Amniotic membrane extract and eye drops: a review of literature and clinical application

Murri, Michael; Moshirfar, Majid; Birdsong, Orry C.; Ronquillo, Yasmyne C; Ding, Yanning; Hoopes, Phillip C

doi:10.2147/opth.s165553

Cited by 82 publications

(78 citation statements)

References 33 publications

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“…Furthermore, amniotic membrane is a rich source of biologically active factors and therefore promotes healing and acts as an effective material for wound dressing (Heerema‐McKenney ; Kaur & Bathla ; Murri et al. ; Sane et al. ; Olaya et al.…”

Section: Introductionmentioning

confidence: 99%

A human Amniotic Membrane plug to manage high myopic macular hole associated with retinal detachment

Caporossi

Angelis

Pacini

et al. 2019

Acta Ophthalmologica

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Objective To assess the efficacy of the human amniotic membrane (hAM) to treat (HMMH) associated with retinal detachment (RD). Material and Methods Ten eyes of 10 patients with recurrent HMMH and RD, who had already undergone one or more pars plana vitrectomy (PPV), underwent a PPV with an hAM plug implanted in the macular hole. The initial five patients enrolled were tamponaded with (SO) while the subsequent five patients with 10% octafluoropropane (C3F8). Silicon oil was removed in all five patients 2 months later. No statistical differences were reported between the two groups. Results Final retinal reattachment was achieved in all the patients. BCVA improved from 1.73 logMAR to 0.94 logMAR after 6 months. No adverse events were registered during follow‐up. Conclusion An hAM plug is an efficient substrate to manage HMMH associated with RD resulting in encouraging visual acuity recovery.

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Section: Introductionmentioning

confidence: 99%

A human Amniotic Membrane plug to manage high myopic macular hole associated with retinal detachment

Caporossi

Angelis

Pacini

et al. 2019

Acta Ophthalmologica

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“…(Alcaraz et al, 2015). The biomolecules and growth factors available in AM extract, including HGF, bFGF, EGF, and TGFß can induce limbal stem cells and promote corneal wound healing (Murri et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Vascular tissue engineering: Fabrication and characterization of acetylsalicylic acid‐loaded electrospun scaffolds coated with amniotic membrane lysate

Aslani

Kabiri

Kehtari

et al. 2019

Journal Cellular Physiology

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As the incidence of small‐diameter vascular graft (SDVG) occlusion is considerably high, a great amount of research is focused on constructing a more biocompatible graft. The absence of a biocompatible surface in the lumen of the engineered grafts that can support confluent lining with endothelial cells (ECs) can cause thrombosis and graft failure. Blood clot formation is mainly because of the lack of an integrated endothelium. The most effective approach to combat this problem would be using natural extracellular matrix constituents as a mimic of endothelial basement membrane along with applying anticoagulant agents to provide local antithrombotic effects. In this study, we fabricated aligned and random electrospun poly‐L‐lactic acid (PLLA) scaffolds containing acetylsalicylic acid (ASA) as the anticoagulation agent and surface coated them with amniotic membrane (AM) lysate. Vascular scaffolds were structurally and mechanically characterized and assessed for cyto‐ and hemocompatibility and their ability to support endothelial differentiation was examined. All the scaffolds showed appropriate tensile strength as expected for vascular grafts. Lack of cytotoxicity, cellular attachment, growth, and infiltration were proved using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay and scanning electron microscopy. The blood compatibilities of different scaffolds examined by in vitro hemolysis and blood coagulation assays elucidated the excellent hemocompatibility of our novel AM‐coated ASA‐loaded nanofibers. Drug‐loaded scaffolds showed a sustained release profile of ASA in 7 days. AM‐coated electrospun PLLA fibers showed enhanced cytocompatibility for human umbilical vein ECs, making a confluent endothelial‐like lining. In addition, AM lysate‐coated ASA‐PLLA‐aligned scaffold proved to support endothelial differentiation of Wharton's jelly‐derived mesenchymal stem cells. Our results together indicated that AM lysate‐coated ASA releasing scaffolds have promising potentials for development of a biocompatible SDVG.

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“…Their effectiveness was confirmed both in experimental studies and clinical trials. Finally, some commercial amnion‐derived products have been developed for ophthalmic use, for example, Amniotic Cytokine Extract (ACE), Regener‐Eyes, Optiserum and PDA‐AF …”

Section: Placental Tissues As Materials For Use In Medicinementioning

confidence: 99%

“…56 It is worth mentioning that the use of amniotic membrane in ophthalmic treatment is common and has been practiced for many years. 57,58 It has been shown that amnion effectively prevents the occurrence of inflammation and scarring as well as promotes healing in patients suffering from various ocular surface diseases. 7,[59][60][61] Amniotic membrane is commonly used with very good clinical effects in eye ulcerations, eye burns or corneal epithelial defects.…”

Section: Classical Applications Of Placental Tissues In Wound Healingmentioning

confidence: 99%

“…Finally, some commercial amnion-derived products have been developed for ophthalmic use, for example, Amniotic Cytokine Extract (ACE), Regener-Eyes, Optiserum and PDA-AF. 58,[68][69][70][71][72][73] Amnion transplants are also administrated (among others) on cut skin wounds, post-excision wounds, bullous skin diseases, pressure ulcers, wounds arising near or around the nervous tissue, on damages to the mouth and eye surface.…”

Section: Classical Applications Of Placental Tissues In Wound Healingmentioning

confidence: 99%

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Preparation of placental tissue transplants and their application in skin wound healing and chosen skin bullous diseases ‐ Stevens‐Johnson syndrome and toxic epidermal necrolysis treatment

Klama-Baryła¹,

Rojczyk

Kitala³

et al. 2020

International Wound Journal

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Unique properties of amniotic membrane make it a promising source for tissue engineering and a clinically useful alternative for patients suffering from chronic wounds including, for example, ulcers, burns, ocular surface damages and wounds occurring in the course of bullous diseases like stevens‐johnson syndrome and toxic epidermal necrolysis. Its use has many advantages over standard wound care, as it contains pluripotent cells, nutrients, anti‐fibrotic and anti‐inflammatory cytokines, growth factors and extracellular matrix (ECM) proteins. Placental tissues can be prepared as a medical component, an advanced therapy medicinal product or a tissue graft. In addition to basic preparation procedures such as washing, rinsing, cutting, drying and sterilisation, there are many optional steps such as perforation, crosslinking and decellularisation. Finally, transplants should be properly stored—in cryopreserved or dehydrated form. In recent years, many studies including basic science and clinical trials have proven the potential to expand the use of amniotic membrane and amnion‐derived cells to the fields of orthopaedics, dentistry, surgery, urology, vascular tissue engineering and even oncology. In this review, we discuss the role of placental tissues in skin wound healing and in the treatment of various diseases, with particular emphasis on bullous diseases. We also describe some patented procedures for placental tissue grafts preparation.

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Amniotic membrane extract and eye drops: a review of literature and clinical application

Cited by 82 publications

References 33 publications

A human Amniotic Membrane plug to manage high myopic macular hole associated with retinal detachment

A human Amniotic Membrane plug to manage high myopic macular hole associated with retinal detachment

Vascular tissue engineering: Fabrication and characterization of acetylsalicylic acid‐loaded electrospun scaffolds coated with amniotic membrane lysate

Preparation of placental tissue transplants and their application in skin wound healing and chosen skin bullous diseases ‐ Stevens‐Johnson syndrome and toxic epidermal necrolysis treatment

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