Amniotic Fluid L-Type Fatty Acid-Binding Protein in Predicting Fetal Condition

Evaluation of amniotic fluid neutrophil gelatinase-associated lipocalin and L-type fatty acid-binding protein levels during pregnancy

“… [22] This study showed that the amniotic fluid L-FABP level was strongly associated with fetal blood flow abnormalities without being affected by other factors and was a useful predictor of the fetal condition, specifically fetal hypoxia, which is similar to the finding of a previous report. [5] Additionally, the L-FABP level was not associated with HDP, but it tended to be associated with PE, which is the more severe category of HDP, causing maternal hypoperfusion. [24] L-FABP is expressed in human placenta, [25] and we speculated that increased expression of L-FABP in placenta caused by maternal hypoperfusion due to PE might lead to an elevated amniotic fluid L-FABP level.…”

“…We previously reported novel amniotic fluid biomarkers: the amniotic fluid neutrophil gelatinase-associated lipocalin (NGAL) level as a useful predictive factor of fetal inflammatory response syndrome (FIRS) [4] and L-type fatty acid-binding protein (L-FABP) as a useful predictive factor of fetal hypoxia. [5] Urinary NGAL and L-FABP levels are useful in detecting acute kidney injury caused by septic shock. [6] NGAL levels correlate with inflammatory markers such as the white blood cell count and C-reactive protein level, whereas L-FABP levels correlate with organ hypoperfusion or oxidative stress.…”