Amlodipine-induced hypersensitivity reaction mimicking CD30+ mycosis fungoides

Gochoco, Ashley; Jones, Eric T.; Soutendijk, Christine; Alpdoğan, Önder; Shi, Wenyin; Sahu, Joya

doi:10.1016/j.jdcr.2016.06.013

Cited by 5 publications

(6 citation statements)

References 12 publications

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“…39 Complicating differential diagnosis and delineation of these responses are reports of CD30+ histology in hypersensitivity-like responses. 103-108 Conversely, case, group, and epidemiologic studies of failing or failed orthopedic implants have not been associated with lymphocyte-associated cancers. This is true despite intense surveillance of orthopedic implants that have failed due to metal debris and have been associated with proliferating lymphocyte accumulations (ie, metal-on-metal bearing total hip implants).…”

Section: Hypersensitivitymentioning

confidence: 99%

The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants

Hallab

Samelko

Hammond³

2019

Aesthetic Surgery Journal

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Currently, there is a dearth of information regarding the degree of particle shedding from breast implants (BIs) and what are the general biological consequences of BI debris. Thus, it is unclear to what degree BI debris compromises the long-term biological performance of BIs. For orthopedic implants, it is well established that the severity of biological reactivity to implant debris governs long-term clinical performance. Orthopedic implant particulate debris is generally in the range of 0.01 to 100 μm in diameter. Implant debris-induced bioreactivity/inflammation is mostly a peri-implant phenomenon caused by local innate immune cells (eg, macrophages) that produce proinflammatory cytokines such as tumor necrosis factor-α, interleukin-1β, interleukin-6, and prostaglandin 2 (PGE2). In orthopedics, there have been few systemic concerns associated with polymeric implant debris (like silicone) other than documented dissemination to remote organs (eg, liver, spleen, etc.) with no known associated pathogenicity. This is not true of metal implant debris where normal (well-functioning) implants can induce systemic reactions such as delayed type hypersensitivity. Diagnostic analysis of orthopedic tissues has focused on innate (macrophage mediated) and adaptive (lymphocyte-mediated hypersensitivity) immune responses. Orthopedic implant debris-associated lymphocyte cancers have not been reported in over 40 years of orthopedic literature. Adaptive immune responses such as hypersensitivity reactions to orthopedic implant debris have been dominated by certain implant types that produce specific kinds of debris (eg, metal-on-metal total joint prostheses). Orthopedic hypersensitivity responses and atypical BI bioreactivity such as BI-associated anaplastic large cell lymphoma share crossover markers for diagnosis. Differentiating normal innate immune reactivity to particles from anaplastic large cell lymphoma reactions from delayed type hypersensitivity reactions to BI-associated implant debris remains unclear but vital to patients and surgeons.

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Section: Hypersensitivitymentioning

confidence: 99%

The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants

Hallab

Samelko

Hammond³

2019

Aesthetic Surgery Journal

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“…Epidermotropic lymphocytic infiltrates can be found in a group of diseases that should be considered in differential diagnosis, once referred as the “six L's”: leprosy, lues (syphilis), lupus, lymphocytic infiltration of Jessner‐Kanof, lymphocytoma cutis (pseudolymphoma) and lymphoma …”

Section: Summary Of Existing Data On Cd123 Immunohistochemistry In Thmentioning

confidence: 99%

Lupus erythematosus mimicking mycosis fungoides: CD123⁺ plasmacytoid dendritic cells as a useful diagnostic clue

et al. 2018

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“…CD30 expression on small‐ or medium‐sized lymphocytes, in contrast to expression on large anaplastic or blastic cells, favours a benign aetiology, such as in this case. Amlodipine has been reported in the literature to induce CD30‐positive pseudolymphomas . A review of previously reported cases (Table ) reveals that 4 out of 5 cases demonstrate CD30‐positive T cells histopathologically.…”

Section: Discussionmentioning

confidence: 99%

“…Amlodipine has been reported in the literature to induce CD30-positive pseudolymphomas. [2][3][4][5] A review of previously reported cases (Table 1) reveals that 4 out of 5 cases demonstrate CD30positive T cells histopathologically. However, there has only been one other case exhibiting granulomatous inflammation, but without CD30 testing.…”

Section: Cd30 + Granulomatous Pseudolymphoma E347mentioning

confidence: 98%

“…10 Monoclonal T-cell populations in the skin or peripheral blood seem to be a recurring feature of the few cases of amlodipine-induced pseudolymphomas (Table 1). [1][2][3] Although it is a concerning feature, it is imperative to note that a T-cell monoclonal population alone is not diagnostic of lymphoid neoplasms, as monoclonality has been demonstrated in a variety of benign or reactive conditions. It is likely that administration of amlodipine produced a peripheral T-cell clone.…”

Section: Cd30 + Granulomatous Pseudolymphoma E347mentioning

confidence: 99%

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An instructive case of amlodipine‐induced reversible granulomatous CD30⁺T‐cell pseudolymphoma

et al. 2020

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We report an unusual case of drug-associated granulomatous CD30 + T-cell pseudolymphoma secondary to amlodipine. A 55-year-old Chinese man presented with a 6-month eruption of disseminated erythematous dermal papulonodules and annular infiltrated plaques over his neck and limbs symmetrically. Histopathology revealed a perivascular and interstitial infiltrate of histiocytes, eosinophils and morphologically normal lymphocytes associated with CD30 expression. The eruption improved rapidly after discontinuation of amlodipine and did not recur.

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Amlodipine-induced hypersensitivity reaction mimicking CD30+ mycosis fungoides

Cited by 5 publications

References 12 publications

The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants

The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants

Lupus erythematosus mimicking mycosis fungoides: CD123⁺ plasmacytoid dendritic cells as a useful diagnostic clue

An instructive case of amlodipine‐induced reversible granulomatous CD30⁺T‐cell pseudolymphoma

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Amlodipine-induced hypersensitivity reaction mimicking CD30+ mycosis fungoides

Cited by 5 publications

References 12 publications

The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants

The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants

Lupus erythematosus mimicking mycosis fungoides: CD123+ plasmacytoid dendritic cells as a useful diagnostic clue

An instructive case of amlodipine‐induced reversible granulomatous CD30+T‐cell pseudolymphoma

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Lupus erythematosus mimicking mycosis fungoides: CD123⁺ plasmacytoid dendritic cells as a useful diagnostic clue

An instructive case of amlodipine‐induced reversible granulomatous CD30⁺T‐cell pseudolymphoma