Amniotic Membrane as a Living Surgical Dressing in Human Patients

Trelford, John D.; Hanson, Frederick W.; Anderson, D. Greg

doi:10.1159/000224837

Cited by 22 publications

(7 citation statements)

References 3 publications

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“…The fibrin matrix provides an ideal substratum for migration of phagocytes and ensures that all the bacteria are within reach of the phagocytes 40 . This antibacterial effect is possibly also achieved by enzymes such as lysozyme, produced by the amnion, which may be bactericidal 31,42 . It has been shown that amniotic membrane induces a downregulation of transforming growth factor‐β signaling, responsible for fibroblastic activation in wound healing 43 .…”

Section: Discussionmentioning

confidence: 99%

“…In fact, the use of whole human fetal membranes or amnion alone in surgery has primarily developed to aid the repair of surface epithelial defects in the skin, 20,21 eye, 22,23 abdominal wall, 24 and peritoneum 25,26 . Although the field of obstetrics and gynecology is more concerned with fetal membranes, the use of amnion has not been popular, being restricted to its use as a graft in forming an artificial vagina, 27–30 a barrier to prevent postoperative intra‐abdominal adhesion formation, 25 and as a biological dressing following radical vulvectomies and groin dissections 31 . The aim of the present pilot study was to evaluate the safety and efficacy of amnion graft as an adjunctive therapy following hysteroscopic adhesiolysis.…”

Section: Introductionmentioning

confidence: 99%

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Amnion graft following hysteroscopic lysis of intrauterine adhesions

Amer

Abd-El-Maeboud

2006

J of Obstet and Gynaecol

161

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Amnion graft following hysteroscopic lysis of intrauterine adhesions

Amer

Abd-El-Maeboud

2006

J of Obstet and Gynaecol

161

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“…This beneficial effect of wound healing and host phagocyte activity has also been demonstrated when Op-Site, a commercially available semipermeable dressing, is applied to open wounds.3 Many other workers have since used amnion dressings to aid wound healing and confirmed an increased rate of re-epithelialisation, a decrease in pain, and a reduced incidence of infection. [4][5][6] I have used amnion dressings for the treatment of partial thickness burns and deep pretibial lacerations. The main advantage of this treatment has been that the patient has remained fully mobile and an outpatient throughout the whole course of treatment.…”

Section: Anne Ludbrook David Parkinmentioning

confidence: 99%

Pretibial injuries: a common pitfall

Christian¹

1983

BMJ

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“…Human amniotic membrane is believed to be nonimmunogenic [13]. Antibodies or cell-mediated immune response to amniotic membrane have not been demonstrated, suggesting low antigenicity and hence the recipient will not reject it.…”

Section: Introductionmentioning

confidence: 99%

Vaginal Wall Repair – Using Amniotic Membrane Graft

Seifeldin¹

2015

OGIJ

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IntroductionThe surgical repair of vaginal wall prolapse continues to remain one of the most difficult challenges in female pelvic floor reconstruction. The recurrence rate after standard colporrhaphy [1] ranges from 40-60 %. This high recurrence rate creates the necessity for developing new surgical techniques and better longterm solutions.The majority of the anterior vaginal wall prolapse results from paravaginal defects 70% (lateral detachments from the ATFP) -mostly unilateral, on the right side, and at the level of the ischial spines; rather than midline defect. This new understanding of site specific vaginal defects has lead to changes in surgical techniques, to include, abdominal, laparoscopic, and vaginal repairs. Abdominal paravaginal repair requires a more invasive approach and a longer postoperative recovery, while laparoscopic approaches are technically more difficult and challenging. Repair of vaginal wall prolapse by the vaginal route is usually simpler, and easier.Surgeons have been investigating the use of synthetic and biological grafts in vaginal wall prolapse repairs. The use of an absorbable polyglactin 910 mesh (Vicryl) has shown little benefit in its use to correct vaginal wall prolapse (42%) [2] and the use of a synthetic permanent polypropylene mesh for vaginal repair shows a mesh erosion rate of 18% [3], de novo urgency rate of 20%, and dysparunia 22% postoperatively. The mesh erosion rate or infection rate increased four-fold when the mesh was introduced vaginally as compared to the abdominal route in pelvic floor reconstruction cases [4].Many pelvic surgeons, are now using biological grafts for vaginal prolapse surgery, such as cadaveric fascia lata [5,6], Research Article AbstractBackground: Standard colporraphy has been the main surgical procedure for vaginal wall prolapse for many years, with disappointing cure rates. Many investigators are now searching for alternative surgical techniques and materials to achieve better long term, postoperative results. Amniotic membrane is a natural human membrane tissue; when used as a vaginal graft, it will attract collagen, fibrinogen, and integrate with the local fascia providing a tough sheath, necessary for support and augmentation of the weak local fascia, to support the bladder, rectum, and vagina. It has been proven to demonstrate low antigenicity (incomplete HLA-A, B, C, and DR antigens), and hence will not be rejected by the recipient.

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Amniotic Membrane as a Living Surgical Dressing in Human Patients

Cited by 22 publications

References 3 publications

Amnion graft following hysteroscopic lysis of intrauterine adhesions

Amnion graft following hysteroscopic lysis of intrauterine adhesions

Pretibial injuries: a common pitfall

Vaginal Wall Repair – Using Amniotic Membrane Graft

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