Amniotic fluid chemokines and autism spectrum disorders: An exploratory study utilizing a Danish Historic Birth Cohort

Abdallah, Morsi; Larsen, Nanna; Grove, Jakob; Nørgaard‐Pedersen, Bent; Thorsen, Poul; Mortensen, Erik Lykke; Hougaard, David M.

doi:10.1016/j.bbi.2011.09.003

Cited by 116 publications

(76 citation statements)

References 37 publications

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“…These findings are intriguing in light of previous reports yielding support for the role of maternal infection during pregnancy [54][55][56][57] and the behavioral characteristics of infants later classified with ASDs. 58 …”

Section: E618mentioning

confidence: 39%

Autistic Traits in Children With and Without ADHD

et al. 2013

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WHAT'S KNOWN ON THIS SUBJECT: Studies examining the prevalence and associated features of autistic traits (ATs) in children with ADHD with exclusionary autism spectrum disorders suggest that children with ATs exhibit more severe social and interpersonal dysfunction reminiscent of the deficits in children with autism spectrum disorders. WHAT THIS STUDY ADDS:Our results suggest that ATs are overrepresented in ADHD children when compared with control subjects. They also suggest that the presence of ATs is associated with more severe psychopathology as well as more impaired interpersonal, school, family, and cognitive functioning. abstract OBJECTIVE: To assess the implications of autistic traits (ATs) in youth with attention-deficit/hyperactivity disorder (ADHD) without a diagnosis of autism.METHODS: Participants were youth with (n = 242) and without (n = 227) ADHD and controls without ADHD in whom a diagnosis of autism was exclusionary. Assessment included measures of psychiatric, psychosocial, educational, and cognitive functioning. ATs were operationalized by using the withdrawn + social + thought problems T scores from the Child Behavior Checklist. RESULTS:A positive AT profile was significantly overrepresented among ADHD children versus controls (18% vs 0.87%; P , .001). ADHD children with the AT profile were significantly more impaired than control subjects in psychopathology, interpersonal, school, family, and cognitive domains. CONCLUSIONS:A substantial minority of ADHD children manifests ATs, and those exhibiting ATs have greater severity of illness and dysfunction. Pediatrics 2013;132:e612-e622 AUTHORS:

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Section: E618mentioning

confidence: 39%

Autistic Traits in Children With and Without ADHD

et al. 2013

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“…204 Significantly altered adaptive cellular immune function in children with ASD may reflect defective immune activation, which may in turn be associated with ASD impairment. 203 Also, no significant differences have been reported for levels of certain chemokines in neonatal blood and amniotic fluid, 201,205 except in a subgroup with an ASD diagnosis based on the most recent diagnostic criteria. 201 …”

Section: Brain Inflammationmentioning

confidence: 99%

“…203 Also, no significant differences have been reported for levels of certain chemokines in neonatal blood and amniotic fluid, 201,205 except in a subgroup with an ASD diagnosis based on the most recent diagnostic criteria. 201 …”

Section: Brain Inflammationmentioning

confidence: 99%

“…Emerging evidence, mostly from case-control studies, has shown that increased proinflammatory cytokine production is found in the serum or cerebrospinal fluid of ASD children or the amniotic fluid of their mothers, [201][202][203] although a decreased neonatal level of cytokines has also been observed. 204 Significantly altered adaptive cellular immune function in children with ASD may reflect defective immune activation, which may in turn be associated with ASD impairment.…”

Section: Brain Inflammationmentioning

confidence: 99%

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Environmental factors associated with autism spectrum disorder: a scoping review for the years 2003–2013

Montigny

Ofner

et al. 2017

Health Promot Chronic Dis Prev Can

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Introduction: The number of children diagnosed with autism spectrum disorder (ASD) has been rapidly rising in the past decade. The etiology of this disorder, however, is largely unknown, although the environmental relative to the genetic contribution is substantial. We conducted a scoping review to comprehensively assess the current state of knowledge of the environmental factors present from preconception to early life associated with ASD, and to identify research gaps.

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“…More recent human studies found increased levels of IFN-γ, IL-4, and IL-5 in sera from mid-gestational mothers with a child that would later be diagnosed (Goines et al, 2011b) and elevated MCP-1 (Abdallah et al, 2012a), IL-4, TNF-α, and TNF-β levels in amniotic fluid (Abdallah et al, 2013). Most recently, studies have demonstrated that elevated mid-gestational levels of inflammatory cytokines and chemokines are more highly associated with the ASD subphentoype that presents with intellectual disability (ID), compared with ASD without ID, developmental delay (DD) without ASD, and typically developing controls (Jones et al, 2016).…”

Section: Cytokinesmentioning

confidence: 99%

The Role of the Immune System in Autism Spectrum Disorder

Meltzer

Water

2016

Neuropsychopharmacol

367

293

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Autism is a neurodevelopmental disorder characterized by deficits in communication and social skills as well as repetitive and stereotypical behaviors. While much effort has focused on the identification of genes associated with autism, research emerging within the past two decades suggests that immune dysfunction is a viable risk factor contributing to the neurodevelopmental deficits observed in autism spectrum disorders (ASD). Further, it is the heterogeneity within this disorder that has brought to light much of the current thinking regarding the subphenotypes within ASD and how the immune system is associated with these distinctions. This review will focus on the two main axes of immune involvement in ASD, namely dysfunction in the prenatal and postnatal periods. During gestation, prenatal insults including maternal infection and subsequent immunological activation may increase the risk of autism in the child. Similarly, the presence of maternally derived anti-brain autoantibodies found in~20% of mothers whose children are at risk for developing autism has defined an additional subphenotype of ASD. The postnatal environment, on the other hand, is characterized by related but distinct profiles of immune dysregulation, inflammation, and endogenous autoantibodies that all persist within the affected individual. Further definition of the role of immune dysregulation in ASD thus necessitates a deeper understanding of the interaction between both maternal and child immune systems, and the role they have in diagnosis and treatment.

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Amniotic fluid chemokines and autism spectrum disorders: An exploratory study utilizing a Danish Historic Birth Cohort

Cited by 116 publications

References 37 publications

Autistic Traits in Children With and Without ADHD

Autistic Traits in Children With and Without ADHD

Environmental factors associated with autism spectrum disorder: a scoping review for the years 2003–2013

The Role of the Immune System in Autism Spectrum Disorder

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