Amoebic liver abscess production by Entamoeba dispar

Dolabella, Silvio Santana; Serrano-Luna, Jesús; Navarro-Garcı́a, Fernando; Cerritos, René; Ximénez, Cecilia; Galván-Moroyoqui, José Manuel; Silva, Edward F.; Tsutsumi, Vı́ctor; Shibayama, Mineko

doi:10.1016/s1665-2681(19)31494-2

Cited by 40 publications

(28 citation statements)

References 31 publications

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“…For instance, Espinosa-Cantellano et al (Espinosa-Cantellano et al 2007) who infected hamsters with E. dispar via intra hepatic route found that it formed a focal inflammatory cell to infiltrate with no granuloma which might be the result from the incapability of E. dispar to establish experimental lesion because it is considered to be a commensal parasite. Another study (Dolabella et al 2012) reported the establishment of amoebic liver abscess by E. dispar.…”

Section: Histological Studymentioning

confidence: 99%

Histopathological study of invasive and non-invasive Entamoeba spp. in experimental rats

2019

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Background: The genus Entamoeba has many species that are invasive or non-invasive (E. histolytica, E. dispar, and E. moshkovskii).The invasive E. histolytica is the main pathogenic amoeba in human. Amoebiasis involves several stages starting with the adherence of the parasite to the intestinal epithelium, followed by degradation, tissue invasion, and distribution to other organs. Results: The current study investigates the pathological changes of Entamoeba spp. infection in both rectum and cecum of experimental rats. The results showed the histological changes at the 7th, 14th, and 28th day post-infection for the three species. E. histolytica and E. moshkovskii infection showed less pathological changes compared to E. histolytica. These changes include the attachment of the trophozoites to the mucosal layer, significant surface epithelial changes such as dissociation and degeneration in the mucosal layer, and ulceration of the apical surface. Inflammatory cells infiltrate the varied regions, extending into the deep mucosa causing mild architectural alterations. These are features of amoebiasis. Conclusion: The pathological changes reported in E. dispar and E. moshkovskii were less severe than E. histolytica.

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Section: Histological Studymentioning

confidence: 99%

Histopathological study of invasive and non-invasive Entamoeba spp. in experimental rats

2019

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“…Although E dispar is considered a harmless commensal organism, there are a few reports that suggest that E dispar may be capable of causing intestinal and extraintestinal diseases in humans and experimental animals. 15 Ali ENTAMOEBA MOSHKOVSKII E moshkovskii, which was mainly considered to be a free-living environmental ameba, is indistinguishable in both its cyst and trophozoite forms from E histolytica and E dispar. It was first discovered by Tshalaia 16 in 1941 in Moscow sewage.…”

Section: Entamoeba Disparmentioning

confidence: 99%

Intestinal Amebae

Ali¹

2015

Clinics in Laboratory Medicine

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Among the Entamoeba species that infect humans, Entamoeba histolytica causes diseases, Entamoeba dispar is a harmless commensal, Entamoeba moshkovskii seems to be a pathogen, and the pathogenicity of Entamoeba bangladeshi remains to be investigated. Species-specific detection needed for treatment decisions and for understanding the epidemiology and pathogenicity of these amebae. Antigen-based detection methods are needed for E dispar, E moshkovskii, and E bangladeshi; and molecular diagnostic test capable of detecting E histolytica, E dispar, E moshkovskii, and E bangladeshi simultaneously in clinical samples. Next-generation sequencing of DNA from stool is needed to identify novel species of Entamoeba.

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“…Studies of isoenzymatic patterns, antigenicity, and genetics have led the WHO to declare that E. histolytica and E. dispar should be classified as distinct species based on genetic differences in multiple genes [133, 219]. Recently, E. dispar was reported to present pathogenic behavior depending on the strain and culture conditions [220]. E. histolytica equivalent genes for virulence have been detected in E. dispar .…”

Section: Entamoeba Histolytica Related Strainsmentioning

confidence: 99%

“…This amoeba, which was isolated from a patient who was symptomatic but not dysenteric, was able to induce liver necrosis in hamsters in an even more severe form than that produced by E. histolytica and exhibited high CP activity [220]. Thus, E. dispar could exhibit pathogenic behavior with the potential to have an invasive role, depending on the strain and host conditions.…”

Section: Entamoeba Histolytica Related Strainsmentioning

confidence: 99%

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Proteases fromEntamoebaspp. and Pathogenic Free-Living Amoebae as Virulence Factors

Serrano-Luna

Piña-Vázquez

Reyes-López

et al. 2013

Journal of Tropical Medicine

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The standard reference for pathogenic and nonpathogenic amoebae is the human parasite Entamoeba histolytica; a direct correlation between virulence and protease expression has been demonstrated for this amoeba. Traditionally, proteases are considered virulence factors, including those that produce cytopathic effects in the host or that have been implicated in manipulating the immune response. Here, we expand the scope to other amoebae, including less-pathogenic Entamoeba species and highly pathogenic free-living amoebae. In this paper, proteases that affect mucin, extracellular matrix, immune system components, and diverse tissues and cells are included, based on studies in amoebic cultures and animal models. We also include proteases used by amoebae to degrade iron-containing proteins because iron scavenger capacity is currently considered a virulence factor for pathogens. In addition, proteases that have a role in adhesion and encystation, which are essential for establishing and transmitting infection, are discussed. The study of proteases and their specific inhibitors is relevant to the search for new therapeutic targets and to increase the power of drugs used to treat the diseases caused by these complex microorganisms.

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Amoebic liver abscess production by Entamoeba dispar

Cited by 40 publications

References 31 publications

Histopathological study of invasive and non-invasive Entamoeba spp. in experimental rats

Histopathological study of invasive and non-invasive Entamoeba spp. in experimental rats

Intestinal Amebae

Proteases fromEntamoebaspp. and Pathogenic Free-Living Amoebae as Virulence Factors

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