Amniotic Fluid Embolism in Sweden, 1951–1980

Högberg, Ulf; Joelsson, Ingemar

doi:10.1159/000298984

Cited by 45 publications

(28 citation statements)

References 19 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The survival rate was similar to that reported by Högberg and Joelsson [21], who determined a survival interval of 12 h. There was no correlation between the survival time and the extent of the AFE. Fatal AFE is most commonly associated with relatively small tears in the uterus, cervix or vagina which have not totally disrupted the wall [11].…”

Section: Discussionsupporting

confidence: 89%

Forensic aspects of post-mortem histological detection of amniotic fluid embolism

et al. 2009

View full text Add to dashboard Cite

Amniotic fluid embolism (AFE) continues to be one of the most feared and devastating complications of pregnancy. A reliable diagnosis can be made only upon histological examination. A detection of AFE every now and then has a relevant implication on medico-legal aspects of intrapartum or post-partum maternal death. However, there are only isolated reports in the literature concerning the detection interval of amniotic fluid elements after their transfer into the lungs. The objective of this study was to determine how long after the onset of clinical symptoms the elements of amniotic fluid may be detectable in the pulmonary circulation. An autopsy, as well as a histological and toxicological examination of 29 women, who died intrapartum or post-partum were performed. AFE was diagnosed in seven women (25%). The maximum survival time of the women with AFE and also the detection interval of AF in the pulmonary vasculature was 36 h. In the lungs of the women who did not die of AFE, amniotic fluid components were not found. Thus, there is no evidence for a physiologic occurrence of AFE. In women who die some days or even weeks after delivery as a consequence of a haemorrhagic shock following post-partum genital bleeding ensuing from uterine atony, AFE should be considered as a cause of a coagulopathy.

show abstract

Section: Discussionsupporting

confidence: 89%

Forensic aspects of post-mortem histological detection of amniotic fluid embolism

et al. 2009

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5][6] The reported incidence of amniotic fluid embolism varies widely with rates varying from 1.9 per 100,000 to 6.1 per 100,000 3,5,10,[32][33][34][35][36][37][38][39][40][41][42] The reported rate appears to be closely related to the data source; series based on detailed review of individual case records generally detect a much lower rate than those based on birth and death certificates or discharge databases. 7,40 In some series, 30-60% of cases originally submitted as amniotic fluid embolism were found, after careful case review by experts, to not meet accepted diagnostic criteria.…”

Section: Incidencementioning

confidence: 99%

“…[32][33][34][35][36][37][38][39][40][41] Advanced maternal age and parity, male fetus, medical induction of labor, cesarean delivery, instrumental delivery, cervical trauma, placenta previa and abruption, and ethnic minority status have been found to be both significantly associated with amniotic fluid embolism and not associated with amniotic fluid embolism in various studies. [32][33][34][35][36][37][38][39][40][41] For example, in an initial Canadian study, labor induction was determined to be a significant risk factor. 38 However, a subsequent publication of a large series of patients in the United States by the same research group contradicted the original finding.…”

Section: Risk Factorsmentioning

confidence: 99%

Amniotic Fluid Embolism

Clark

2014

Obstetrics &Amp; Gynecology

160

129

View full text Add to dashboard Cite

Amniotic fluid embolism remains one of the most devastating conditions in obstetric practice with an incidence of approximately 1 in 40,000 deliveries and a reported mortality rate ranging from 20% to 60%. The pathophysiology appears to involve an abnormal maternal response to fetal tissue exposure associated with breaches of the maternal-fetal physiologic barrier during parturition. This response and its subsequent injury appear to involve activation of proinflammatory mediators similar to that seen with the classic systemic inflammatory response syndrome. Progress in our understanding of this syndrome continues to be hampered by a lack of universally acknowledged diagnostic criteria, the clinical similarities of this condition to other types of acute critical maternal illness, and the presence of a broad spectrum of disease severity. Clinical series based on population or administrative databases that do not include individual chart review by individuals with expertise in critical care obstetrics are likely to both overestimate the incidence and underestimate the mortality of this condition by the inclusion of women who did not have amniotic fluid embolism. Data regarding the presence of risk factors for amniotic fluid embolism are inconsistent and contradictory; at present, no putative risk factor has been identified that would justify modification of standard obstetric practice to reduce the risk of this condition. Maternal treatment is primarily supportive, whereas prompt delivery of the mother who has sustained cardiopulmonary arrest is critical for improved newborn outcome.

show abstract

“…It has been reported that 70% of the cases occurred pre-partum (21)(22)(23)(24) . Clinically, it's characterized as hypotension, cardiac arrhythmia, cyanosis, dyspnea, altered mental status and bleeding.…”

Section: Conditions Leading To Disseminated Intravascular Coagulationmentioning

confidence: 99%

Disseminated Intravascular Coagulation in Obstetrics: Ethiopathogenesis and up to date Management Strategies

Şahin¹,

Eroğlu²,

Tetik³

et al. 2014

J Turk Soc Obstet Gynecol

View full text Add to dashboard Cite

show abstract

Amniotic Fluid Embolism in Sweden, 1951–1980

Cited by 45 publications

References 19 publications

Forensic aspects of post-mortem histological detection of amniotic fluid embolism

Forensic aspects of post-mortem histological detection of amniotic fluid embolism

Amniotic Fluid Embolism

Disseminated Intravascular Coagulation in Obstetrics: Ethiopathogenesis and up to date Management Strategies

Contact Info

Product

Resources

About