Amitriptyline in the Treatment of Anorexia Nervosa

Anorexia nervosa treatment: A systematic review of randomized controlled trials

“…In another study, amitriptyline in doses up to 175 mg/ day in 25 youth (aged 11-17 years) led to no significant differences in eating, mood, or weight outcomes in comparison with placebo. 22 No patients dropped out in this trial.…”

“…We rated two medication trials as good 18,19 and six as fair [20][21][22][23][24][25] (Table 3). The medications studied included second-generation antidepressants, 18,20 tricyclic antidepressants, 21,22 hormones, 19,23,24 and nutritional supplements.…”

“…The medications studied included second-generation antidepressants, 18,20 tricyclic antidepressants, 21,22 hormones, 19,23,24 and nutritional supplements. 25 Medication trials were commonly conducted in the context of clinical management or during or following inpatient refeeding.…”

Pharmacologic treatment of anorexia nervosa: Where do we go from here?

“…Follow-up assessments at 1 and 4 years found no long-term impact on weight gain in patients taking clomipramine. In two trials, conducted separately by Biederman et al 10 and Halmi et al, 11 amitriptyline showed no benefit when contrasted with placebo. Patients assigned to amitriptyline in these trials showed neither increased weight gain nor a decreased concern with shape and weight.…”

Tratamento farmacológico de transtornos alimentares

“…O uso de amitriptilina (Biederman et al, 1985) e de ciproeptadina (Halmi et al, 1986) favoreceu o ganho de peso para pacientes com AN, enquanto a ação da fluoxetina mostrou resultados contraditórios (Gwirtsman et al, 1990;Attia et al, 1998).…”