Amniotic fluid insulin-like growth factor binding protein 3 concentration as early indicator of fetal growth restriction

Murisier-Petetin, Geraldine; Gremlich, Sandrine; Damnon, F.; Reymondin, D.; Hohlfeld, P.; Gerber, Stefan

doi:10.1016/j.ejogrb.2009.01.004

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…In all, 162 studies were excluded, the main reasons being the lack of data to construct 2 × 2 tables (43%) and not being a test accuracy study (25%). Fifty‐three studies including 39 974 women, evaluating a total of 37 novel biomarkers, met the inclusion criteria . Box lists novel biomarkers for predicting IUGR that were identified in this review.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies provided data on a disintegrin and metalloprotease (ADAM)‐12, four on placental protein 13 (PP‐13), three on pregnancy‐specific β‐1‐glycoprotein, two on hepatocyte growth factor, and one each on insulin‐like growth factor binding proteins 1 and 3, activin A, placental growth hormone and annexin A5 . ADAM‐12 and PP‐13 were assessed at <20 weeks of gestation in all included studies.…”

Section: Resultsmentioning

confidence: 99%

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Novel biomarkers for predicting intrauterine growth restriction: a systematic review and meta‐analysis

Conde-Agudelo

Papageorghiou

Kennedy

et al. 2013

BJOG

129

101

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Background Several biomarkers for predicting intrauterine growth restriction (IUGR) have been proposed in recent years. However, the predictive performance of these biomarkers has not been systematically evaluated.Objective To determine the predictive accuracy of novel biomarkers for IUGR in women with singleton gestations.Search strategy Electronic databases, reference list checking and conference proceedings.Selection criteria Observational studies that evaluated the accuracy of novel biomarkers proposed for predicting IUGR.Data collection and analysis Data were extracted on characteristics, quality and predictive accuracy from each study to construct 2 9 2 tables. Summary receiver operating characteristic curves, sensitivities, specificities and likelihood ratios (LRs) were generated.Main results A total of 53 studies, including 39 974 women and evaluating 37 novel biomarkers, fulfilled the inclusion criteria. Overall, the predictive accuracy of angiogenic factors for IUGR was minimal (median pooled positive and negative LRs of 1.7, range 1.0-19.8; and 0.8, range 0.0-1.0, respectively). Two small case-control studies reported high predictive values for placental growth factor and angiopoietin-2 only when IUGR was defined as birthweight centile with clinical or pathological evidence of fetal growth restriction. Biomarkers related to endothelial function/ oxidative stress, placental protein/hormone, and others such as serum levels of vitamin D, urinary albumin : creatinine ratio, thyroid function tests and metabolomic profile had low predictive accuracy.Conclusions None of the novel biomarkers evaluated in this review are sufficiently accurate to recommend their use as predictors of IUGR in routine clinical practice. However, the use of biomarkers in combination with biophysical parameters and maternal characteristics could be more useful and merits further research.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Novel biomarkers for predicting intrauterine growth restriction: a systematic review and meta‐analysis

Conde-Agudelo

Papageorghiou

Kennedy

et al. 2013

BJOG

129

101

View full text Add to dashboard Cite

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Changes in amniotic fluid and umbilical cord serum proteomic profiles of foetuses with intrauterine growth retardation

et al. 2011

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Foetal growth is a result of a complex net of processes, requiring coordination within the maternal, placental, and foetal compartments, the imbalance or lack of which may lead to intrauterine growth restriction (IUGR). IUGR is the major cause of perinatal morbidity and mortality, and is also related to enhanced morbidity and metabolic abnormalities later in life. In the present study, the protein profiles of umbilical cord serum (UCS) and amniotic fluid (AF) of ten IUGR and ten appropriate for gestational age newborns have been analysed by 2-DE, and nanoHPLC-Chip/MS technology. A total of 18 and 13 spots were found to be differentially expressed (p<0.01) in UCS and AF respectively. The unique differentially expressed proteins identified by MS/MS analysis were 14 in UCS, and 11 in AF samples. Protein gene ontology classification indicate that 21% of proteins are involved in inflammatory response, 20% in immune response, while a smaller proportion are related to transport, blood pressure, and coagulation. These results support the conclusion that the IUGR condition alters the expression of proteins involved in the coagulation process, immune mechanisms, blood pressure and iron and copper homeostasis control, offering a new insight into IUGR pathogenesis.

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The long non-coding RNA NEAT1 is increased in IUGR placentas, leading to potential new hypotheses of IUGR origin/development

et al. 2014

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Amniotic fluid insulin-like growth factor binding protein 3 concentration as early indicator of fetal growth restriction

Abstract: Rapport de synthèseLa concentration d'IGFBP-3 dans le liquide amniotique, un indicateur précoce de la croissance intra-utérine

Cited by 6 publications

References 35 publications

Novel biomarkers for predicting intrauterine growth restriction: a systematic review and meta‐analysis

Novel biomarkers for predicting intrauterine growth restriction: a systematic review and meta‐analysis

Changes in amniotic fluid and umbilical cord serum proteomic profiles of foetuses with intrauterine growth retardation

The long non-coding RNA NEAT1 is increased in IUGR placentas, leading to potential new hypotheses of IUGR origin/development

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