Amniotic Fluid Heat‐stable Alkaline Phosphatase in Normal Pregnancy and in Pre‐eclampsia

Roopnarinesingh, S; Morris, David; Matadial, L

doi:10.1111/j.1471-0528.1972.tb15743.x

Cited by 11 publications

(2 citation statements)

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“…This suggests that the enzyme is released from the trophoblast and major proportion of it enters the maternal blood. [16,25] Thus, its increased level in maternal serum might be due to increased PALP. In present study it was observed that serum alkaline phosphatase levels were significantly high in preeclamptic cases as compared to normotensive controls.…”

Section: Discussionmentioning

confidence: 99%

Histochemistry of placental alkaline phosphatase in preeclampsia

Shevade

Arole

Paranjape

et al. 2016

Int J of Biomed & Adv Res

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Objectives: Placental alkaline phosphatase (PALP) is synthesized in placenta and increases with gestational age. Alkaline phosphatase supports pregnancy and could play an essential role in nutrient supply and growth of the fetus. Preeclampsia is a systemic disorder which affects 5 to 7 percent of women worldwide and is a major cause for maternal and neonatal morbidity and mortality. As it has a major role in fetal growth, nutrition and defense mechanism study of alkaline phosphatase enzymatic activity becomes essential. Methods: 50 normal and 50 preeclamptic placentae were collected immediately after delivery from Department of Obstetrics and Gynecology. Placentae were obtained from known preeclamptic consenting cases who had no history of hypertension before pregnancy or during first 20 weeks of gestation, who had consistently recorded systolic and diastolic blood pressure of 140 / 90 mm of Hg or above and proteinuria ≥ 300mg / 24 hrs. Alkaline phosphatase activity was demonstrated by using modified Gomori's method. Results: Intensity of PALP localization was stronger in preeclamptic placentae as compared to normotensive placentae. Conclusion: Placental ischemia is evident in preeclampsia. Uteroplacental insufficiency leads to increased syncytial damage in preeclamptic placentae which may lead to abnormally high PALP activity and consequent increase in serum alkaline phosphatase.

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Section: Discussionmentioning

confidence: 99%

Histochemistry of placental alkaline phosphatase in preeclampsia

Shevade

Arole

Paranjape

et al. 2016

Int J of Biomed & Adv Res

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“…The enzyme@) possibly enter the amniotic fluid from surrounding tissues (Geyer, 1970;Sutcliffe, 1975). Meconium stained amniotic fluid contains excessive amounts of ALP activity (Geyer and Schneider, 1970) and slightly elevated ALP levels have been found in pregnancies complicated by pre-eclampsia (Roopnarinesingh et al, 1972).…”

Section: Introductionmentioning

confidence: 99%

Alkaline phosphatase activity in amniotic fluid in pregnancies with fetal disorders

et al. 1983

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Alkaline phosphatase (ALP) activity was determined in 255 amniotic fluid samples collected by amniocentesis between 15 and 39 weeks of gestation. The samples were originally used for chromosomal analysis and/or alpha-fetoprotein measurements. The mean ALP activity in early amniotic fluid from pregnancies with fetal trisomy 18 and 21 syndromes was half of that found in the controls. Highly elevated ALP activity (over 10 times the median level) was found in 14 samples. Two of these pregnancies had normal outcome. Three samples were from pregnancies with intrauterine fetal death. Fetal disorders, including abdominal wall defect (four cases), Meckel's syndrome (two), hydrops fetalis syndrome (two) and genital anomaly (one), were observed in nine cases. Moderately elevated ALP activity (over three times the median) was found in 10 cases, including five pregnancies with a preterm labour shortly after the sample collection. The results indicate that elevated ALP activity in the third trimester amniotic fluid is often associated with fetal disorders.

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