Amniotic Membrane-Coated Polypropylene Mesh for the Repair of Incisional Hernia: An Experimental Study In a Rat Model of Abdominal Wall Defect

Soylu, Sinan; Yıldız, Çağlar; Bozkurt, Birkan; Karakuş, Savaş; Kurt, Begüm; Kurt, Atilla

doi:10.5812/ircmj.62788

Cited by 7 publications

(9 citation statements)

References 25 publications

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“…This process includes regular cell migration and involvement of endothelial cells for angiogenesis (There are various growth factors and cytokines released to maintain wound healing. After homeostasis is achieved, the wound will experience 4 phases of healing, namely the inflammatory phase, epithelialization phase, proliferation phase, and maturation phase, where in the proliferation phase, fibroblasts have a major role in tissue proliferation and collagen synthesis (the main protein structure of the body) 8 .…”

Section: Discussionmentioning

confidence: 99%

The Effect of Dried Amnion Membrane Application in the Expression of Platelet Derived Growth Factors in the Healing Process of Stomach Stab Wound (Study on New Zealand Rabbit)

2021

IJPHRD

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Background: Management of penetrating abdominal trauma, especially those affecting the stomach, keeps developing. Although the technology in the field of surgery is getting more advanced, the risk of complications due to leakage is still common. A lot of research is being done to improve the tissue healing process, including a variety of surgical techniques and material uses. The amniotic membrane is a material that is widely used to help stimulate the healing process. The amniotic membrane contains growth factors, one of which is platelet-derived growth factor (PDGF). PDGF is a major player in the wound healing process.Purpose: To investigate the differences in PDGF levels in gastric rupture repair with dry amniotic membrane as a biological dressing compared to primary repair of gastric rupture without using dry amniotic membrane.Method: This research was an experimental analytical study, using 42 samples of rabbits which were grouped into 2 groups, namely the control and treatment groups. Stab wound of 2 cm by 0.5 cm wide with a depth entire gastric wall in gastric corpus was done and repaired with 4-6 interrupted suture using 5/0 polypropylene monofilament. In the control group, the wound was only sutured and the treatment group, dry amniotic membrane was applicated before suturing. The expression of PDGF was examined from the suture tissue on day-7.Result: Intensity score was obtained in the treatment group with the highest score of 2 with a sample of 11 (52.4%) as well as in the control group as many as 13 (61.9%) samples who had a score of 2. The extension score was obtained in the treatment group with the highest score of 1 with a total sample size of 10 (47.6%) while the control group had the highest score with a score of 0.5 as much as 14 (66.7%). After obtaining the PDGF intensity and extension values, then these two values are multiplied to get the PDGF expression. From the results of the comparison test using the Mann Whitney test, it was found that the difference in PDGF expression was significant between the treatment group and the control group with p = 0.008 (p <0.05). Conclusion:Applying dry amniotic membrane to the wound on the stomach will increase the expression of PDGF in the wound area.

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Section: Discussionmentioning

confidence: 99%

The Effect of Dried Amnion Membrane Application in the Expression of Platelet Derived Growth Factors in the Healing Process of Stomach Stab Wound (Study on New Zealand Rabbit)

2021

IJPHRD

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“…The highest degrees of inflammation and adhesions were recorded in PP Group, followed by OMNT Group as reported by Hu et al (2020). However, the BAM group had the lowest inflammation with the absence giant cells accompanied by good neovascularization and collagen deposition indicating excellent implant integration (Rashid et al, 2018;Soylu et al, 2018) (Table 1, Figures 2-4).…”

Section: Group B (Pp+bam)mentioning

confidence: 99%

Role of Bovine Amniotic Membrane in Repair of Abdominal Muscle Defects in Dogs

Mourad¹,

Abdelaal²,

Ezzeldein³

et al. 2020

AAVS

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“…The effectiveness of AM-coated PP mesh in comparison with single PP mesh on the prevention of abdominal adhesions was assessed. Findings show less adhesion and inflammation, higher epithelialization, and wound healing improvement when the AM was applied ( Najibpour et al, 2016 ; Soylu et al, 2018 ). Rashid et al conducted a similar study in the rat model.…”

Section: Composites Based On Amniotic Membranementioning

confidence: 99%