Ammonium derivatives of chromenones and quinolinones as lead antimicrobial agents

Gupta, Shilpi; Singh, Seema; Kathuria, Abha; Kumar, Manish; Sharma, Sweta; Kumar, Ram; Parmar, Virinder S.; Singh, Bharat; Gupta, Anjali; Eycken, Erik V. Van der; Sharma, Gainda L.; Sharma, Sunil K.

doi:10.1007/s12039-011-0147-7

Cited by 33 publications

(51 citation statements)

References 36 publications

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“…They are present at high levels in cinnamon and many fruits and vegetables (Krieger et al, 2013;Ribeiro da Silva et al, 2014). Different derivatives of these compounds possess a wide range of biological activities (Venugopala et al, 2013) such as antioxidant (Morabito et al, 2010;Natella et al, 2010;Pedersen et al, 2007), anti-inflammatory (Togna et al, 2014), antimicrobial (Gupta et al, 2012), and in vitro (Macakova et al, 2012) and in vivo platelet anti-aggregation effects .…”

Section: Introductionmentioning

confidence: 99%

Structure–activity relationship studies of 4-methylcoumarin derivatives as anticancer agents

Miri

Nejati

Saso

et al. 2015

Pharmaceutical Biology

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Materials and methods:We synthesized 27 coumarin derivatives (mostly having 4-methyl moiety) and examined their cytotoxic effect on three human cancer cell lines, K562 (chronic myelogenous leukemia), LS180 (colon adenocarcinoma), and MCF-7 (breast adenocarcinoma) by MTT reduction assay. Screened compounds included 7-hydroxy-4-methylcoumarins (7-HMCs), 7-acetoxy-4-methylcoumarins (7-AMCs), and different dihydroxy-4-methylcoumarin (DHMC) and diacetoxy-4-methylcoumarin (DAMC) derivatives. Some compounds with methoxy, amine, and bromine substitutions were also examined.Results: 7,8-DHMCs bearing alkyl groups at C3 position were the most effective subgroup, and of which, the most potent is compound 11, with an n-decyl chain at C3, which had IC 50 values of 42.4, 25.2, and 25.1 mM against K562, LS180, and MCF-7 cells, respectively. The second most active subgroup was 7,8-DAMCs containing ethoxycarbonylmethyl and ethoxycarbonylethyl moieties at C3 position. Compound 27 (6-bromo-4-bromomethyl-7-hydroxycoumarin), the only derivative containing bromine also showed reasonable cytotoxic activities (IC 50 range: 32.7-45.8 mM). Discussion and conclusion: This structure-activity relationship (SAR) study of 4-methylcoumarins shows that further investigation of these derivatives may lead to the discovery of novel anticancer agents.

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Section: Introductionmentioning

confidence: 99%

Structure–activity relationship studies of 4-methylcoumarin derivatives as anticancer agents

Miri

Nejati

Saso

et al. 2015

Pharmaceutical Biology

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“…One-dimensional nanofibers made of intrinsically conducting polymers (ICPs) have received much attention because of their applications in electronic devices such as chemical and biological sensors [3][4][5][6][7], transistors [8], Schottky diodes [9], solar cells [10] and new catalytic systems [11]. Recently, nanofibers and nanowires of poly(3-buthylthiophene) (P3BT) have been prepared by template electrochemical synthesis [12], whisker method [13], and using an electrospinning technique [14].…”

Section: Introductionmentioning

confidence: 99%

Comparison between inorganic geomimetic chrysotile and multiwalled carbon nanotubes in the preparation of one-dimensional conducting polymer nanocomposites

et al. 2015

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The aim of this study was to examine the role of the nanofillers spatial arrangement in the electrical properties of hybrid organic-inorganic fibers. In this paper, we have presented experimental results for preparation of fibers with a nanometric diameter based on a polyaniline/poly(ethylene oxide) doped blend and geomimetic chrysotile nanotubes. The nanostructured material was prepared using electrospinning techniques. Electrospun fibers made by pristine polymers and by the same blend loaded with carbon nanotubes were used as reference materials to compare the structural, and electrical properties of the novel organic-inorganic material. Generally, electrical properties were improved by the addition of materials that have high conductivity. Electrospun fibers filled with a traditional insulator like chrysotile have shown higher electrical conductivity than the pristine materials. In order to fully understand how structural variations impact upon the electrical conductivity the materials were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy (RS), differential scanning calorimetry (DSC) and four-point probe method. The results suggest that the occurred electrical conductivity gain could be attributed to parallel orientation of the chrysotile nanotubes and higher crystallinity induced by the one-dimensional nanostructured filler materials. The obtained results bring us one step closer to using intrinsically conducting polymers (ICPs) in the creation of functionalized polymeric nanocomposites for nanotechnology.

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“…Many literature reports are available on the application of CdS nanoparticles in the detection of visible radiation, enhancing efficiency of solar cells and a number of biological applications 3 . Due to high stability, excellent physical, chemical and structural properties, availability, ease of preparation and handling, CdS nanomaterials can be exploited in various fields of life.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Cadmium Sulphide Nanoparticles Using Annona Muricata Leaf Extract as Reducing/Capping Agent

2016

Chem Sci Trans

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Cadmium sulphide nanoparticles (CdS) have a great role in chemical research, biotechnology and medicine. The present study mainly involves development of an efficient and environmental friendly method of synthesis of cadmium sulphide nanoparticles by chemical precipitation method using green materials. Annona muricata leaf extract was used as a capping/reducing agent for the preparation of CdS nanoparticles. TEM, XRD, SEM with EDS and UVVis spectroscopy were used to study the morphology, distribution, crystallinity and size of the particle. Biological activity was studied using the bacterial strain staphylococcus aureus and aspergillus niger.

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Ammonium derivatives of chromenones and quinolinones as lead antimicrobial agents

Cited by 33 publications

References 36 publications

Structure–activity relationship studies of 4-methylcoumarin derivatives as anticancer agents

Structure–activity relationship studies of 4-methylcoumarin derivatives as anticancer agents

Comparison between inorganic geomimetic chrysotile and multiwalled carbon nanotubes in the preparation of one-dimensional conducting polymer nanocomposites

Synthesis and Characterization of Cadmium Sulphide Nanoparticles Using Annona Muricata Leaf Extract as Reducing/Capping Agent

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