Ammi Visnaga L., a Potential Medicinal Plant: A Review

Khalil, Noha; Bishr, Mokhtar; desouky, samar; Salama, Osama

doi:10.3390/molecules25020301

Cited by 80 publications

(64 citation statements)

References 69 publications

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“…Both its umbels and fruits are known for their virtues on the urinary, cardiovascular systems, and oral health. It reduces hyperbilirubinemia and uremia 9 . According to Khan and Phyllis 10,11 studies, this plant extract prevents irritation, spasms in the urinary tract, and it has a diuretic action.…”

Section: Introductionmentioning

confidence: 99%

Identification and antioxidant activity of Ammi visnaga L. polyphenols from the Middle Atlas in Morocco

Karkouri

Drioiche²,

Soro³

et al. 2020

Mediterr.J.Chem.,

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In this work, we are interested in both the study of the phenolic compounds and the evaluation of the antioxidant properties of the extracts of Ammi visnaga L. collected from the Middle Atlas in Morocco. Phytochemical screening was carried out to highlight the qualitative composition of the secondary metabolites contained in this plant. Also, the extraction of total polyphenols was carried out by maceration using hydromethanolic and hydroacetonic mixtures. Then, the fractionation of the crude extracts was conducted by liquid-liquid extraction using successively two organic solvents with different polarities: ethyl acetate and n-butanol. The polyphenols contents were spectrophotometrically estimated using the Folin-Ciocalteau method. It showed that the ethyl acetate fraction is more abundant in phenolic compounds than the other fractions. The qualitative analysis was performed by high-pressure liquid chromatography with U.V. and electrospray ionization coupled to mass spectrometry (HPLC/UV-ESI-MS), which confirmed the richness of this species in polyphenols and particularly in flavonoids, especially by the identification of kaempferol, rhamnetin, biochanin A, ammiol. These molecules belong to flavones, flavonols, and furochromones, which are also identified both in the form of genin and of heteroside. The antioxidant activity of the different fractions was evaluated by diphenyl-picryl-hydrazyl (DPPH●). The IC50 is equal to 12.87 μg / mL for the ethyl acetate fraction, against 8.8 μg / mL for ascorbic acid and 10.8 μg / mL for BHA which are used as reference compounds.

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Section: Introductionmentioning

confidence: 99%

Identification and antioxidant activity of Ammi visnaga L. polyphenols from the Middle Atlas in Morocco

Karkouri

Drioiche²,

Soro³

et al. 2020

Mediterr.J.Chem.,

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“…The first mechanism is mediated through the antioxidant's effect. 14 The second mechanism is through decreasing lipid levels such as cholesterol and triglycerides as reported in other studies. 15 Using rat model, we previously found that molecular defects in the brain white matter were beyond the events involved in the development of diabetes.…”

Section: Discussionmentioning

confidence: 83%

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2020

AOWMC

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Introduction: Prediabetes status is considered as an important feature in either controlling the development or progression of diabetes. It may pass unnoticed because the symptoms of diabetes are usually not well established. Study objectives: The main objectives of the present study were to explore the efficacy of using Ammi visnagain treating pre-diabetic cases and weight losing. Methods and subjects: A prospective study was conducted to investigate the impact of using Ammi visnaga treatment of pre-diabetes and weight control. The study included 5 patients with pre-diabetes (glucose level was 128±32mg/dl). The age of patients was 42±18.5years. The study included 3 males and 2 females. In general, patients were overweight according to body mass index level was 28±7.8kg/m 2. The patients used the aqueous extract of Ammi visnaga for two months (200 ml daily). Results: At the end of the experiment, the glucose level was significantly reduced (p<0.05) to the level of 88±12.5mg/dl. There was also a significant reduction in the level of BMI from 28±7.8kg/m 2 to 22±6.4kg/m2(p<0.05). Conclusion: The results of the present study showed that Ammi visnaga has the therapeutic potential to control the progression of complete episodes of diabetes by controlling the pre-diabetic status.

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“…Ammi visnaga L. is an important medicinally active plant which is incorporated in several pharmaceutical preparations used worldwide [ 2 ]. The main pharmacologically active compounds in this plant are the furanochromones; khellin and visnagin.…”

Section: Discussionmentioning

confidence: 99%

“…Ammi visnaga L. (Apiaceae) is a popular commercial medicinal plant indigenous to Egypt and widely cultivated in the Mediterranean region and Europe [ 1 ]. The plant is industrially important as it is employed worldwide in many pharmaceutical products; either its extract or isolated active constituents [ 2 ]. It is widely used for its antispasmodic properties [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Conventional Solvent Extraction vs. Supercritical Fluid Extraction of Khella (Ammi visnaga L.) Furanochromones and Their Cytotoxicity

Khalil

Bishr²,

El-Degwy³

et al. 2021

Molecules

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Background: Khella (Ammi visnaga Lam.) fruits (Apiaceae) are rich in furanochromones, mainly khellin and visnagin, and are thus incorporated in several pharmaceutical products used mainly for treatment of renal stones. Methods: The objective of this study was to compare the yield of khellin and visnagin obtained using different conventional solvents and supercritical fluid extraction (SCFE) with carbon dioxide (containing 5% methanol as co-solvent). Water, acetone and ethanol (30% and 95%) were selected as conventional solvents. Results: Highest extract yield was obtained from 30% ethanol (15.44%), while SCFE gave the lowest yield (4.50%). However, the percentage of furanochromones were highest in SCFE (30.1%), and lowest in boiling water extract (5.95%). HPLC analysis of conventional solvent extracts showed other coumarins that did not appear in supercritical fluid extraction chromatogram due to non-selectivity of solvent extraction. Ammi visnaga extracts as well as standard khellin and visnagin were tested for their cytotoxic activity using sulforhodamine B assay on breast cancer (MCF-7) and hepatocellular carcinoma (Hep G2) cell lines. Results revealed a strong cytotoxic activity (IC50 < 20 µg/mL) for the SCFE and standard compounds (khellin and visnagin) (IC50 ranging between 12.54 ± 0.57 and 17.53 ± 1.03 µg/mL). However, ethanol and acetone extracts had moderate cytotoxic activity (IC50 20–90 µg/mL) and aqueous extract had a weak activity (IC50 > 90 µg/mL). Conclusions: Thus, supercritical fluid extraction is an efficient, relatively safe, and cheap technique that yielded a more selective purified extract with better cytotoxic activity.

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Ammi Visnaga L., a Potential Medicinal Plant: A Review

Cited by 80 publications

References 69 publications

Identification and antioxidant activity of Ammi visnaga L. polyphenols from the Middle Atlas in Morocco

Identification and antioxidant activity of Ammi visnaga L. polyphenols from the Middle Atlas in Morocco

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Assessment of Conventional Solvent Extraction vs. Supercritical Fluid Extraction of Khella (Ammi visnaga L.) Furanochromones and Their Cytotoxicity

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