Amnesia and Pain Relief after Cardiopulmonary Resuscitation in a Cancer Pain Patient: A Case Report

Chon, Jin Young; Hahn, Yun Jin; Sung, Chih-Wei; Moon, Ho Sik

doi:10.3346/jkms.2012.27.6.707

Cited by 6 publications

(4 citation statements)

References 18 publications

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“…25 Additionally, there are 2 case reports of 3 patients with diverse chronic pain conditions that after an episode of significant memory loss experience dramatic decrease in their pain and in opiate use. 7,9 Given our results, the simplest explanation for these cases is that the memory loss is primarily due to hippocampal damage, which leads to disrupting persistent pain-related memory circuitry and diminished pain decrease even after substantial recovery from the amnesia. More systematic studies along these lines are urgently needed.…”

Section: Discussionmentioning

confidence: 80%

Role of adult hippocampal neurogenesis in persistent pain

Apkarian

Mutso

Centeno

et al. 2016

Pain

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The full role of adult hippocampal neurogenesis (AHN) remains to be determined, yet it is implicated in learning and emotional functions, and is disrupted in negative mood disorders. Recent evidence indicates that AHN is decreased in persistent pain consistent with the idea that chronic pain is a major stressor, associated with negative moods and abnormal memories. Yet, the role of AHN in development of persistent pain has remained unexplored. In this study, we test the influence of AHN in postinjury inflammatory and neuropathic persistent pain-like behaviors by manipulating neurogenesis: pharmacologically through intracerebroventricular infusion of the antimitotic AraC; ablation of AHN by x-irradiation; and using transgenic mice with increased or decreased AHN. Downregulating neurogenesis reversibly diminished or blocked persistent pain; oppositely, upregulating neurogenesis led to prolonged persistent pain. Moreover, we could dissociate negative mood from persistent pain. These results suggest that AHN-mediated hippocampal learning mechanisms are involved in the emergence of persistent pain.

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Section: Discussionmentioning

confidence: 80%

Role of adult hippocampal neurogenesis in persistent pain

Apkarian

Mutso

Centeno

et al. 2016

Pain

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“…For example, both mice and human subjects became hypersensitive to pain when tested in an environment previously associated with an aversive tonic pain experience ( 36 ). Clinical studies have reported that patients with chronic pain were suddenly relieved from chronic pain after amnesia (memory loss) ( 37 , 38 ). In itch studies, it has been demonstrated that merely thinking about itch can cause itch perception in patients with chronic itch, which rarely happens in healthy subjects ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

The Amygdala Network for Processing Itch in Human Brains

et al. 2020

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Itch is an unpleasant and aversive somatosensory experience. These negative emotions significantly affect mental health in patients with chronic itch; it is therefore important to understand the brain mechanism of negative emotions due to itch. The amygdala is a key hub of networks regulating negative emotions due to itch. However, the exact network involved in this process is unknown. This study used functional magnetic resonance imaging to investigate the amygdala network processing itch in 25 healthy subjects. Brain activity was measured during electrical itch stimuli using functional magnetic resonance imaging. During itch stimuli the amygdala exhibited increased functional connectivity with key brain regions of the serotonergic system responsible for negative emotions (the medial habenula and the median raphe nucleus) and with the memory system, which is responsible for consolidating emotional experiences (the parahippocampus and perirhinal cortex). The serotonergic and memory systems may become therapeutic targets to prevent or reduce diminished mental health commonly seen in chronic itch patients.

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“…These shared areas were found in the same group of healthy participants who underwent conditions of dyspnea (breathlessness) and pain, including the insular cortex, ACC, amygdala and medial thalamus 44 . The insular cortex and ACC have been found to be related to affective processing of pain 45 46 47 as well as attention and memory relevant to pain processing 48 49 50 51 52 53 . Memory plays an important role, particularly in chronic pain.…”

Section: Discussionmentioning

confidence: 99%

“…In animal models, localized micro-stimulation to the insular cortex during peripheral aversive stimulation leads to item-specific impairment of aversive memory reconsolidation, anterograde amnesia 52 . There are case reports that patients with chronic pain reported pain relief after sudden amnesia 48 54 . Taken together, these studies suggest that anterograde amnesia to aversive electrical stimulation could possibly be able to account for the observed BreEStim effects.…”

Section: Discussionmentioning

confidence: 99%

Pain modulation effect of breathing-controlled electrical stimulation (BreEStim) is not likely to be mediated by deep and fast voluntary breathing

2015

Sci Rep

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Voluntary breathing-controlled electrical stimulation (BreEStim), a novel non-invasive and non-pharmacological treatment protocol for neuropathic pain management, was reported to selectively reduce the affective component of pain possibly by increasing pain threshold. The underlying mechanisms involved in the analgesic effect of BreEStim were considered to result from combination of multiple internal pain coping mechanisms triggered during BreEStim. Findings from our recent studies have excluded possible roles of acupuncture and aversiveness and habituation of painful electrical stimulation in mediating the analgesia effect of BreEStim. To further investigate the possible role of voluntary breathing during BreEStim, the effectiveness of fast and deep voluntary breathing-only and BreEStim on experimentally induced pain was compared in healthy human subjects. Results showed no change in electrical pain threshold after Breathing-only, but a significant increase in electrical pain threshold after BreEStim. There was no statistically significant change in other thresholds after Breathing-only and BreEStim. The findings suggest that the analgesic effect of BreEStim is not likely attributed to fast and deep voluntary breathing. Possible mechanisms are discussed.

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Amnesia and Pain Relief after Cardiopulmonary Resuscitation in a Cancer Pain Patient: A Case Report

Cited by 6 publications

References 18 publications

Role of adult hippocampal neurogenesis in persistent pain

Role of adult hippocampal neurogenesis in persistent pain

The Amygdala Network for Processing Itch in Human Brains

Pain modulation effect of breathing-controlled electrical stimulation (BreEStim) is not likely to be mediated by deep and fast voluntary breathing

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