Amniotic Membrane Graft for the Treatment of Large Refractory Macular Hole

Abstract

This study was conducted to demonstrate refractory macular hole closure with human amniotic membrane graft and to evaluate type of closure Type I versus Type II.

Internal Plugging of a Traumatic Posterior Perforation Site Using Donor Sclera, Human Amniotic Membrane, and Fibrin Glue: A Novel Surgical Technique

“…PVR and retinal redetachment are common sequalae of intraocular bodies, especially in younger patients. 1 While it is possible that the introduction of the 3-layer plug in our case promoted PVR formation, human amniotic membrane has been used intraocularly in other instances, such as for macular hole repair, 10 retinal detachment, 11 optic disc pit maculopathy (ODPM), 12 and a choroidal patch. 13 Fibrin glue 14 and scleral patch graft 15,16 have also been used in ODPM.…”

Pretreated Lham Graft Covering for Retinal Detachment With Posterior Retinal Breaks Above Chorioretinal Atrophy in Pathologic Myopia

“…The human amniotic membrane plug was first used to promote the closure of recurrent MH 17,22 and was later used for treating myopic MHs with RD. 14,15 It was also used for repairing RD with PRBs located above PCRA in PM.…”

“…23 We also found that the LhAM plug might hinder the repair of the outer structure of the retina because it might stay between the retina and the retinal pigment epithelium for a long time. 17 In our previous study, we used autologous bloodassisted LhAM graft covering to treat eyes with MH in high myopia and showed that the MH closure rate was 83.3% postoperatively, and the surgical trauma was minimal. This was because the LhAM graft was placed right on the surface of the retina.…”

“…Once the graft was attached to the MH or posterior PRB, one drop of autologous blood was injected to cover the LhAM graft. 17 The PFCL-assisted pretreated LhAM graft covering. The LhAM graft was cut into a size slightly larger than the size of the MH or posterior PRB and then soaked in 0.125% ICG/50% hypertonic glucose solution for 15 to 20 minutes.…”

“…In our previous study, we showed that the autologous blood-assisted lyophilized human amniotic membrane (LhAM) graft covering was simple and effective in treating eyes with MHs in high myopia. 17 However, when we used this technique to treat RD eyes with MHs situated over MA or posterior PRBs situated over the area of PCRA, we found that the LhAM was difficult to be placed accurately on the MHs or posterior PRBs in the area of chorioretinal atrophy under gas, and complications such as graft dislocation often occurred postoperatively. Therefore, we modified this surgical technique by using PFCL-assisted pretreated LhAM graft covering to treat these eyes.…”