (RBCs) -erythrocytes-suspended in plasma tend to aggregate and form rouleaux. During aggregation the first stage consists in the formation of RBC doublets [Blood cells, molecules, and diseases 25, 339 (1999)]. While aggregates are normally dissociated by moderate flow stresses, under some pathological conditions the aggregation becomes irreversible, which leads to high blood viscosity and vessel occlusion. We perform here two-dimensional simulations to study the doublet dynamics under shear flow in different conditions and its impact on rheology. We sum up our results on the dynamics of doublet in a rich phase diagram in the parameter space (flow strength, adhesion energy) showing four different types of doublet configurations and dynamics. We find that membrane tank-treading plays an important role in doublet disaggregation, in agreement with experiments on RBCs. A remarkable feature found here is that when a single cell performs tumbling (by increasing vesicle internal viscosity) the doublet formed due to adhesion (even very weak) remains stable even under a very strong shear rate. It is seen in this regime that an increase of shear rate induces an adaptation of the doublet conformation allowing the aggregate to resist cell-cell detachment. We show that the normalized effective viscosity of doublet suspension increases significantly with the adhesion energy, a fact which should affect blood perfusion in microcirculation.

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“…Inspired by these recent experimental discoveries of amoeboid mode of swimmingin the strict sense of adhesion-independent cell-fluid interaction that involves large-scale of cell shape deformations, it is timely to conduct a modeling study on chemotaxis driven Dd swimming that allows the coupling of signaling dynamics and biohydrodynamics. In recent years, several models for single cell amoeboid swimming have emerged, many focus on exploring the fluid-structure interaction in the system and how the amoeboid style of shape deformations lead to swimming in various viscous fluid environments [39][40][41][42][43][44][45], some also consider the underlying membrane protein kinetics that regulate the excitable dynamics of the the cell membrane deformations [46,47]. In this paper, we develop a model that includes a deforming Dd amoeboid cell and a group of bacteria, where the amoeboid cell swims following chemoattractant signal produced by the bacteria.…”

Section: Introductionmentioning

confidence: 99%

Mathematical modeling of chemotaxis guided amoeboid cell swimming

Wang¹,

Wu²

2021

Phys. Biol.

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Cells and microorganisms adopt various strategies to migrate in response to different environmental stimuli. To date, many modeling research has focused on the crawling-based Dictyostelium discoideum (Dd) cells migration induced by chemotaxis, yet recent experimental results reveal that even without adhesion or contact to a substrate, Dd cells can still swim to follow chemoattractant signals. In this paper, we develop a modeling framework to investigate the chemotaxis induced amoeboid cell swimming dynamics. A minimal swimming system consists of one deformable Dd amoeboid cell and a dilute suspension of bacteria, and the bacteria produce chemoattractant signals that attract the Dd cell. We use the mathematical amoeba model to generate Dd cell deformation and solve the resulting low Reynolds number flows, and use a moving mesh based finite volume method to solve the reaction-diffusion-convection equation. Using the computational model, we show that chemotaxis guides a swimming Dd cell to follow and catch bacteria, while on the other hand, bacterial rheotaxis may help the bacteria to escape from the predator Dd cell.

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Amoeboid swimming in a compliant channel

Abstract: We studied influence of elasticity of surrounding environment on cell motility by numerically investigating effects of wall flexibility and channel confinement on flow dynamics of amoeboid swimming in compliant channel.

Cited by 14 publications

References 88 publications

Axisymmetric Stokes flow due to a point-force singularity acting between two coaxially positioned rigid no-slip disks

Axisymmetric Stokes flow due to a point-force singularity acting between two coaxially positioned rigid no-slip disks

Erythrocyte-erythrocyte aggregation dynamics under shear flow

Mathematical modeling of chemotaxis guided amoeboid cell swimming

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