Ammonia

Acceptorless dehydrogenative synthesis of primary amides from alcohols and ammonia

“…Ammonia is the simplest, most abundant precursor for the industrial preparation of nitrogen-containing compounds, but its application in selective homogeneously catalyzed organic synthesis by metal complexes has been challenging, partly due to the formation of stable Werner-type ammine complexes. 1 In 2008, our group reported an atom- and step-economical synthesis of primary amines from alcohols and ammonia, catalyzed homogeneously by an acridine-based PNP-type ruthenium pincer complex. 2 a Since then, environmentally benign processes, which involve coupling of alcohols and ammonia, and generate no hazardous waste, have been developed to access amines, imines (including N-heterocycles) and nitriles.…”

Titanium-Catalyzed Cyano-Borrowing Reaction for the Direct Amination of Cyanohydrins with Ammonia

“…As an atom-economic nitrogen source in organic synthesis, ammonia is the simplest and useful molecule . Amination of alcohols with the partner of ammonia represents an important direct procedure to synthesis primary amines .…”

Acceptorless Dehydrogenative Coupling Using Ammonia: Direct Synthesis of N-Heteroaromatics from Diols Catalyzed by Ruthenium

“…1 It is used for the synthesis of a wide range of commercially useful products, including amines, amides, ureas, carbamates, isocyanates, amino acids, N-heteroaromatic, and heterocyclic compounds. 2 Of particular interest and in the context of sustainable chemistry, environmentally benign routes to the catalytic synthesis of amines from readily available alcohols using ammonia and generating no hazardous waste is of much current attraction. In 2008, we reported the direct homogeneous catalytic selective amination of primary alcohols to primary amines using ammonia, catalyzed by an acridine-based Ru pincer complex (eq 1).…”

“…Ammonia is the simplest, useful molecule employed as a nitrogen source in synthesis, with generally high atom economy . It is used for the synthesis of a wide range of commercially useful products, including amines, amides, ureas, carbamates, isocyanates, amino acids, N-heteroaromatic, and heterocyclic compounds . Of particular interest and in the context of sustainable chemistry, environmentally benign routes to the catalytic synthesis of amines from readily available alcohols using ammonia and generating no hazardous waste is of much current attraction.…”