Amitriptyline for clozapine‐induced nocturnal enuresis and sialorrhoea

Praharaj, Samir Kumar; Arora, Meenakshi

doi:10.1111/j.1365-2125.2006.02748.x

Cited by 44 publications

(42 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A great number of cases in the past have reported clozapineinduced (Frankenburg et al 1996;Praharaj and Arora 2007), risperidone-induced (Hergüner and Mukaddes 2007), and olanzapineinduced (Vernon et al 2000) nocturnal enuresis. The occurrence mechanism of antipsychotic-induced enuresis has not yet been fully presented (Fuller et al 1996).…”

Section: Discussionmentioning

confidence: 96%

Desmopressin Use in the Treatment of Aripiprazole-Induced Nocturnal Enuresis in a Child Diagnosed with Autistic Disorder

Karakurt

Süren

2015

Journal of Child and Adolescent Psychopharmacology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 96%

Desmopressin Use in the Treatment of Aripiprazole-Induced Nocturnal Enuresis in a Child Diagnosed with Autistic Disorder

Karakurt

Süren

2015

Journal of Child and Adolescent Psychopharmacology

View full text Add to dashboard Cite

“…4 Nocturnal enuresis, a serious form of incontinence, has also repeatedly been associated with clozapine usage. [5][6][7] Because of these studies, clinicians today are far more aware of these conditions than in the past.…”

mentioning

confidence: 97%

A 2-Year Prospective Follow-Up Study of Lower Urinary Tract Symptoms in Patients Treated With Clozapine

Jeong

Kim²,

Ahn³

et al. 2008

Journal of Clinical Psychopharmacology

View full text Add to dashboard Cite

Urinary incontinence and enuresis are well-known side effects of clozapine. However, clinical experience has shown that patients also suffer from diverse lower urinary tract symptoms (LUTS). The natural course of clozapine-related LUTS is unclear. Thus, a longitudinal follow-up study is needed. A total of 101 subjects who were taking clozapine initially participated. Their LUTS were evaluated using the International Prostate Symptom Score (IPSS), other questionnaires, and a medical records review. After 2 years, 87 of the original subjects could be contacted, and the status of their LUTS was re-evaluated. The average IPSS total was 7.4 +/- 5.9 at the initial evaluation. Although only 11 subjects (10.9%) reported actual incontinence, 42 subjects (41.6%) were found to have clinically significant LUTS (IPSS total score > or =8). No influencing factors could be found among the demographic and clinical variables. At the follow-up, the average IPSS total (7.9 +/- 6.0) and the percentage of subjects with clinically significant LUTS (43.7%) had both increased, although the change was not statistically significant. The prevalence of LUTS in clozapine-medicated patients was higher than in the general population of the same age. However, the prevalence of incontinence was only a quarter of that of LUTS. If clinicians focus only on incontinence, distress from LUTS will not receive appropriate attention. Furthermore, contrary to literature observations, clozapine-related LUTS did not remit easily but rather persisted even into the long-term maintenance phase. More concern should be directed at these troublesome and often neglected side effects.

show abstract

“…Amitriptyline has been used to be useful in clozapineinduced sialorrhea (14,15). The treatment of sialorrhea with amitriptyline suggested to be the result of its multiple mechanisms may be responsible.…”

Section: Case Presentationsmentioning

confidence: 99%

“…In the treatment of antipsychotics-induced sialorrhea is used α2-adrenergic receptor agonist or anticholinergic drugs (14). Amitriptyline is a tricyclic antidepressant, which blocks serotonin and norepinephrine transporters, exerts α2-adrenergic receptor antagonism, M4 muscarinic receptor agonism, and reduces laryngeal peristalsis (15).…”

Section: Case Presentationsmentioning

confidence: 99%