Ammonium salt modified mesoporous silica nanoparticles for dual intracellular-responsive gene delivery

Li, Yujie; Hei, Mingyang; Xu, Yufang; Qian, Xuhong; Zhu, Weiping

doi:10.1016/j.ijpharm.2016.07.029

Cited by 32 publications

(18 citation statements)

References 56 publications

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“…This same enlarged-pore strategy can also be used to develop stimuli-responsive gene transfection agents. For example, Li et al prepared MSNs with large conical pores functionalized with disulfide and amide bond-containing linkers with a positively-charged ammonium group at their end [ 95 ]. This assembly enables the loading of both plasmid DNA and siRNA, which would be released after cellular uptake as a consequence of the cleavage of the linkers, by either acidic endosomal pH or the reducing intracellular environment.…”

Section: Mesoporous Silica Nanoparticles For Gene Deliverymentioning

confidence: 99%

Mesoporous Silica Nanoparticles for Co-Delivery of Drugs and Nucleic Acids in Oncology: A Review

Paris

Vallet‐Regí

2020

Pharmaceutics

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Mesoporous silica nanoparticles have attracted much attention in recent years as drug and gene delivery systems for biomedical applications. Among their most beneficial features for biomedicine, we can highlight their biocompatibility and their outstanding textural properties, which provide a great loading capacity for many types of cargos. In the context of cancer nanomedicine, combination therapy and gene transfection/silencing have recently been highlighted as two of its most promising fields. In this review, we aim to provide an overview of the different small molecule drug-nucleic acid co-delivery combinations that have been developed using mesoporous silica nanoparticles as carriers. By carefully selecting the chemotherapeutic drug and nucleic acid cargos to be co-delivered by mesoporous silica nanoparticles, different therapeutic goals can be achieved by overcoming resistance mechanisms, combining different cytotoxic mechanisms, or providing an additional antiangiogenic effect. The examples here presented highlight the great promise of this type of strategies for the development of future therapeutics.

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Section: Mesoporous Silica Nanoparticles For Gene Deliverymentioning

confidence: 99%

Mesoporous Silica Nanoparticles for Co-Delivery of Drugs and Nucleic Acids in Oncology: A Review

Paris

Vallet‐Regí

2020

Pharmaceutics

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“…Moreover, Xu et al have prepared a pH and redox dual-responsive (MSN)-sulfur (S)-S- chitosan (CS) controlled release drug delivery system [ 254 ]. Besides, a redox- and pH-sensitive dual response MSN system has been developed by Li and colleagues using ammonium salt to seal the pores [ 255 ]. Yan et al have fabricated a pH/redox-triggered MSN nanosystem, for the codelivery of doxorubicin and paclitaxel in cancer cells [ 256 ].…”

Section: Effective Combination Of Active Targeting Therapy and Stimentioning

confidence: 99%

Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy

Barui

Cauda

2020

Pharmaceutics

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The presence of leaky vasculature and the lack of lymphatic drainage of small structures by the solid tumors formulate nanoparticles as promising delivery vehicles in cancer therapy. In particular, among various nanoparticles, the mesoporous silica nanoparticles (MSN) exhibit numerous outstanding features, including mechanical thermal and chemical stability, huge surface area and ordered porous interior to store different anti-cancer therapeutics with high loading capacity and tunable release mechanisms. Furthermore, one can easily decorate the surface of MSN by attaching ligands for active targeting specifically to the cancer region exploiting overexpressed receptors. The controlled release of drugs to the disease site without any leakage to healthy tissues can be achieved by employing environment responsive gatekeepers for the end-capping of MSN. To achieve precise cancer chemotherapy, the most desired delivery system should possess high loading efficiency, site-specificity and capacity of controlled release. In this review we will focus on multimodal decorations of MSN, which is the most demanding ongoing approach related to MSN application in cancer therapy. Herein, we will report about the recently tried efforts for multimodal modifications of MSN, exploiting both the active targeting and stimuli responsive behavior simultaneously, along with individual targeted delivery and stimuli responsive cancer therapy using MSN.

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“…The ammonium salt was connected via an amide and a disulfide linker to the MSN. Hence, the disulfide bond was reduced glutathione-dependently and the amide bond was degraded at low pH upon cellular uptake [ 72 ].…”

Section: Modifications To Control Cellular Uptake Drug Release Anmentioning

confidence: 99%

Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer

2017

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Even though cancer treatment has improved over the recent decades, still more specific and effective treatment concepts are mandatory. Surgical removal is not always possible, metastases are challenging and chemo- and radiotherapy can not only have severe side-effects but also resistances may occur. To cope with these challenges more efficient therapies with fewer side-effects are required. One promising approach is the use of drug delivery vehicles. Here, mesoporous silica nanoparticles (MSN) are discussed as biodegradable drug carrier to improve efficacy and reduce side-effects. MSN excellently fulfill the criteria for nanoparticulate carriers: their distinct structure allows high loading capacity and a plethora of surface modifications. MSN synthesis permits fine-tuning of particle and pore sizes. Moreover, drug release can be tailored through various gatekeeper systems which are for example pH-sensitive or redox-sensitive. Furthermore, MSN can either enter tumors passively by the enhanced permeability and retention effect or can be actively targeted by various ligands. PEGylation prolongs circulation time and availability. A huge advantage of MSN is their explicitly low toxic profile in vivo. Yet, clinical translation remains challenging. Overall, mesoporous silica nanoparticles are a promising tool for innovative, more efficient and safer cancer therapies.

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Ammonium salt modified mesoporous silica nanoparticles for dual intracellular-responsive gene delivery

Cited by 32 publications

References 56 publications

Mesoporous Silica Nanoparticles for Co-Delivery of Drugs and Nucleic Acids in Oncology: A Review

Mesoporous Silica Nanoparticles for Co-Delivery of Drugs and Nucleic Acids in Oncology: A Review

Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy

Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer

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