Amisulpride for the treatment of very‐late‐onset schizophrenia‐like psychosis

Abstract

Preliminary results indicate that amisulpride appears to be an efficacious and safe atypical antipsychotic for the treatment of very-late-onset schizophrenia-like psychosis.

Elderly patients with very late-onset schizophrenia-like psychosis and early-onset schizophrenia: Cross-sectional and retrospective clinical findings

“…Good response to atypical neuroleptics in VLOSLP is consistent with previous data [20,26,34,35]. Indeed few positive symptoms were actually endorsed in the current condition (follow-up) by the patients, with delusions being the most present in 50% of the VLOSLP and 69% of the EOS.…”

“…VLOSLP individuals, especially inpatients [35], responded well to atypical antipsychotics [20,35], and in particular to amisulpride [34].…”

“…Good response to antipsychotics [24,26,34,35], even better than in LOS [24] and elderly EOS patients [24,26], was often registered in VLOSLP patients. VLOSLP individuals, especially inpatients [35], responded well to atypical antipsychotics [20,35], and in particular to amisulpride [34].…”

Velocardiofacial syndrome - a syndrome with many faces

“…These patients with late-onset (older than 40) or very late-onset (older than 60) schizophrenia show similar characteristics to those with early-onset schizophrenia with regard to psychopathology, family history, cognitive deficits , nonspecific brain imaging abnormalities and treatment response.38 However, late-and very late-onset schizophrenia psychosis is more often associated with paranoid symptoms, less severe cognitive impairment and a need for lower dosages of antipsychotic medication. [39][40][41][42][43][44] These patients also tend to have higher levels of education and relatively more of them are married. [41][42][43][44][45] The proportion of patients with schizophrenia who present with lateonset schizophrenia has been estimated at 23%.…”

Very Late Onset Schizophrenia like Psychosis at Eighties: A Case Vignette and Comprehensive Literature Review

“…The diagnosis of very late-onset schizophrenia like psychosis has been proposed for patients who experience the onset of symptoms after the age of 60 years [1] and they present with some characteristics similar to those of early-onset schizophrenia in terms of psychopathology, non-specific brainimaging abnormalities, course of illness, and treatment response [2]. Importantly the emergence of psychotic symptoms for the first time in later life poses a diagnostic challenge for clinicians in assessment of elderly persons with mental illness as they are frequently confronted with issues relating to cognitive deficits, affective symptomatology, and physical illness [3].…”